NIH National Institute of Allergy and Infectious Disease

55 Active Projects

Title Investigator Start End
Fetal Zika virus infection: role of the human placenta Pereira
Novel Therapeutics for Treatment of River Blindness and Lymphatic Filariasis Sakanari
Identification of diagnostic and prognostic host biomarkers of Zika virus infection by transcriptome profiling Chiu
Characterization of a New Anti-HIV Immune Protein Levy
HIV Viral Reservoirs and Monocyte Activation in HIV-Associated Atherosclerosis Hsue
Generation of therapeutic antibodies for serotype F botulism (Continuation of A120963 from NIH G Pool to Subaccount) Marks
Mentoring Translational Researchers for Careers in Pediatric Global Health Feeney
Determinants of Functional Immune Defects in Treated HIV Infection and Aging Hunt
Interaction between Innate and Th2 Lymphocytes in Helminth Immunity Nussbaum
Host-Directed Strategies to Create Synergistic Antibacterial Therapies Cox
Microbial Pathogenesis and Host Defense Engel
Plugging Hair ARV Levels as Adherence Biomarkers into HIV Prevention Trials Gandhi
Evaluation of Novel Tuberculosis Screening Strategies for People living with HIV Yoon
Resistance of Malaria Parasites to Artemisinin-Based Therapies Rosenthal
Timing of ART and homeostasis of the persistent HIV reservoir in the adult McCune
Pharmacodynamics of Antimalarial Chemoprevention Rosenthal
Childhood Tuberculosis Infection Among School-Age Children in Rural Uganda Marquez
Regulation of Innate Immune Signaling by Lyn Kinase Lowell
Microfluidic PCR Method to Identify and Characterize HIV-Infected Single Cells Henrich
Ubiquitin and Psoriasis Ma
New approaches to study Pseudomonas-host interactions Engel
Gene circuits that control morphology in Histoplasma Sil
The impact of TB co-infection on the reservoir of persistent HIV in vivo McCune
Role of Host Cells in Invasive Listeriosis Bakardjiev
Epigenetic control of virulence in a fungal meningitis pathogen Madhani
Novel methods of pharmacologic monitoring for multidrug resistant tuberculosis treatment in the setting of HIV infection Metcalfe
Impact of Chemotherapy and Stem Cell Transplant on HIV-1 Reservoir Dynamics Henrich
Impact of CCR5 Blockade in HIV+ Kidney Transplant Recipients Stock
Cytoskeletal Regulation of T cell Motility and Synaptic Signaling Krummel
UZ-UCSF Clinical Trials Unit Chirenje
The transcriptional circuitry controlling biofilm development in Candida albicans Johnson
The cell and molecular mechanisms underlying CD28 costimulation Weiss
Humanized Mouse Models for HIV Therapeutics Development Stoddart
Novel serologic assays of P. falciparum exposure for improved surveillance in control and elimination. R01 resubmision Greenhouse
Effector and regulatory T cell responses and protection from clinical malaria Feeney
Improving the molecular diagnosis of drug resistant tuberculosis Kato-Maeda
Fine-tuning the Neutrophilic Response to Pneumonia Looney
Defining the unique properties of the distinct signaling machinery used by the TCR Weiss
Adapting to a changing environment: How surface contact induces virulence factor production in Pseudomonas aeruginosa Engel
Training in HIV Translational Research Havlir
Single-cell trancriptomic analysis of HIV infected CD4 cells in blood and lymphoid tissue using PCR activated cell sorting Abate
Elucidating the mechanism of progesterone-induced permissivity in the upper female reproductive tract Roan
Simplified Isoniazid Preventive Therapy (SPIRIT) Strategy to Reduce TB Burden Havlir
Regulatory Circuits and Virulence in Candida albicans Johnson
Hair Extensions;: Using Hair Levels to Interpret Adherence, Effectiveness and Pharmacokinetics with Real-World Oral PrEP, the Vaginal Ring, and Injectables Gandhi
Sputum Transcriptomic Expression Profiling in Study 31: Express 31 Nahid
Therapeutic vaccination and PD-1 blockade in treated HIV disease Deeks
Mentoring Multidisciplinary Patient-Oriented Research in Engagement in HIV Care Geng
The Immunologic Impact of In Utero Malaria Exposure and Prenatal Chemoprevention Prahl
Mentoring in Patient Oriented Research on Food Insecurity, HIV and Aging, Weiser K24 Weiser
Thymic medullary epithelial cell turnover and control of immune tolerance Anderson
Recent Advances in AIDS and HIV Research Volberding
UCSF-Gladstone Center for AIDS Research Volberding
Biology of Infectious Diseases Training Program Chambers
Program for Resistance, Immunology, Surveillance & Modeling of Malaria in Uganda (PRISM) Renewal Dorsey

261 Archived Projects

Title Investigator Start End
San Francisco STDs CRC Padian
Penicillin Interactive Proteins of Staphylococcus Aureus Chambers
Immunomodulation of Transplant Rejection by Anti-CD3 mAb Bluestone
Evaluation of Falcipain as an Antimalarial Drug Target Rosenthal
Population Genetics of the PO1 Locus of SIV and HIV-1 Delwart
Role of Notch 1 in Immunie Tolerance Bluestone
WIHS Treatment Exposure and Viral Rebound Study / AIDS Research Greenblatt
Treatment Intensification for Drug-Resistant HIV Deeks
Role of MmpL Transporters in M. Tuberculosis Virulence Cox
Rhinoviruses, Epithelial Cells, and Airway Function Boushey
Drug Resistant Malaria Clinical and Laboratory Studies Staedke
Biology of Infectious Diseases Training Program [I] Chambers
Predicting Resistance: Validating Mathematical Models Lietman
Adult AIDS Clinical Trials Unit (AACTU) Havlir
STD Risks and Latino Adolescents' Sexual Networks Padian
Role of Innate Immunity in Controlling HIV Infection Levy
UCSF AIDS Research Training Program Levy
T Regulatory Cells and T Cell Activation in HIV Disease Deeks
Recombinant Picornaviruses as AIDS Vaccines Andino-Pavlovsky
Microarray-Based Detection and Typing of Rhinoviruses Boushey
Innate NKT Cells in HIV Infection Nixon
Spontaneous Autoimmune Model of Peripheral Neuropathy Bluestone
Phase 1/2 Trial of Pharmacological HIV-1 Prevention Page
Population-Based Molecular Epidemiology of Tuberculosis Hopewell
Coming Together to Overcome HIV/AIDS in Zimbabwe and Zambia Padian
The Zimbabwe-San Francisco HIV Prevention Trials Unit Chipato
The Connie Wofsy Womens' HIV Study Greenblatt
Double-Stranded RNA Virus in Giardia Wang
Therapeutic Strategies for HIV Disease Havlir
Falcipain Cysteine Proteases of Malaria Parasites Rosenthal
Mechanisms of Bartonella Virulence in AIDS Patients Koehler
Immunologic and Virologic Features of Early HIV Infection Levy
An Intervention for Male STD Patients in India / HIV Related Lindan
Novel Anti-Malarials by Combinatorial Pharmacogenomics Derisi
Utility of Rapid Diagnostic Tests for Malaria Hopkins
A Chemical Map of T Cell Signaling Shokat
Role of Innate Immunity in Controlling HIV Infection Levy
CD4+ T Cell Receptors in Leishmaniasis Locksley
Host Protein Degradation by Schistosome Parasites McKerrow
Assessing Laboratory Correlates of Immune Protection McCune
Human Papillomavirus as a Risk Factor for HIV Infection Chin-Hong
Regulation of the Development of Tryanosoma brucei Wang
Anti-Gag Antibodies and Enhancement of Lentiviral Disease Progression McCune
Viral Tropism and Immune Control in HIV Nixon
Resistance of Malaria Parasites to Artemisinin-Based Combination Therapies Rosenthal
Regulation of ESX-1 secretion and its role in M. tuberculosis virulence Cox
Regulation of the Development of Trypanosoma brucei Wang
RNA Protein Interactions in Poliovirus Replication Andino-Pavlovsky
Immunomodulation of Transplant Rejection by Anti-CD3 mAb Bluestone
Clinical and Molecular Studies of Drug Resistant Malaria [I] Rosenthal
The Determinants of T Cell Activation in HIV Infection Hunt
Thymic Function in Adults With HIV-1 Disease McCune
Host Polymorphisms and Uncomplicated Malaria Parikh
Purine Metabolism in Trichomonas Vaginalis Wang
Targeting Cysteine Proteases--Antiparasitic Chemotherapy McKerrow
Training in HIV Translational Research Havlir
Role of Innate Immunity in Controlling HIV Infection Levy
An Endogenous Retroelement Vaccine against HIV-1 Nixon
Clinical Studies of Interactions Between HIV and Malaria Havlir
UZ-UCSF Clinical Trials Unit Chirenje
NK Cell Receptors and Their Ligands Lanier
HIV Effects on the Central Hematolymphoid System McCune
Oral Wash for Nucleic Acid Diagnosis and Prognosis of TB in HIV-Infected Ugandans Davis
NK and T Cell Costimulation by NKG2D/DAP10 Lanier
Mechanisms of Leukocyte Integrin Signaling Lowell
Innate Immune Response Genetics and T cell Activation in Treated HIV Infection Hunt
Immunological Detection and Control of Experimental Uncomplicated Malaria Kim
Protective immunity in HIV Highly Exposed but Uninfected Subjects Nixon
Innovative Methods for Measuring Antiretroviral Exposure Greenblatt
UZ-UCSF Collaborative Research Program Miller
HPV Epidemiology and Response to Screening (HEARTS) Riley
Spontaneous Autoimmune Model of Peripheral Neuropathy Bluestone
Virus Detection Using Microarrays and Characterization of a Novel Cardiovirus Chiu
Manipulation of Macrophage Responses by M. tuberculosis Cox
Oral Wash for Nucleic Acid Diagnosis and Prognosis of TB in HIV-Infected Ugandans Davis
Tissue-Based Small Animal Model for HIV Drug Discovery Stoddart
Cell Mediated Immunity in HIV-Infected Children Nixon
Role of Innate Immunity in Controlling HIV Infection Levy
HIV Effects on the Central Hematolymphoid System McCune
Dissecting the HLA Contribution to Rheumatoid Arthritis Criswell
Regulatory T Cell Influence on Infant and Adult Immune Responses to HIV Hartigan-O'Connor
Dissecting the HLA contribution to Rheumatoid Arthritis Criswell
UCSF-GIVI Center for AIDS Research (old) Volberding
Molecular Mechanisms of Plasmodium falciparum Adherence to the Human Placenta Fisher
Preventing the Establishment of Enfuvirtide-Resistance in the Latent Reservoir Deeks
Inflammation, T Cell Senescence, and Mortality in Treated HIV Infection Hunt
T Regulatory Cells in HIV Infection Nixon
Virologic and Host Factors Contributing to HIV Control in Elite Controllers Hatano
Secretion of Virulence Factors by Mycobacterium tuberculosis Cox
Innate Natural Killer T (NKT) Cells in HIV Infection Nixon
Assessing Antiretroviral Exposure in Diverse Populations Gandhi
Oxygen Sensors and P450 Monooxgenases in Mycobacterium tuberculosis Ortiz De Montellano
The Impact of Early Antiretroviral Therapy on HIV Persistence and Inflammation Deeks
Biology of Infectious Diseases Training Program [II] Chambers
Population-Based Molecular Epidemiology of Tuberculosis in San Francisco Hopewell
The Impact of Early Antiretroviral Therapy on HIV Persistence and Inflammation Deeks
UCSF-Gladstone Center for AIDS Research (CFAR) Volberding
Discovery of Oxaboroles as New Antimalarial Agents Rosenthal
RNAi as an Intercellular Antiviral Defense Mechanism Andino-Pavlovsky
Spontaneous Autoimmune Model of Peripheral Neuropathy Bluestone
Novel Mechanisms of Beta-Lactam Resistance in Staph aureus Chambers
The Connie Wofsy Women's HIV Study Greenblatt
The Impact of CD8 T Cells on Viral Control and Evolution in HIV-Infected Infants Feeney
Chemical Methods for Ferrous Iron Targeted Drug Delivery Renslo
13Th International Meeting of the Society for Natural Immunity April 20-24, 2012 Lanier
Protective Immunity in HIV Highly Exposed but Uninfected Subjects Nixon
Translation Regulation in Giardia lamblia Wang
HIV Status and Reproductive Aging Affect Liver Fibrosis in HIV/HCV Infected Women Peters
The Connie Wofsy Women's HIV Study Greenblatt
Oral Wash for Nucleic Acid Diagnosis and Prognosis of TB in HIV-infected Ugandans Davis
Initiation of Allergic Immunity by Parasites Locksley
Sputum M. tuberculosis DNA Kinetics during TB Treatment in Patients with HIV Everett
A Rapid Pan-Viral Microarray Diagnostic for Category A-C Biodefense Pathogens Chiu
Translational Studies of Plasmodium Falciparum Infection Dynamics Greenhouse
Development of Botulinum Neurotoxin Immunotherapy, Serotypes C, D, F, and G Marks
Reproductive Infectious Disease (RID) Fellowship Cohen
Immunological Detection and Control of Experimental Uncomplicated Malaria Kim
Resequencing Microarray for Rapid Detection and Antimicrobial Resistance Profiling Lynch
Age-Dependent Immune Responses to Hepatitis B: a Mouse Model of Human Disease Baron
HIV cure with CCR5 (-) human IPS hematopoietic stem cells Levy
Global Health Comparative Effectiveness: A Data Synthesis Method Applied to HIV Kahn
Human Endogenous Retroelements in HIV Immunopathogenesis Nixon
A Novel APOBEC-Based Vaccine Approach for HIV Nixon
Innate NKT Cells in HIV Infection Nixon
University of Zimbabwe-UCSF Clinical Trials Unit Chirenje
Cervical Maturity, Mucosal Immunity, and Chlamydia trachomatis Infections Hwang
Regulation of the Development of Trypanosoma brucei Wang
B Cells in Central Nervous System (CNS) Autoimmunity Zamvil
Human Immune System Layering and the Neonatal Response to Vaccines McCune
Genetic Diversity as a Determinant of Viral Pathogenesis and Attenuation Andino-Pavlovsky
Exploring the Role of Semen Amyloids in Promoting HIV Infection and Fertilization Roan
The Hair Trigger Study Greenblatt
UCSF HIV Clinical Trials Unit Havlir
2013 NIH Workshop on Protein Homeostasis and Viral Infection Andino-Pavlovsky
Lead Identification to Clinical Candidate Selection: Drugs for Chagas' Disease McKerrow
TB Guidline Observation and Adherence in Low Income Countries (TB GOAL) Cattamanchi
IDO-induced Tryptophan Catabolism and Mortality in Treated HIV-infected Africans Hunt
Early Mortality in HIV-Infected Patients Starting Antiretroviral Therapy in Africa Geng
Interruption of Maternal-Fetal Transmission of HIV McCune
The Biology of HIV Transmission Hecht
Regulation of ESX-1 Secretion and Its Role in Mycobacterium tuberculosis Virulence Cox
Do Peptide Mimetics of gp41 Improve Antibody-Epitope Interactions? Venditto
Therapeutic Strategies for HIV Disease Havlir
Gene Circuits that Control Morphology in Histoplasma Sil
Host-pathogen Interactions during Vertical Transmission of Listeria monocytogenes Ross
An Automated High Throughput Phenotypic Screen for Schistosomiasis Drug Discovery Caffrey
Impact of CCR5 Blockade in HIV+ Kidney Transplant Recipients Stock
Collaborative Network for Clinical Research on Immune Tolerance - Offcampus Portion Bluestone
Collaborative Network for Clinical Research on Immune Tolerance Bluestone
Evaluating Re-active Surveillance Strategies for Malaria Elimination in Swaziland Hsiang
Structure-Aided Design of CYP51 Inhibitors for Treatment of Parasitic Infections Podust
Mechanisms of Bartonella Virulence in AIDS Patients Koehler
Resistance of Malaria Parasites to Artemisinin-Based Combination Therapies Rosenthal
Reducing Failure-to-Initiate ART: Streamlined ART Start Strategy (START) Havlir
Role of Host Cells in Invasive Listeriosis Bakardjiev
A Novel Proteomic Approach to Tuberculosis Biomarker Discovery using Human Exosomes Davis
Tuberculosis Epidemiology and Novel Transmission Routes in Rural Tanzania Hopewell
Microbial Pathogenesis and Host Defense Engel
Effect of Drug Resistance on Transmissibility and Pathogenicity of M. Tuberculosis Hopewell
Mechansims of poliovirus replication Andino-Pavlovsky
Utility of Contact Investigation of Drug Susceptible and Resistant Tuberculosis in Tanzania Fair
Structural and functional studies of M. tuberculosis type VII secretion Rosenberg
Discovery of novel, ubiquitin-regulated mechanisms of TB control by macrophages Cox
High throughput proteomics to dissect Chlamydia-host cell interactions Engel
Replication, Pathogenesis and Evolution of RNA Viruses, Including Dengue Andino-Pavlovsky
Role of Innate Lymphoid Cells in Autoimmunity Bluestone
Inherited Disorders of Lymphocyte Development Puck
A Clinical Trial for Uncomplicated Skin Infections in Areas of Epidemic Community-Associated Methicillin-Resistant Staphylococcus aureus (MRSA) Chambers
Regulatory Circuits That Link Cell Fate and Virulence in Histoplasma Capsulatum Beyhan-Pelvan
NIH-NIAID - MAC isolates for Study at NIH 20150629 Puck
NK Cell Receptors and Their Ligands Lanier
Genetic Diversity as a Determinant of Viral Adaptation and Pathogenesis Andino-Pavlovsky
Mechanism of enterovirus replication Andino-Pavlovsky
NK and T Cell Costimulation by NKG2D/DAP10 Lanier
Effector and Regulatory T Cell Responses and Protection from Clinical Malaria Feeney
Improving Early Identification of Drug Resistant Tuberculosis in HIV Prevalent Settings Metcalfe
Parasite Immunity Orchestrated by Th2 Cells Locksley
Molecular Dissection of Histoplasma-Induced Host-Cell Death Sil
Heat Shock Protein 90 and HIV Persistence Stoddart
Regulation of Virulence of Cryptococcus neoformans Madhani
Interferon-independent mechanisms of malaria restriction by helper T cells McCune
Human Natural Killer Cell Recognition of Cytomegalovirus Lanier
Bay Area Hepatitis C Cooperative Research Center McCune
Immunomodulation of transplant rejection by anti-CD3 mAb Bluestone
Molecular Epidemiology and Geospatial Analysis of Tuberculosis Transmission in Uganda Chamie
Exploring Statins As a Small Molecule Therapy for Treatment of Schistosomiasis Caffrey
Plasmodium Falciparum Infection and Interference with Effective B Cell Memory Greenhouse
Health Empowerment for MSM in South Africa Lane
Preclinical Development of MucoCept Cohen
The Impact of Tolerance in the Newborn on Lentiviral Infection McCune
Protein homeostasis mechanisms underlying enterovirus replication and evolution Andino-Pavlovsky
DARE: Delaney AIDS Research Enterprise to Find a Cure Deeks
Trefoil Factors Regulate Th2 Immunity Herbert
Reducing Failure-to-Initiate ART: Streamlined ART Start Havlir
Training in HIV Translational Research Havlir
Proteomics Analysis of Host-Pathogen Interactions in Histoplasma Sil
Regulation of Virulence of Cryptococcus neoformans Madhani
Thymic Medullary Epithelial Cell Turnover and Control of Immune Tolerance Anderson
Exploring the Role of Semen Amyloids in Promoting HIV Infection and Fertilization Roan
Novel flow cytometry-based assay for HIV-infected cells McCune
Regulatory circuits and virulence in candida albicans Johnson
Real-Time Unbiased Pathogen Detection in Febrile Illnesses by Nanopore Sequencing Chiu
Novel Mechanisms of Beta-Lactam Resistance in Staph Aureus Chambers
Plugging Hair ARV Levels as Adherence Biomarkers into HIV Prevention Trials Gandhi
Quantitative mapping of interactions between dengue virus and its hosts Shah
Targeting Allosteric Sites to Modulate Protein Interactions and Function Craik
A Novel Microfluidic HIV-1 Co-Culture Assay to Quantify Latent Reservoirs Henrich
Polyclonal Tregs to Promote Tolerance in Pediatric Liver Transplant Recipients Feng
Signaling by Cytoplasmic Tyrosine Kinases in Leukocytes Lowell
Hair measures to assess adherence and explain outcomes in an HIV clinical trial Gandhi
Fetal HCMV Infection: Role of the Human Placenta Pereira
Fetal HCMV Infection: Role of the Human Placenta Pereira
Discovery of Oxaboroles as New Antimalarial Agents Rosenthal
Sexually Transmitted Infections Clinical Trials Group (STICTG) Giudice
Discovery of Oxaboroles as New Antimalarial Agents Rosenthal
Ubiquitylation and the Regulation of Immune Homeostasis Ma
Cryptococcus neoformans Knockout Resource Madhani
HIV cure with CCR5 negative human IPS hematopoietic stem cells Levy
Immunologic Consequences of Highly Effective Antimalarial Chemoprevention Jagannathan
Initiation of allergic immunity by parasites Locksley
Trispecific Monoclonal Antibody for Botulinum Neurotoxin Intoxication Therapy Marks
Impact of HIV-Associated Inflammation on Disease Deeks
Initiation of allergic immunity by parasites Locksley
Bartonella: dissecting niche-specific adaptation in a human pathogen Koehler
Program for Resistance, Immunology, Surveillance, and Modeling of Malaria in Uganda (PRISM) Dorsey
Novel Mechanisms of Beta-lactam Resistance in Staph Aureus, Continuation A120553 Chambers
Program for Resistance, Immunology, Surveillance & Modeling of Malaria in Uganda Dorsey
Bartonella: dissecting niche-specific adaptation in a human pathogen Koehler
Characterization of Gallic Acid as a Novel HIV Microbicide Candidate Roan
Layering of the Human Immune System, Viral Infections, and Childhood Asthma McCune
Newborn Screening for T-Cell Disorders: Spectrum and Outcomes Puck
Biology of Infectious Diseases Training Program Chambers
Recent Advances in AIDS and HIV Research Volberding
UCSF-GIVI Center for AIDS Research (CFAR) Volberding
Recent Advances in AIDS and HIV Research Volberding
Oxygen Sensors and P450 Monooxygenases in Mycobacertium tuberculosis Ortiz De Montellano
Novel approaches to identify host genes required for Chlamydia pathogenesis Engel
Biology of Infectious Diseases Training Program [III] Chambers
BRASL - A rapid Barcoded RNA Annealing, Selection, and Ligation assay to detect pathogens. Chow
The Connie Wofsy Women's HIV Study Greenblatt
Comparison of Pharmacologic Markers of Exposure to HIV Pre-Exposure Prophylaxis Glidden
Cytoskeletal Regulation of T cell Motility and Synaptic Signaling Krummel
Sofosbuvir and Ledipasvir in HIV/HCV Coinfected Pre and Post Liver Transplant Stock
The Connie Wofsy Women's HIV Study Greenblatt
Generation of Therapeutic Antibodies for Serotype F Botulism Marks
TB Surrogate Markers for Assessing Response to Treatment (TB SMART Study) Nahid
TB Surrogate Markers for Assessing Response to Treatment (TB SMART Study) Nahid
Mechanisms of Neutrophil Activation Lowell
Reproductive Tract Effects of the Intrauterine Device: Implications for HIV Risk Smith-McCune
Il-13 and Il-17 Dynamics in the Asthmatic Airway Sheppard
Mechanisms of Neutrophil Activation Lowell
Chemical Methods for Ferrous Iron Dependent Drug Delivery Renslo
Chemical Methods for Ferrous Iron Dependent Drug Delivery Renslo
Interferon gamma-Producing Th17 Subsets: Major Contributors to "Th1" Diseases? Koth
Mobile Health for Implementation of Home-based TB Contact Investigation in Uganda Davis
Chemoprophylaxis for HIV Prevention: Analysis of Bone and Metabolic Effects Glidden
HIV, HCV, and gender effects on Liver, Bone, and Vascular Health Tien
The Bixby Center for Global Reproductive Health - Annual Research Day Conference Chirenje
Novel Mechanisms of Beta-lactam Resistance in Staph Aureus Chambers
Point-of-care C-reactive protein-based tuberculosis screening among people living with HIV: planning a comparative effectiveness trial Yoon
Childhood Tuberculosis Infection Among School-Age Children in Rural Uganda Marquez