NIH National Institute of Allergy and Infectious Disease

56 Active Projects

Title Investigator Start End
Targeting latent HIV-1 Reservoirs with the Antibody-Drug Conjugate, Brentuximab Vedotin Henrich
Resistance of Malaria Parasites to Artemisinin-Based Therapies Rosenthal
Novel Therapeutics for Treatment of River Blindness and Lymphatic Filariasis Sakanari
Identification of diagnostic and prognostic host biomarkers of Zika virus infection by transcriptome profiling Chiu
Cellular and Bacterial Dynamics in Tuberculosis Ernst
Regulation of Innate Immune Signaling by Lyn Kinase Lowell
Timing of ART and homeostasis of the persistent HIV reservoir in the adult McCune
Pharmacodynamics of Antimalarial Chemoprevention Rosenthal
Childhood Tuberculosis Infection Among School-Age Children in Rural Uganda Marquez
Microfluidic PCR Method to Identify and Characterize HIV-Infected Single Cells Henrich
TB Surrogate Markers for Assessing Response to Treatment (TB SMART Study) Nahid
HIV Viral Reservoirs and Monocyte Activation in HIV-Associated Atherosclerosis Hsue
Gene circuits that control morphology in Histoplasma Sil
The impact of TB co-infection on the reservoir of persistent HIV in vivo McCune
Determinants of Functional Immune Defects in Treated HIV Infection and Aging Hunt
Antigen export in M. tuberculosis evasion of CD4 T cells Ernst
Single Cell Characterization of Latent HIV-1 Reservoirs Henrich
Novel methods of pharmacologic monitoring for multidrug resistant tuberculosis treatment in the setting of HIV infection Metcalfe
Impact of Chemotherapy and Stem Cell Transplant on HIV-1 Reservoir Dynamics Henrich
UZ-UCSF Clinical Trials Unit Chirenje
EV71 intra-host evolution, attenuation and vaccine development Andino-Pavlovsky
Discovery of Novel Antimalarial Leads Targeting Translational Repression in Plasmodium parasites Renslo
Using Genetics and Genomics to Dissect Coccidioides Spherulation Sil
Novel serologic assays of P. falciparum exposure for improved surveillance in control and elimination Greenhouse
Effector and regulatory T cell responses and protection from clinical malaria Feeney
Improving the molecular diagnosis of drug resistant tuberculosis Kato-Maeda
Delaney AIDS Research Enterprise to Cure HIV Deeks
Defining the unique properties of the distinct signaling machinery used by the TCR
Training in HIV Translational Research Havlir
Single-cell trancriptomic analysis of HIV infected CD4 cells in blood and lymphoid tissue using PCR activated cell sorting Abate
Adapting to a changing environment: How surface contact induces virulence factor production in Pseudomonas aeruginosa Engel
Simplified Isoniazid Preventive Therapy (SPIRIT) Strategy to Reduce TB Burden Havlir
Hair Extensions;: Using Hair Levels to Interpret Adherence, Effectiveness and Pharmacokinetics with Real-World Oral PrEP, the Vaginal Ring, and Injectables Gandhi
Therapeutic vaccination and PD-1 blockade in treated HIV disease Deeks
Protein secretion in bacterial pathogens Rosenberg
Mentoring in Patient Oriented Research on Food Insecurity, HIV and Aging, Weiser K24 Weiser
Elucidating the mechanism of macrophage death during infection with the AIDS-associated opportunistic pathogen Histoplasma capsulatum Sil
Mentoring Multidisciplinary Patient-Oriented Research in Engagement in HIV Care Geng
The Immunologic Impact of In Utero Malaria Exposure and Prenatal Chemoprevention Prahl
HPMI: Host Pathogen Mapping Initiative Krogan
Sputum Transcriptomic Expression Profiling in Study 31: Express 31 Nahid
Recent Advances in AIDS and HIV Research Volberding
UCSF-Gladstone Center for AIDS Research Volberding
Statistical methods for clinical trials of novel PrEP agents Glidden
Biology of Infectious Diseases Training Program Chambers
The impact of antimalarials and insecticide resistance on malaria transmission in Uganda Conrad
Insect adaptive immunity Andino-Pavlovsky
Point-of-care Urine Monitoring of Adherence (PUMA): Testing a Real-Time Urine Assay of Tenofovir in PrEP Gandhi
Chemical Methods for Ferrous Iron Dependent Drug Delivery Renslo
Placental malaria: The role of inflammation at the maternal-fetal interface Valderramos
Identifying Optimal Treatment Strategies for Tuberculosis Treatment Savic
Mentoring translational scientists in international infectious disease research Greenhouse
Redefining Tuberculosis Meningitis with Metagenomics and Host Transciptomics Wilson
Evaluation of doxycycline post-exposure prophylaxis to reduce sexually transmitted infections in PrEP users and HIV-infected men who have sex with men Luetkemeyer
Program for Resistance, Immunology, Surveillance & Modeling of Malaria in Uganda (PRISM) Renewal Dorsey
Host genetic predictors of plasma IL-1b levels and pharmacogenomics of in vivo IL-1b blockade during treated HIV disease Lee

240 Archived Projects

Title Investigator Start End
San Francisco STDs CRC Padian
Penicillin Interactive Proteins of Staphylococcus Aureus Chambers
Immunomodulation of Transplant Rejection by Anti-CD3 mAb Bluestone
Evaluation of Falcipain as an Antimalarial Drug Target Rosenthal
Population Genetics of the PO1 Locus of SIV and HIV-1 Delwart
Role of Notch 1 in Immunie Tolerance Bluestone
WIHS Treatment Exposure and Viral Rebound Study / AIDS Research Greenblatt
Treatment Intensification for Drug-Resistant HIV Deeks
Rhinoviruses, Epithelial Cells, and Airway Function Boushey
Role of MmpL Transporters in M. Tuberculosis Virulence Cox
Biology of Infectious Diseases Training Program [I] Chambers
Drug Resistant Malaria Clinical and Laboratory Studies Staedke
Predicting Resistance: Validating Mathematical Models Lietman
Adult AIDS Clinical Trials Unit (AACTU) Havlir
STD Risks and Latino Adolescents' Sexual Networks Padian
Role of Innate Immunity in Controlling HIV Infection
UCSF AIDS Research Training Program
T Regulatory Cells and T Cell Activation in HIV Disease Deeks
Recombinant Picornaviruses as AIDS Vaccines Andino-Pavlovsky
Microarray-Based Detection and Typing of Rhinoviruses Boushey
Innate NKT Cells in HIV Infection Nixon
Spontaneous Autoimmune Model of Peripheral Neuropathy Bluestone
Phase 1/2 Trial of Pharmacological HIV-1 Prevention Page
Population-Based Molecular Epidemiology of Tuberculosis Hopewell
The Connie Wofsy Womens' HIV Study Greenblatt
Coming Together to Overcome HIV/AIDS in Zimbabwe and Zambia Padian
The Zimbabwe-San Francisco HIV Prevention Trials Unit Chipato
Double-Stranded RNA Virus in Giardia Wang
Therapeutic Strategies for HIV Disease Havlir
Falcipain Cysteine Proteases of Malaria Parasites Rosenthal
Mechanisms of Bartonella Virulence in AIDS Patients Koehler
Immunologic and Virologic Features of Early HIV Infection
An Intervention for Male STD Patients in India / HIV Related Lindan
Novel Anti-Malarials by Combinatorial Pharmacogenomics Derisi
Utility of Rapid Diagnostic Tests for Malaria Hopkins
Role of Innate Immunity in Controlling HIV Infection
A Chemical Map of T Cell Signaling Shokat
CD4+ T Cell Receptors in Leishmaniasis Locksley
Assessing Laboratory Correlates of Immune Protection McCune
Host Protein Degradation by Schistosome Parasites McKerrow
Regulation of the Development of Tryanosoma brucei Wang
Anti-Gag Antibodies and Enhancement of Lentiviral Disease Progression McCune
Viral Tropism and Immune Control in HIV Nixon
Resistance of Malaria Parasites to Artemisinin-Based Combination Therapies Rosenthal
Regulation of ESX-1 secretion and its role in M. tuberculosis virulence Cox
Regulation of the Development of Trypanosoma brucei Wang
RNA Protein Interactions in Poliovirus Replication Andino-Pavlovsky
Clinical and Molecular Studies of Drug Resistant Malaria [I] Rosenthal
Immunomodulation of Transplant Rejection by Anti-CD3 mAb Bluestone
Thymic Function in Adults With HIV-1 Disease McCune
The Determinants of T Cell Activation in HIV Infection Hunt
Targeting Cysteine Proteases--Antiparasitic Chemotherapy McKerrow
Purine Metabolism in Trichomonas Vaginalis Wang
Host Polymorphisms and Uncomplicated Malaria Parikh
Role of Innate Immunity in Controlling HIV Infection
Training in HIV Translational Research Havlir
An Endogenous Retroelement Vaccine against HIV-1 Nixon
UZ-UCSF Clinical Trials Unit Chirenje
Clinical Studies of Interactions Between HIV and Malaria Havlir
HIV Effects on the Central Hematolymphoid System McCune
Oral Wash for Nucleic Acid Diagnosis and Prognosis of TB in HIV-Infected Ugandans Davis
Mechanisms of Leukocyte Integrin Signaling Lowell
Innate Immune Response Genetics and T cell Activation in Treated HIV Infection Hunt
Immunological Detection and Control of Experimental Uncomplicated Malaria Kim
Protective immunity in HIV Highly Exposed but Uninfected Subjects Nixon
UZ-UCSF Collaborative Research Program Miller
Innovative Methods for Measuring Antiretroviral Exposure Greenblatt
Spontaneous Autoimmune Model of Peripheral Neuropathy Bluestone
Virus Detection Using Microarrays and Characterization of a Novel Cardiovirus Chiu
HPV Epidemiology and Response to Screening (HEARTS) Riley
Oral Wash for Nucleic Acid Diagnosis and Prognosis of TB in HIV-Infected Ugandans Davis
Manipulation of Macrophage Responses by M. tuberculosis Cox
Tissue-Based Small Animal Model for HIV Drug Discovery
Cell Mediated Immunity in HIV-Infected Children Nixon
Dissecting the HLA Contribution to Rheumatoid Arthritis
Role of Innate Immunity in Controlling HIV Infection
HIV Effects on the Central Hematolymphoid System McCune
Dissecting the HLA contribution to Rheumatoid Arthritis
Regulatory T Cell Influence on Infant and Adult Immune Responses to HIV Hartigan-O'Connor
UCSF-GIVI Center for AIDS Research . Volberding
Inflammation, T Cell Senescence, and Mortality in Treated HIV Infection Hunt
Preventing the Establishment of Enfuvirtide-Resistance in the Latent Reservoir Deeks
Molecular Mechanisms of Plasmodium falciparum Adherence to the Human Placenta Fisher
Virologic and Host Factors Contributing to HIV Control in Elite Controllers Hatano
T Regulatory Cells in HIV Infection Nixon
Secretion of Virulence Factors by Mycobacterium tuberculosis Cox
Innate Natural Killer T (NKT) Cells in HIV Infection Nixon
Assessing Antiretroviral Exposure in Diverse Populations Gandhi
Population-Based Molecular Epidemiology of Tuberculosis in San Francisco Hopewell
The Impact of Early Antiretroviral Therapy on HIV Persistence and Inflammation Deeks
Biology of Infectious Diseases Training Program [II] Chambers
The Impact of Early Antiretroviral Therapy on HIV Persistence and Inflammation Deeks
UCSF-Gladstone Center for AIDS Research (CFAR) Volberding
Oxygen Sensors and P450 Monooxgenases in Mycobacterium tuberculosis Ortiz De Montellano
Discovery of Oxaboroles as New Antimalarial Agents Rosenthal
Novel Mechanisms of Beta-Lactam Resistance in Staph aureus Chambers
Spontaneous Autoimmune Model of Peripheral Neuropathy Bluestone
RNAi as an Intercellular Antiviral Defense Mechanism Andino-Pavlovsky
The Connie Wofsy Women's HIV Study Greenblatt
The Impact of CD8 T Cells on Viral Control and Evolution in HIV-Infected Infants Feeney
Translation Regulation in Giardia lamblia Wang
Chemical Methods for Ferrous Iron Targeted Drug Delivery Renslo
HIV Status and Reproductive Aging Affect Liver Fibrosis in HIV/HCV Infected Women Peters
Protective Immunity in HIV Highly Exposed but Uninfected Subjects Nixon
Oral Wash for Nucleic Acid Diagnosis and Prognosis of TB in HIV-infected Ugandans Davis
The Connie Wofsy Women's HIV Study Greenblatt
Initiation of Allergic Immunity by Parasites Locksley
A Rapid Pan-Viral Microarray Diagnostic for Category A-C Biodefense Pathogens Chiu
Sputum M. tuberculosis DNA Kinetics during TB Treatment in Patients with HIV Everett
Immunological Detection and Control of Experimental Uncomplicated Malaria Kim
Translational Studies of Plasmodium Falciparum Infection Dynamics Greenhouse
Resequencing Microarray for Rapid Detection and Antimicrobial Resistance Profiling
Reproductive Infectious Disease (RID) Fellowship Cohen
Development of Botulinum Neurotoxin Immunotherapy, Serotypes C, D, F, and G Marks
HIV cure with CCR5 (-) human IPS hematopoietic stem cells
Global Health Comparative Effectiveness: A Data Synthesis Method Applied to HIV Kahn
Innate NKT Cells in HIV Infection Nixon
Human Endogenous Retroelements in HIV Immunopathogenesis Nixon
A Novel APOBEC-Based Vaccine Approach for HIV Nixon
Regulation of the Development of Trypanosoma brucei Wang
Cervical Maturity, Mucosal Immunity, and Chlamydia trachomatis Infections Hwang
University of Zimbabwe-UCSF Clinical Trials Unit Chirenje
Human Immune System Layering and the Neonatal Response to Vaccines McCune
Genetic Diversity as a Determinant of Viral Pathogenesis and Attenuation Andino-Pavlovsky
The Hair Trigger Study Greenblatt
UCSF HIV Clinical Trials Unit Havlir
TB Guideline Observation and Adherence in Low Income Countries (TB GOAL) Cattamanchi
2013 NIH Workshop on Protein Homeostasis and Viral Infection Andino-Pavlovsky
Lead Identification to Clinical Candidate Selection: Drugs for Chagas' Disease McKerrow
Early Mortality in HIV-Infected Patients Starting Antiretroviral Therapy in Africa Geng
IDO-induced Tryptophan Catabolism and Mortality in Treated HIV-infected Africans Hunt
Interruption of Maternal-Fetal Transmission of HIV McCune
Regulation of ESX-1 Secretion and Its Role in Mycobacterium tuberculosis Virulence Cox
Therapeutic Strategies for HIV Disease Havlir
Gene Circuits that Control Morphology in Histoplasma Sil
Collaborative Network for Clinical Research on Immune Tolerance Bluestone
Collaborative Network for Clinical Research on Immune Tolerance - Offcampus Portion Bluestone
An Automated High Throughput Phenotypic Screen for Schistosomiasis Drug Discovery Caffrey
Host-pathogen Interactions during Vertical Transmission of Listeria monocytogenes Ross
Mechanisms of Bartonella Virulence in AIDS Patients Koehler
Evaluating Re-active Surveillance Strategies for Malaria Elimination in Swaziland Hsiang
Structure-Aided Design of CYP51 Inhibitors for Treatment of Parasitic Infections Podust
A Novel Proteomic Approach to Tuberculosis Biomarker Discovery using Human Exosomes Davis
Tuberculosis Epidemiology and Novel Transmission Routes in Rural Tanzania Hopewell
Resistance of Malaria Parasites to Artemisinin-Based Combination Therapies Rosenthal
Reducing Failure-to-Initiate ART: Streamlined ART Start Strategy (START) Havlir
Microbial Pathogenesis and Host Defense Engel
Effect of Drug Resistance on Transmissibility and Pathogenicity of M. Tuberculosis Hopewell
Mechansims of poliovirus replication Andino-Pavlovsky
High throughput proteomics to dissect Chlamydia-host cell interactions Engel
Structural and functional studies of M. tuberculosis type VII secretion Rosenberg
Utility of Contact Investigation of Drug Susceptible and Resistant Tuberculosis in Tanzania Fair
Replication, Pathogenesis and Evolution of RNA Viruses, Including Dengue Andino-Pavlovsky
Role of Innate Lymphoid Cells in Autoimmunity Bluestone
A Clinical Trial for Uncomplicated Skin Infections in Areas of Epidemic Community-Associated Methicillin-Resistant Staphylococcus aureus (MRSA) Chambers
Regulatory Circuits That Link Cell Fate and Virulence in Histoplasma Capsulatum
Genetic Diversity as a Determinant of Viral Adaptation and Pathogenesis Andino-Pavlovsky
Mechanism of enterovirus replication Andino-Pavlovsky
Improving Early Identification of Drug Resistant Tuberculosis in HIV Prevalent Settings Metcalfe
Effector and Regulatory T Cell Responses and Protection from Clinical Malaria Feeney
Molecular Dissection of Histoplasma-Induced Host-Cell Death Sil
Heat Shock Protein 90 and HIV Persistence
Immunologic Consequences of Highly Effective Antimalarial Chemoprevention Jagannathan
Interferon-independent mechanisms of malaria restriction by helper T cells McCune
Molecular Epidemiology and Geospatial Analysis of Tuberculosis Transmission in Uganda Chamie
Exploring Statins As a Small Molecule Therapy for Treatment of Schistosomiasis Caffrey
Bay Area Hepatitis C Cooperative Research Center McCune
Bartonella: dissecting niche-specific adaptation in a human pathogen Koehler
Preclinical Development of MucoCept Cohen
Trefoil Factors Regulate Th2 Immunity Herbert
The Impact of Tolerance in the Newborn on Lentiviral Infection McCune
Health Empowerment for MSM in South Africa Lane
Training in HIV Translational Research Havlir
Discovery of novel, ubiquitin-regulated mechanisms of TB control by macrophages Cox
Immunomodulation of transplant rejection by anti-CD3 mAb Bluestone
Thymic Medullary Epithelial Cell Turnover and Control of Immune Tolerance
Plugging Hair ARV Levels as Adherence Biomarkers into HIV Prevention Trials Gandhi
Novel Mechanisms of Beta-Lactam Resistance in Staph Aureus Chambers
Novel flow cytometry-based assay for HIV-infected cells McCune
Quantitative mapping of interactions between dengue virus and its hosts Shah
Regulatory circuits and virulence in candida albicans
Signaling by Cytoplasmic Tyrosine Kinases in Leukocytes Lowell
Hair measures to assess adherence and explain outcomes in an HIV clinical trial Gandhi
Fetal HCMV Infection: Role of the Human Placenta Pereira
Sexually Transmitted Infections Clinical Trials Group (STICTG) Giudice
Discovery of Oxaboroles as New Antimalarial Agents Rosenthal
Parasite Immunity Orchestrated by Th2 Cells Locksley
Initiation of allergic immunity by parasites Locksley
Plasmodium Falciparum Infection and Interference with Effective B Cell Memory Greenhouse
Impact of HIV-Associated Inflammation on Disease Deeks
Program for Resistance, Immunology, Surveillance & Modeling of Malaria in Uganda Dorsey
Program for Resistance, Immunology, Surveillance, and Modeling of Malaria in Uganda (PRISM) Dorsey
Protein homeostasis mechanisms underlying enterovirus replication and evolution Andino-Pavlovsky
DARE: Delaney AIDS Research Enterprise to Find a Cure Deeks
Targeting Allosteric Sites to Modulate Protein Interactions and Function Craik
Reducing Failure-to-Initiate ART: Streamlined ART Start Havlir
Layering of the Human Immune System, Viral Infections, and Childhood Asthma McCune
Biology of Infectious Diseases Training Program [III] Chambers
Oxygen Sensors and P450 Monooxygenases in Mycobacertium tuberculosis Ortiz De Montellano
Recent Advances in AIDS and HIV Research Volberding
Biology of Infectious Diseases Training Program Chambers
Novel approaches to identify host genes required for Chlamydia pathogenesis Engel
UCSF-GIVI Center for AIDS Research (CFAR) Volberding
Recent Advances in AIDS and HIV Research Volberding
Interaction between Innate and Th2 Lymphocytes in Helminth Immunity Nussbaum
Real-Time Unbiased Pathogen Detection in Febrile Illnesses by Nanopore Sequencing Chiu
The Connie Wofsy Women's HIV Study Greenblatt
Novel Mechanisms of Beta-lactam Resistance in Staph Aureus Chambers
The Connie Wofsy Women's HIV Study Greenblatt
TB Surrogate Markers for Assessing Response to Treatment (TB SMART Study) Nahid
A Novel Microfluidic HIV-1 Co-Culture Assay to Quantify Latent Reservoirs Henrich
Generation of Therapeutic Antibodies for Serotype F Botulism Marks
Mechanisms of Neutrophil Activation Lowell
New approaches to study Pseudomonas-host interactions Engel
HIV cure with CCR5 negative human IPS hematopoietic stem cells
Chemical Methods for Ferrous Iron Dependent Drug Delivery Renslo
Mechanisms of Neutrophil Activation Lowell
Initiation of allergic immunity by parasites Locksley
Mobile Health for Implementation of Home-based TB Contact Investigation in Uganda Davis
Trispecific Monoclonal Antibody for Botulinum Neurotoxin Intoxication Therapy Marks
Chemoprophylaxis for HIV Prevention: Analysis of Bone and Metabolic Effects Glidden
Bartonella: dissecting niche-specific adaptation in a human pathogen Koehler
HIV, HCV, and gender effects on Liver, Bone, and Vascular Health Tien
Novel Mechanisms of Beta-lactam Resistance in Staph Aureus, Continuation A120553 Chambers
The Bixby Center for Global Reproductive Health - Annual Research Day Conference Chirenje
Proteomics Analysis of Host-Pathogen Interactions in Histoplasma Sil
Chemical Methods for Ferrous Iron Dependent Drug Delivery Renslo
Fetal Zika virus infection: role of the human placenta Pereira
Comparison of Pharmacologic Markers of Exposure to HIV Pre-Exposure Prophylaxis Glidden
Fetal HCMV Infection: Role of the Human Placenta Pereira
Discovery of Oxaboroles as New Antimalarial Agents Rosenthal
Mentoring Translational Researchers for Careers in Pediatric Global Health Feeney
Generation of therapeutic antibodies for serotype F botulism (Continuation of A120963 from NIH G Pool to Subaccount) Marks
Host-Directed Strategies to Create Synergistic Antibacterial Therapies Cox
HIV, HCV, and gender effects on Liver, Bone, and Vascular Health Tien
Childhood Tuberculosis Infection Among School-Age Children in Rural Uganda Marquez
Microbial Pathogenesis and Host Defense Engel
Point-of-care C-reactive protein-based tuberculosis screening among people living with HIV: planning a comparative effectiveness trial Yoon
Evaluation of Novel Tuberculosis Screening Strategies for People living with HIV Yoon
Plugging Hair ARV Levels as Adherence Biomarkers into HIV Prevention Trials Gandhi