NIH National Institute of General Medical Sciences

27 Active Projects

Title Investigator Start End
Systems-level role of GSK3 in colonic epithelium homeostasis and drug resistance Altschuler
Maximizing Opportunities for Research Excellence Watkins
Mechanism of Yeast Transcriptional Regulators Johnson
Structure and mechanism of the dyein motor Vale
Transition zone control of ciliary signaling Reiter
Laying the Foundation of Genomic Enzymology Babbitt
Hepatic degradation of cytochrome P450 enzymes Correia
Modulation of Pulmonary Vascular Permeability and Inflammation by Mesenchymal Stem Cells (MSCs) in Hemorrhagic Shock Pati
Allosteric Regulation in the KDM5 Family of Histone Demethylases Galonic
Testosterone's role in sex-specific outcomes after early anesthesia Sall
A Web-Based Automatic Virtual Screening System Shoichet
A Specific Mechanism for non-specific inhibition Shoichet
Clinical Pharmacology, Drug Action and Pharmacogenetics Burchard
Mapping the conformational cycle of transmembrane transporters Stroud
Molecular Basis for Transmembrane Conduction & Signaling Stroud
IMP: Software for Hybrid Determination of Macromolecular Assembly Structures Sali
Regulation by post-translation modifications in response to stress Toczyski
Structure & Mechanism: microtubule nucleation, centrosomes, phage cytoskeleton Agard
Cellular homeostasis pathways in bacteria Gross
Regulation of Microtubule-Based Motility Vale
Iteratively redefining developmental potential through poised enhancers Blelloch
Rewiring of the pluripotency enhancer network during early mammalian development Blelloch
Development and Testing of New Computational Methods for Ligand Discovery and Mechanism Shoichet
Pharmaceutical Sciences and Pharmacogenomics Kroetz
Protein and small-molecule tools to probe the conformational dependence of the VCP/p97 protein-protein interaction network Arkin
Molecular Basis for Transmembrane Conduction and Signaling Stroud
Medical Scientist Training Program Anderson

63 Archived Projects

Title Investigator Start End
Structural Biology and Targeted Drug Design for AIDS Ortiz De Montellano
Selective Destruction of Cytochrome P450 by Drugs Ortiz De Montellano
Biochemistry and Hepatic Toxicity of Carbon Radicals Ortiz De Montellano
Clinical Pharmacology, Drug Action and Pharmacogenetics Benowitz
Mechanism, Specificity, and Inhibition of Cytocchrome P450 Ortiz De Montellano
Global Genetic Interaction Profiling in Prokaryotes Gross
A Specific Mechanism for Non-Specific Inhibition Shoichet
Microtubule Nucleation: Structure & Mechanism Agard
A Web-Based Automatic Virtual Screening System Shoichet
Hypothermia, Anesthesia, and NMR Metabolomics in Ischemic Neonatal Brain Slices Litt
New Frontiers for Small RNA Therapies McManus
TGFBM2 In Development and Disease Akhurst
Genetic Analysis of the Nucleosome and RNA Polymerase II: a Systems Approach Krogan
Mechanisms of gene silencing Madhani
Characterizing Natural Product Permeability and Bioactivity Lexa
Structure, Function and Inhibition of Beta-Lactamases Shoichet
Clinical Pharmacology, Drug Action and Pharmacogenetics Burchard
Mutational Analysis of E. Coli Core RNA Polymerase Gross
Membrane Protein Expression Center Stroud
Molecular Mechanisms in Development Kornberg
A Toolkit for Light-Control of Molecular Processes in Living Cells Weiner
Enabling New Translational Discoveries Using a Genomic Data-Driven Nosology Butte
IMP: Software for Hybrid Determination of Macromolecular Assembly Structures Sali
MicroRNA Based Pathway Discovery in Cellular Reprogramming Blelloch
Cell Cycle Regulation by Ubiquitin Ligases Toczyski
A Web-Based Automatic Virtual Screening System Shoichet
Integrating computation and genetics to quantify specificity in protein networks Krogan
Center for the Structure of Membrane Proteins Stroud
Function and Pathway Analysis Using Systems-Level Approaches in Prokaryotes Gross
UCSF/UCB Joint Graduate Group in Bioengineering Desai
Pharmacogenomics of Membrane Transporters Giacomini
Mechanism, Specificity, and Inhibition of Cytochrome P450 Ortiz De Montellano
Medical Scientist Training Program Anderson
Microtubule Complexes Involved in Intracellular Transport Vale
Exploration of the Host Genetic Interactions Underlying HIV Infectivity Gordon
Regulation and Targets of the DNA Damage Checkpoint Toczyski
Creating an online resource center for training and professional development in the biomedical sciences Vale
Systematic Phenotypic Analysis of the Gram-positive Envelope Peters
Molecular Basis for Transmembrane Conduction and Signaling Stroud
Centrosome Structure and the Mechanism of Mt Nucleation by Y-Tubulin Complexes Agard
A Specific Mechanism for Non-Specific Inhibition Shoichet
Regulation of the Heat Shock Response in E. coli Gross
Research Training in Chemistry and Chemical Biology Craik
Research Training in Chemistry and Chemical Biology Craik
Signal Integration in Neutrophil Chemotaxis (2 R01 GM084040-06) Weiner
Pharmaceutical Sciences and Pharmacogenomics Kroetz
BMI Bioinformatics Training Grant Babbitt
Pharmaceutical Sciences and Pharmacogenomics Kroetz
Allosteric Inhibition of a Family of Proteolytic Enzymes Craik
HARC Center: HIV Accessory and Regulatory Complexes Frankel
Optogenetic dissection of the growth and activation network in T cells O'donoghue
Mitochondrial Uncoupling and Thermogenesis in Adipose Tissues Kirichok
Hedgehog signaling and signal transduction Kornberg
Gene regulation and function in early embryos Kornberg
Antigen Decoding by T cells Weiner
Mechanism of Gene Silencing Madhani
Molecular Biophysics Training Grant Jacobson
Molecular Biophysics Training Grant (T32 GM008284) Jacobson
Modeling Contact Investigation and Rapid Response Porco
Physical and Genetic Interaction Landscape of the Tyrosine Kinome Krogan
A Pharmacogenomics Study of HIV Latency: The Role of Anti-Programmed Cell Death-1 (PD-1) Signaling Lee
Research Training in Chemistry and Chemical Biology Craik
Design and Experimental Testing of New Docking Methods Shoichet