Many UCSF projects that seek to build capacity and solve research problems with a worldwide scope are based in Northern America, often on UCSF campuses and in university laboratories. Most projects addressing the science of drug screening or development to treat neglected tropical diseases (NTDs) are unfolding in UCSF laboratories at Parnassus or Mission Bay. Likewise, many projects that address the specific health needs or ailments of immigrants and refugees are based in the United States or Canada. In some cases, research on topics such as the immunology of HIV infection may have implications far beyond the San Francisco clinics and laboratories where it is based.