Memory and Aging Center

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Active Projects: 17

Project Investigator All Organizations Start date End date
Predicting progression of human prion disease Michael Geschwind, MD, PhD Memory and Aging Center
The Frontotemporal Lobar Degeneration Clinical Research Consortium Adam Boxer, MD, PhD Memory and Aging Center
TLC-Pre-gPrd: Tracking Longitudinal Change in Presymptomatic genetic Prion Disease Michael Geschwind, MD, PhD Memory and Aging Center
U.S. Army Medical Research Acquisition Activity (USAMRAA) Victor Valcour, MD, PhD Memory and Aging Center
A Multicenter, Multinational, Randomized, Double Blind, Placebo Controlled, Parallel Group Study to Evaluate the Efficacy and Safety of Laquinimod (0.5, 1.0 and 1.5 mg/day) as Treatment in Patients with Huntington's Disease Michael Geschwind, MD, PhD Memory and Aging Center
Interventions for Symptom Management in Older Patients with HAND Victor Valcour, MD, PhD IGHS Faculty Affiliate, Memory and Aging Center, AIDS Research Institute
Traumatic Brain Injury and The Aging Brain: Predictors of Clinical Trajectories Memory and Aging Center
Global Brain Health Institute Victor Valcour, MD, PhD Memory and Aging Center
A Randomized, Double-Blind, Placebo-Controlled, SingleAscending Dose Study to Assess the Safety, Tolerability,and Pharmacokinetics of C2N-8E12 in Subjects withProgressive Supranuclear Palsy Adam Boxer, MD, PhD Memory and Aging Center
Midcareer Mentoring Award for Patient-Oriented Research in HIV and Cognition Victor Valcour, MD, PhD IGHS Faculty Affiliate, Memory and Aging Center, AIDS Research Institute
Effect of Passive Immunization on the Progression of Mild Alzheimer's Disease: Solanezumab(LY2062430) versus Placebo Adam Boxer, MD, PhD Memory and Aging Center
The Four Repeat Tauopathy Neuroimaging Initiative Adam Boxer, MD, PhD Memory and Aging Center
Neuropathological changes underlying clinical heterogeneity in Alzheimer disease Memory and Aging Center
Defining the clinical utility of CSF biomarkers of neurodegeneration in HIV+ elders Memory and Aging Center
Machine learning to distinguish HAND from Alzheimer's disease in HIV over age 60 Victor Valcour, MD, PhD Memory and Aging Center
Phase III multicenter multicenter, randomized, double-blind, placebo controlled, parallel group efficacy and safety study of Crenezumbab in patients with propromal to mild Alzheimers disease Adam Boxer, MD, PhD Memory and Aging Center
ENROLL-HD -A Prospective Registry Study in a Global Huntington's Disease Cohort Michael Geschwind, MD, PhD Memory and Aging Center

Archived Projects: 38

Project Investigator All Organizations Start date End date
California Non-AD Diagnostic Reliability Consortium Julene Johnson, PhD Memory and Aging Center
Cognitive Health and Brain Vulnerability in Aging Insulin Resistant Patients Victor Valcour, MD, PhD Memory and Aging Center
Dementia in HIV Patients over 60 Years of Age Victor Valcour, MD, PhD Memory and Aging Center
Central Nervous System Effects in Acute HIV Seroconversion Victor Valcour, MD, PhD Memory and Aging Center
Early Diagnosis of Human Prion Disease Michael Geschwind, MD, PhD Memory and Aging Center
HIV and Global Drug Therapies: Peripheral Neuropathy Complications and Mechanisms Victor Valcour, MD, PhD Memory and Aging Center
HIV-1 Specific Immune Responses in Thai Individuals with HIV Dementia Victor Valcour, MD, PhD Memory and Aging Center
Biomarker Optimization for Progranulin Trials (The BOPT Study) Adam Boxer, MD, PhD Memory and Aging Center
New Approaches to Dementia Heterogeneity Memory and Aging Center
Neurobiological Predictors of Huntington's Disease (Predict-HD) Michael Geschwind, MD, PhD Memory and Aging Center
BMS-241027 on Cerebrospinal Fluid Biomarkers in Subjects with Mild Alzheimer's Disease Adam Boxer, MD, PhD Memory and Aging Center
Peripheral Reservoir of HIV Monocytes Pivotal to Cognition in HIV Victor Valcour, MD, PhD Memory and Aging Center
Neurobiological Changes in Network Function and Amyloid Deposition in Alzheimer Disease Memory and Aging Center
Eye Movement Control in Normal Elderly and MCI Adam Boxer, MD, PhD Memory and Aging Center
Development of Resting-State FMRI As a Biomarker for Alzheimer Disease Memory and Aging Center
National Alzheimer's Coordinating Center, NACC Memory and Aging Center
An Open Label Dose Finding Study of Nimodipine for the Treatment of Frontotemporal Dementia Due to Progranulin Insufficiency From GRN Gene Mutations Adam Boxer, MD, PhD Memory and Aging Center
A Phase I, Randomized, Double-Blind, Placebo-Controlled, Sequential Cohort, Dose-Ranging Study of the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of TPI-287 in Patients with Mild to Moderate Alzheimer's Disease Adam Boxer, MD, PhD Memory and Aging Center
Neurodevelopment and Imaging among HIV-infected Children from the PREDICT Study Victor Valcour, MD, PhD IGHS Faculty Affiliate, Memory and Aging Center
The Translational Alzheimer Disease Research Program Memory and Aging Center
Four Repeat Tauopathy Neuroimaging Initiative Adam Boxer, MD, PhD Memory and Aging Center
Samples from Brazilian Aging Brain Study Group Memory and Aging Center
Phase II Study to Evaluate the Efficacy and Safety of MABT5102A in Patients with Mild to Moderate Alzheimer's Diseases Adam Boxer, MD, PhD Memory and Aging Center
The Amyotrophic Lateral Sclerosis (ALS)/Parkinsonism-Dementia Complex of Guam: Exploring the Mechanism of a Rare Tauopathy Michael Geschwind, MD, PhD Memory and Aging Center
Extension of Phase II Studies ABE4869g and ABE4955g in Patients with Mild to Moderate Alzheimer Disease Adam Boxer, MD, PhD Memory and Aging Center
Phase I Multiple Ascending Dose Trial of the MT Stabilizer TPI-287 for Alzheimer Disease (AD) Adam Boxer, MD, PhD Memory and Aging Center
Burden, Depression, and Health in Dementia Caregivers: the Role of Emotion Memory and Aging Center
Frontotemporal Dementia: Genes, Images, and Emotions Memory and Aging Center
Long-Term Central Nervous System (CNS) Consequences of Treatment during Acute Infection Victor Valcour, MD, PhD IGHS Faculty Affiliate, Memory and Aging Center
Mechanisms of Spatial Cognitive Impairment in Neurodegenerative Disease Memory and Aging Center
Midcareer Mentoring Award for Patient-Oriented Research in HIV and Cognition Victor Valcour, MD, PhD IGHS Faculty Affiliate, Memory and Aging Center
Therapeutic Interventions during Acute Infection to Address the CNS Reservoir for HIV Victor Valcour, MD, PhD IGHS Faculty Affiliate, Memory and Aging Center
Predicting Progression of Human Prion Disease Michael Geschwind, MD, PhD Memory and Aging Center
Multi-center evaluation of improved RT-QuIC diagnostic assays for Creutzfeldt-Jakob and other human prion diseases Michael Geschwind, MD, PhD Memory and Aging Center
Determinants of Resilience on Youth with HIV Infection and Youth Affected by HIV Victor Valcour, MD, PhD IGHS Faculty Affiliate, Memory and Aging Center
Causes, treatment and prevention of corticobasal degeneration Adam Boxer, MD, PhD Memory and Aging Center
A Double-Blind, Placebo-Controlled, Randomized, Parallel Group, 12-Month Safety and Efficacy Trial of Leuco-methylthioninium bis(hydromethanesulfonate) in Subjects with Behavioral Variant Frontotemporal Dementia (bvFTD) Adam Boxer, MD, PhD Memory and Aging Center
Developing low-cost cognitive tools for dementia assessment in low-to-middle income countries (LMICs) Memory and Aging Center