Memory and Aging Center

Active Projects: 25

Project	Investigator	All Organizations	Start date	End date
Multimodal Imaging in Frontotemporal Degeneration	Howard J. Rosen, MD	Memory and Aging Center	9/1/13	5/31/18
Predicting progression of human prion disease	Michael D. Geschwind, MD, PhD	Memory and Aging Center	7/1/16	5/31/18
Predicting Progression of Human Prion Disease	Michael D. Geschwind, MD, PhD	Memory and Aging Center	8/1/13	6/30/18
Novel imaging and endothelial biomarkers of small vessel cerebrovascular disease		Memory and Aging Center	9/30/16	7/31/18
A Double-Blind, Placebo-Controlled, Randomized, Parallel Group, 12-Month Safety and Efficacy Trial of Leuco-methylthioninium bis(hydromethanesulfonate) in Subjects with Behavioral Variant Frontotemporal Dementia (bvFTD)	Adam L. Boxer, MD, PhD	Memory and Aging Center	7/1/13	12/31/18
New Approaches to Dementia Heterogeneity (P50)	Bruce L. Miller, MD	Memory and Aging Center	4/1/14	3/31/19
Longitudinal Evaluation of Familial Frontotemporal Dementia Subjects (LEFFTDS)	Howard J. Rosen, MD	Memory and Aging Center	9/30/14	5/31/19
Interventions for Symptom Management in Older Patients with HAND	Victor G. Valcour, MD, PhD	IGHS Faculty Affiliate, Memory and Aging Center, AIDS Research Institute	9/26/14	6/30/19
National Alzheimer's Coordinating Center, NACC (Renewal for Y16-20)	Bruce L. Miller, MD	Memory and Aging Center	7/1/14	6/30/19
Determinants of Resilience on Youth with HIV Infection and Youth Affected by HIV	Victor G. Valcour, MD, PhD	IGHS Faculty Affiliate, Memory and Aging Center	9/12/14	7/31/19
The Frontotemporal Lobar Degeneration Clinical Research Consortium	Adam L. Boxer, MD, PhD	Memory and Aging Center	9/30/14	7/31/19
Multidisciplinary Fellowship in Dementia Research	Bruce L. Miller, MD	Memory and Aging Center	5/1/15	4/30/20
A Multicenter, Multinational, Randomized, Double Blind, Placebo Controlled, Parallel Group Study to Evaluate the Efficacy and Safety of Laquinimod (0.5, 1.0 and 1.5 mg/day) as Treatment in Patients with Huntington's Disease	Michael D. Geschwind, MD, PhD	Memory and Aging Center	6/1/15	5/31/20
Biological predictors of brain aging trajectories		Memory and Aging Center	9/1/15	5/31/20
Traumatic Brain Injury and The Aging Brain: Predictors of Clinical Trajectories		Memory and Aging Center	7/15/15	6/30/20
Global Brain Health Institute	Victor G. Valcour, MD, PhD	Memory and Aging Center	7/1/12	6/30/20
A Randomized, Double-Blind, Placebo-Controlled, SingleAscending Dose Study to Assess the Safety, Tolerability,and Pharmacokinetics of C2N-8E12 in Subjects withProgressive Supranuclear Palsy	Adam L. Boxer, MD, PhD	Memory and Aging Center	7/15/15	7/14/20
Understanding the molecular functions of progranulin and granulin in FTLD		Memory and Aging Center	9/15/15	8/31/20
Midcareer Mentoring Award for Patient-Oriented Research in HIV and Cognition	Victor G. Valcour, MD, PhD	IGHS Faculty Affiliate, Memory and Aging Center, AIDS Research Institute	10/15/15	10/14/20
The Four Repeat Tauopathy Neuroimaging Initiative	Adam L. Boxer, MD, PhD	Memory and Aging Center	3/1/16	2/28/21
Neuropathological changes underlying clinical heterogeneity in Alzheimer disease	Lea T. Grinberg, MD, PhD	Memory and Aging Center	8/15/16	5/31/21
Defining the clinical utility of CSF biomarkers of neurodegeneration in HIV+ elders	Joanna Hellmuth, MD, MHS	Memory and Aging Center	7/18/17	6/30/21
Machine learning to distinguish HAND from Alzheimer's disease in HIV over age 60	Victor G. Valcour, MD, PhD	Memory and Aging Center	5/1/17	1/31/22
Phase III multicenter multicenter, randomized, double-blind, placebo controlled, parallel group efficacy and safety study of Crenezumbab in patients with propromal to mild Alzheimers disease	Adam L. Boxer, MD, PhD	Memory and Aging Center	5/5/16	5/31/22
Frontotemporal Dementia: Genes, Images, and Emotions	Bruce L. Miller, MD	Memory and Aging Center	6/1/17	5/31/22

Archived Projects: 43

Project	Investigator	All Organizations	Start date	End date
California Non-AD Diagnostic Reliability Consortium	Julene Johnson, PhD	Memory and Aging Center	7/1/04	6/30/07
Cognitive Health and Brain Vulnerability in Aging Insulin Resistant Patients	Victor G. Valcour, MD, PhD	Memory and Aging Center	7/1/07	6/30/10
Dementia in HIV Patients over 60 Years of Age	Victor G. Valcour, MD, PhD	Memory and Aging Center	9/30/08	7/31/12
Central Nervous System Effects in Acute HIV Seroconversion	Victor G. Valcour, MD, PhD	Memory and Aging Center	7/1/09	5/31/13
Early Diagnosis of Human Prion Disease	Michael D. Geschwind, MD, PhD	Memory and Aging Center	9/1/08	7/31/13
HIV and Global Drug Therapies: Peripheral Neuropathy Complications and Mechanisms	Victor G. Valcour, MD, PhD	Memory and Aging Center	8/1/09	7/31/13
HIV-1 Specific Immune Responses in Thai Individuals with HIV Dementia	Victor G. Valcour, MD, PhD	Memory and Aging Center	8/1/09	7/31/13
Biomarker Optimization for Progranulin Trials (The BOPT Study)	Adam L. Boxer, MD, PhD	Memory and Aging Center	2/1/12	1/31/14
New Approaches to Dementia Heterogeneity	Bruce L. Miller, MD	Memory and Aging Center	5/15/09	3/31/14
Establishing Therapeutic Efficacy in Frontotemporal Degeneration	Howard J. Rosen, MD	Memory and Aging Center	9/30/13	8/31/14
Clinical and biological markers of disease progression in familial FTD	Howard J. Rosen, MD	Memory and Aging Center	9/1/13	8/31/14
Neurobiological Predictors of Huntington's Disease (Predict-HD)	Michael D. Geschwind, MD, PhD	Memory and Aging Center	9/1/12	8/31/14
BMS-241027 on Cerebrospinal Fluid Biomarkers in Subjects with Mild Alzheimer's Disease	Adam L. Boxer, MD, PhD	Memory and Aging Center	10/1/12	9/30/14
Peripheral Reservoir of HIV Monocytes Pivotal to Cognition in HIV	Victor G. Valcour, MD, PhD	Memory and Aging Center	8/1/09	1/31/15
Neurobiological Changes in Network Function and Amyloid Deposition in Alzheimer Disease		Memory and Aging Center	2/1/13	1/31/15
Eye Movement Control in Normal Elderly and MCI	Adam L. Boxer, MD, PhD	Memory and Aging Center	4/1/09	3/31/15
Development of Resting-State FMRI As a Biomarker for Alzheimer Disease	Bruce L. Miller, MD	Memory and Aging Center	6/15/10	5/31/15
National Alzheimer's Coordinating Center, NACC	Bruce L. Miller, MD	Memory and Aging Center	7/1/09	6/30/15
An Open Label Dose Finding Study of Nimodipine for the Treatment of Frontotemporal Dementia Due to Progranulin Insufficiency From GRN Gene Mutations	Adam L. Boxer, MD, PhD	Memory and Aging Center	2/1/13	6/30/15
A Phase I, Randomized, Double-Blind, Placebo-Controlled, Sequential Cohort, Dose-Ranging Study of the Safety, Tolerability, Pharmacokinetics, Pharmacodynamics and Preliminary Efficacy of TPI-287 in Patients with Mild to Moderate Alzheimer's Disease	Adam L. Boxer, MD, PhD	Memory and Aging Center	8/1/13	7/31/15
The Amyotrophic Lateral Sclerosis (ALS)/Parkinsonism-Dementia Complex of Guam: Exploring the Mechanism of a Rare Tauopathy	Michael D. Geschwind, MD, PhD	Memory and Aging Center	8/1/14	7/31/15
U.S. Army Medical Research Acquisition Activity (USAMRAA)	Victor G. Valcour, MD, PhD	Memory and Aging Center	10/1/14	9/30/15
The Translational Alzheimer Disease Research Program	Katherine L. Possin, PhD	Memory and Aging Center	2/1/11	1/31/16
Neurodevelopment and Imaging among HIV-infected Children from the PREDICT Study	Victor G. Valcour, MD, PhD	IGHS Faculty Affiliate, Memory and Aging Center	5/18/10	1/31/16
DoD-ADNI -Effects of TBI and PTSD on AD in Veterans using Imaging and Biomarkers in ADNI	Howard J. Rosen, MD	Memory and Aging Center	2/21/12	2/20/16
Four Repeat Tauopathy Neuroimaging Initiative	Adam L. Boxer, MD, PhD	Memory and Aging Center	9/30/10	5/31/16
Long-Term Central Nervous System (CNS) Consequences of Treatment during Acute Infection	Victor G. Valcour, MD, PhD	IGHS Faculty Affiliate, Memory and Aging Center	7/26/11	5/31/16
Mechanisms of Spatial Cognitive Impairment in Neurodegenerative Disease	Katherine L. Possin, PhD	Memory and Aging Center	7/1/11	6/30/16
Samples from Brazilian Aging Brain Study Group	Lea T. Grinberg, MD, PhD	Memory and Aging Center	7/13/11	7/12/16
Study of Lytico-Bodig disease (Parkinson-dementia complex of Guam)	William W. Seeley, MD	Memory and Aging Center	7/19/11	7/18/16
Phase I Multiple Ascending Dose Trial of the MT Stabilizer TPI-287 for Alzheimer Disease (AD)	Adam L. Boxer, MD, PhD	Memory and Aging Center	8/1/13	7/31/16
Phase II Study to Evaluate the Efficacy and Safety of MABT5102A in Patients with Mild to Moderate Alzheimer's Diseases	Adam L. Boxer, MD, PhD	Memory and Aging Center	8/11/11	8/11/16
The Frontotemporal Lobar Degeneration Neuroimaging Initiative	Howard J. Rosen, MD	Memory and Aging Center	9/30/09	8/31/16
Causes, treatment and prevention of corticobasal degeneration	Adam L. Boxer, MD, PhD	Memory and Aging Center	12/1/13	11/30/16
Effect of Passive Immunization on the Progression of Mild Alzheimer's Disease: Solanezumab(LY2062430) versus Placebo	Adam L. Boxer, MD, PhD	Memory and Aging Center	11/5/13	12/31/16
Extension of Phase II Studies ABE4869g and ABE4955g in Patients with Mild to Moderate Alzheimer Disease	Adam L. Boxer, MD, PhD	Memory and Aging Center	2/5/13	2/4/17
Burden, Depression, and Health in Dementia Caregivers: the Role of Emotion	Bruce L. Miller, MD	Memory and Aging Center	8/15/12	4/30/17
Frontotemporal Dementia: Genes, Images, and Emotions	Bruce L. Miller, MD	Memory and Aging Center	9/1/12	5/31/17
The UCSF and UNMC Dementia Care Ecosystem: Using Innovative Technologies to Personalize and Deliver Coordinated Dementia Care	Bruce L. Miller, MD	Memory and Aging Center	9/1/14	8/31/17
ENROLL-HD -A Prospective Registry Study in a Global Huntington's Disease Cohort	Michael D. Geschwind, MD, PhD	Memory and Aging Center	10/26/12	10/25/17
Midcareer Mentoring Award for Patient-Oriented Research in HIV and Cognition	Victor G. Valcour, MD, PhD	IGHS Faculty Affiliate, Memory and Aging Center	12/6/12	11/30/17
Multi-center evaluation of improved RT-QuIC diagnostic assays for Creutzfeldt-Jakob and other human prion diseases	Michael D. Geschwind, MD, PhD	Memory and Aging Center	2/1/16	1/31/18
Therapeutic Interventions during Acute Infection to Address the CNS Reservoir for HIV	Victor G. Valcour, MD, PhD	IGHS Faculty Affiliate, Memory and Aging Center	5/1/13	4/30/18

Global Health Sciences: Global Research Projects

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Memory and Aging Center

Active Projects: 25

Archived Projects: 43

Active Investigators: 7