Immunology

Active Projects: 47

Project Investigator All Topics Start date End date
Trefoil Factor Proteins Modulate Host Immunity against Hookworms Zoonosis, Emerging Disease, and Drug Resistance, Immunology
Physical and Genetic Interaction Landscape of the Tyrosine Kinome Nevan Krogan, PhD, MSc Cancer/Oncology, Diabetes, Immunology
Functional Manipulation of Memory Regulatory T cells in Skin Cancer/Oncology, Immunology
Microfluidic immunoprofiling for biomarker discovery in rheumatoid arthritis Adam Abate, PhD Immunology
Microbial Pathogenesis and Host Defense Joanne Engel, MD, PhD Immunology, Residencies, Fellowships, and Postdoctoral Training
Role of Antigen-Specific T Cell Responses in the Control of TB Joel D. Ernst, MD Tuberculosis, Immunology
A Pharmacogenomics Study of HIV Latency: The Role of Anti-Programmed Cell Death-1 (PD-1) Signaling Sulggi Lee, MD HIV/AIDS, Immunology
Novel Linkers for Antibody-Drug Conjugates Adam Renslo, PhD Immunology
Integrative Program in Complex Biological System (ipCBS) Joseph Derisi, PhD Drug and Diagnostics Development, Immunology, Genetics, Residencies, Fellowships, and Postdoctoral Training
Investigating Mechanisms of HIV Persistence in the Gut Peter Hunt, MD HIV/AIDS, Immunology
Effect of IL-1B inhibition on inflammation and cardiovascular risk in HIV HIV/AIDS, Immunology
Targeting latent HIV-1 Reservoirs with the Antibody-Drug Conjugate, Brentuximab Vedotin HIV/AIDS, Immunology
Alcohol's impact on immunological and virological profiles in HIV patients Mandana Khalili, MD HIV/AIDS, Immunology, Substance Abuse
Selective AAK1 and GAK inhibitors for combating Dengue and other emerging viral infections Raul Andino-Pavlovsky, PhD Infectious Disease, Zoonosis, Emerging Disease, and Drug Resistance, Immunology
Cellular and Bacterial Dynamics in Tuberculosis Joel D. Ernst, MD Tuberculosis, Immunology
Impact of Cannabis on Inflammation and Viral Persistence in Treated HIV/SIV Peter Hunt, MD HIV/AIDS, Immunology
Regulation of Innate Immune Signaling by Lyn Kinase Immunology
Timing of ART and homeostasis of the persistent HIV reservoir in the adult Mike McCune, MD, PhD HIV/AIDS, Immunology
Immunologic determinants of age-related macular degeneration Peter Hunt, MD Eye Disease and Blindness, Immunology, Aging
Programming Long Term Durable HIV-1 Specific T cell Responses Steven Deeks, MD HIV/AIDS, Immunology
Identification of Cobra-specific antibodies Charles Craik, PhD Zoonosis, Emerging Disease, and Drug Resistance, Immunology
The impact of TB co-infection on the reservoir of persistent HIV in vivo Mike McCune, MD, PhD HIV/AIDS, Tuberculosis, Immunology
Impact of Low IL-10 Levels at Birth and Leukemia Risk Cancer/Oncology, Immunology
Zika virus infection using models of the human placenta Lenore Pereira, PhD Immunology, Newborn and Infant Health
Biomedical simulation models describing how molecular level events effect changes in phenotype C. Anthony Hunt, PhD Immunology, Genetics
Antigen export in M. tuberculosis evasion of CD4 T cells Joel D. Ernst, MD Tuberculosis, Immunology
Developing new vaccines for Global Health applications Margaret Liu, MD Drug and Diagnostics Development, Immunology
Transfusion science and HIV, HTLV, and dengue research in Brazil Philip Norris, MD Infectious Disease, HIV/AIDS, Immunology, Health Systems Strengthening, Risk Reduction and Prevention, Training and Capacity Building
IgA regulation of mucosal biome Keith Mostov, MD, PhD Immunology
Immunology & epidemiology of intestinal infectious diseases Robert Owen, MD Zoonosis, Emerging Disease, and Drug Resistance, Immunology, Epidemiology and Surveillance
Dissecting the effect of paracrine responses to Zika virus on neurodevelopment in the human brain Hanna Retallack, AB Zoonosis, Emerging Disease, and Drug Resistance, Immunology
Single Cell Characterization of Latent HIV-1 Reservoirs HIV/AIDS, Immunology
Allosteric Regulation in the KDM5 Family of Histone Demethylases Immunology
Host-pathogen interactions: Unveiling common mechanisms for rewiring host factors in infectious processes Nevan Krogan, PhD, MSc Infectious Disease, Zoonosis, Emerging Disease, and Drug Resistance, Immunology, Genetics
Effector and regulatory T cell responses and protection from clinical malaria Margaret Feeney, MD Malaria, Drug and Diagnostics Development, Immunology
HIV Cures - Paving the way towards elimination of HIV persistent CD4 T cell in vivo HIV/AIDS, Immunology
Defining the unique properties of the distinct signaling machinery used by the TCR Immunology
Role of proviral loci in HIV latency Adam Abate, PhD HIV/AIDS, Immunology
Precision Targeting of Castration Resistant Prostate Cancer with a Novel Ferrous Iron-Dependent Therapeutic Delivery and Tumor Imaging Strategy Adam Renslo, PhD Cancer/Oncology, Immunology
Long-term Effects of IDU, HIV, HCV and the Impact of HCV Cure on Immune Activation and Liver Fibrosis in Aging Women Phyllis Tien, MD Infectious Disease, HIV/AIDS, Immunology, Women's Health
HPMI: Host Pathogen Mapping Initiative Nevan Krogan, PhD, MSc Zoonosis, Emerging Disease, and Drug Resistance, Immunology, Genetics
Role of Ceramide in Hepatic Stellate Cell Activation and Liver Fibrosis Jennifer Chen, MD Immunology
747-303: A Phase 3, Double-Blind, Randomized, Long-Term, Placebo-Controlled, Multicenter Study Evaluating the Safety and Efficacy of beticholic Acid in Subjects with Nonalcoholic Steatohepatitis Mandana Khalili, MD Immunology
Clinical trials to improve the treatment of drug-sensitive and MDR-TB Patrick Phillips, PhD, MS, MA Tuberculosis, Immunology, Pharmacology and Drug Treatment
Placental malaria: The role of inflammation at the maternal-fetal interface Stephanie Valderramos, MD, PhD Malaria, Immunology, Labor and Delivery, Newborn and Infant Health
Adalimumab in Juvenile Idiopathic Arthritis-associated Uveitis Trial (ADJUST) Nisha Acharya, MD Eye Disease and Blindness, Immunology
Host genetic predictors of plasma IL-1b levels and pharmacogenomics of in vivo IL-1b blockade during treated HIV disease Sulggi Lee, MD HIV/AIDS, Immunology, Genetics, Aging

Active Projects: 103

Project Investigator All Topics Start date End date
Creating Polyketide Antibiotic Diversity by Engineering Cytochrome P450 Enzymes / UC Discovery Immunology
UCSF Comprehensive Center for Immunologic Diseases (CCID) Jeffrey Bluestone, PhD Immunology
Use of r-hGh to Enhance Thymopoiesis and to Facilitate Immune Restoration in Individuals Infected with HIV-1 Mike McCune, MD, PhD HIV/AIDS, Immunology
Effects of Viral Escape on Memory T-Cell Muturation Eric Delwart, PhD Immunology
Phase II Double Blinded, Placebo-Controlled, Efficacy and Safety Evaluation of Allergen Immunotherapy Co-Administered with Omalizumab, an Anti-IgE mAb Jeffrey Bluestone, PhD Immunology
Regulation of Human Thymic Function in Vivo Mike McCune, MD, PhD Immunology
Systematic Review Series on "Antibody and Antigen Detection for the Immunodiagnosis of Tuberculosis" Philip Hopewell, MD Tuberculosis, Immunology, Systematic Reviews and Guideline Development
T Regulatory Cells and T Cell Activation in HIV Disease Steven Deeks, MD HIV/AIDS, Immunology
HIV Controllers: A Potential Model for HIV Eradication Steven Deeks, MD HIV/AIDS, Immunology
HIV Vaccine Trials Network - Laboratory Personnel Support Immunology
Valganciclovir to Reduce T Cell Activation in HIV Infection Peter Hunt, MD HIV/AIDS, Drug and Diagnostics Development, Immunology
Elite Controllers Steven Deeks, MD HIV/AIDS, Immunology, Genetics
CORE B: Intracellular Pathogens and Innate Immunity Joseph Derisi, PhD Tuberculosis, Immunology
Project 2: Effect of Humanized Anti Pcrv Antibody on Total Bacterial Community Composition of Adult Patients with Ventilator-Associated Pneumonia Immunology
Chemoprophylaxis and HIV-Host Interactions [II] HIV/AIDS, Immunology
Immunogenetic Studies of Autoimmune Disease Immunology
Immunological Targeting of APOBEC Proteins to Cure HIV Infection HIV/AIDS, Immunology
Raltegravir Intensification in Antiretroviral-Treated Patients Exhibiting a Suboptimal CD4+T Cell Response Steven Deeks, MD HIV/AIDS, Immunology
Testing novel adjuvants to enhance mucosal immunity elicited by inactivated poliovirus vaccine (IPV) Raul Andino-Pavlovsky, PhD Drug and Diagnostics Development, Immunology
Innate Effector Function and HIV-1 Control Steven Deeks, MD HIV/AIDS, Immunology
Core B: Intracellular Pathogens and Innate Immunity Joseph Derisi, PhD Zoonosis, Emerging Disease, and Drug Resistance, Immunology
Inflammatory and Clinical Consequences of Low-Level Viremia in HIV-1 Infected Patients HIV/AIDS, Immunology
HIV Entry Inhibitors: A New Therapeutic Option Steven Deeks, MD HIV/AIDS, Immunology
CNS Immune / Inflammatory Biomarkers in HIV Controllers Richard Price, MD HIV/AIDS, Immunology
UCSF/Ragon Collaboration on HIV "Elite" Controllers Steven Deeks, MD HIV/AIDS, Drug and Diagnostics Development, Immunology, Genetics
Siglec-F and Resolution of Allergic Inflammation Homer Boushey, MD Immunology, Genetics
Treating HIV-Infected Elite Controllers as a Model of HIV Remission HIV/AIDS, Immunology
Identification of the CD8+ Cell Anti-HIV Factor (CAF) HIV/AIDS, Immunology
Characterizing the Role of Immune Activation in HIV Persistence Steven Deeks, MD HIV/AIDS, Immunology
HLA-A Low Resolution Typing Surgery and Anesthesia, Immunology
Initiation of Allergic Immunity by Parasites Richard Locksley, MD Immunology
Development of Human mAbs to Target Cardiomyocytes and Cardiac Fibroblasts Cardiovascular Disease, Immunology
Childhood Arthritis and Rheumatology Research Alliance Registry (CARRA Registry): Lupus Nephritis Consensus Treatment Plan Maintenance Phase Immunology
DNA methylation profiling in Rheumatoid Arthritis Immunology
Effects of CCR5 - delta-32 Heterozygosity on the HIV-1 Reservoir Steven Deeks, MD HIV/AIDS, Immunology, Genetics
Global Innate Immune Responses to HIV-1 Infection Nevan Krogan, PhD, MSc HIV/AIDS, Immunology
Health Professional Research Preceptorship Immunology
Development of Regulatory T-Cells for Treatment of Autoimmune Disease Jeffrey Bluestone, PhD Immunology, Pharmacology and Drug Treatment
Stem Cell differentiation to thymic epithelium for inducing immune tolerance to stem cells Immunology
Development of Human mABs to CXCR1 and CXCR2 Immunology
Recent Thymic Emigrants of the CD4 T-Cell Lineage Mike McCune, MD, PhD Immunology
A 6 month Multi-center, Open-label Safety Study of VIMOVO in Adolescents Immunology, Adolescent Health
Genome-Wide Association Study to Examine Genes Associated with An Increased Risk of Febrile Seizure in Children Following Measles-Containing Vaccines Mark Seielstad, PhD Infectious Disease, Transfusion Medicine, Immunology, Pharmacology and Drug Treatment, Pediatrics, Epidemiology and Surveillance
Mechanisms of B Cell Responses in Autoimmune Disease: C12-ALE05-CSF Immunology
Collaborative Network for Clinical Research on Immune Tolerance - Offcampus Portion Jeffrey Bluestone, PhD Diabetes, Immunology
Collaborative Network for Clinical Research on Immune Tolerance Jeffrey Bluestone, PhD Diabetes, Immunology
Gender-specific Differences Affecting Reactivation of Latent HIV in Treated Patients Steven Deeks, MD HIV/AIDS, Immunology, Women's Health
A Novel Myeloid Subset Mediating Tolerance to Malaria Malaria, Immunology
Identifying and targeting HIV persistence in T Cell subsets during ART Steven Deeks, MD Drug and Diagnostics Development, Immunology, Genetics
Health Professional Research Preceptorship Immunology, Residencies, Fellowships, and Postdoctoral Training
Health Professional Research Preceptorship Immunology, Residencies, Fellowships, and Postdoctoral Training
Genetic Diversity as a Determinant of Viral Adaptation and Pathogenesis Raul Andino-Pavlovsky, PhD Infectious Disease, Immunology
UCSF Cutaneous Immunology Core: OSM Project Opportunistic Infection, Cancer/Oncology, Immunology
Mechanisms of B Cell Responses in Autoimmune Disease Oral Health, Immunology
Interferon-independent mechanisms of malaria restriction by helper T cells Mike McCune, MD, PhD HIV/AIDS, Malaria, Immunology
Medical and Graduate Student Preceptorship - Mok Immunology, Residencies, Fellowships, and Postdoctoral Training
Exploring the role of a novel, polymorphic protein family in M. tuberculosis pathogenesis Tuberculosis, Immunology
Trefoil Factors Regulate Th2 Immunity Zoonosis, Emerging Disease, and Drug Resistance, Neglected Tropical Diseases (NTDs), Immunology
Reactivation of latent HIV using recombinant galectin-9 HIV/AIDS, Immunology
Discovery of novel, ubiquitin-regulated mechanisms of TB control by macrophages Tuberculosis, Immunology
Treatment of SLE with ajulemic acid,a non-psychoactive cannabinoid derivative Immunology
The ONE Study: A Unified Approach to Evaluating Cellular Immunotherapy in Solid Organ Transplantation Jeffrey Bluestone, PhD Immunology
Immunomodulation of transplant rejection by anti-CD3 mAb Jeffrey Bluestone, PhD Immunology
Quantitative mapping of interactions between dengue virus and its hosts Zoonosis, Emerging Disease, and Drug Resistance, Immunology
A Specific Mechanism for Non-Specific Inhibition Immunology
Enabling New Translational Discoveries Using a Genomic Data-Driven Nosology Atul Butte, MD, PhD Cancer/Oncology, Immunology
Mass Spectrometry Tools in Pursuit of Salivary Biomarkers of Sjogren Syndrome Oral Health, Immunology
HIV-Specific T-Cell Responses in Rectal Mucosa Elizabeth Sinclair, PhD HIV/AIDS, Immunology
Plasmodium Falciparum Infection and Interference with Effective B Cell Memory Bryan Greenhouse, MD Malaria, Immunology, Pediatrics
NP25737 A Phase I Pharmacokinetic and Safety Study of Tocilizumab (TCZ) in Patients Less Than 2 Years Old With Active Systemic Juvenile Idiopathic Arthritis Noncommunicable and/or Chronic Disease, Immunology, Pediatrics
Defining critical events in early HIV infection-effects of alcohol and early ART Mike McCune, MD, PhD HIV/AIDS, Immunology, Substance Abuse
University of California Global Health Institute Program for Fellows and Scholars Craig Cohen, MD, MPH Sexually Transmitted Infections (STIs), Zoonosis, Emerging Disease, and Drug Resistance, Neglected Tropical Diseases (NTDs), HIV/AIDS, Opportunistic Infection, Tuberculosis, Malaria, Noncommunicable and/or Chronic Disease, Surgery and Anesthesia, Cancer/Oncology, Cardiovascular Disease, Chronic Respiratory Disease, Diabetes, Occupational and Environmental Disease, Diet, Exercise, and Obesity, Malnutrition, Micronutrients, Food Insecurity, Eye Disease and Blindness, Oral Health, Drug and Diagnostics Development, Immunology, Genetics, Pharmacology and Drug Treatment, Neurology and Mental Health, Dementia and Cognitive Impairment, Trauma and PTSD, Women's Health, Aging, Labor and Delivery, Family Planning, Pediatrics, Newborn and Infant Health, Adolescent Health, Health Economics and Effectiveness, Access or Barriers to Care, Immigration and Migration, Stigma and Discrimination, Smoking and Tobacco, Policy and Standards of Care, Systematic Reviews and Guideline Development, Epidemiology and Surveillance, Triangulation, Global Strategic Information, Implementation and Behavioral Science, Engagement in Care, Substance Abuse, Treatment Adherence, Health Systems Strengthening, Risk Reduction and Prevention, Residencies, Fellowships, and Postdoctoral Training
A pilot study of DNA methylation and response to treatment in RA Immunology
Elucidating the Fundamental Biology of Memory Regulatory T cells in Skin Cancer/Oncology, Immunology
Placental Malaria: The Role of Macrophages in Placental Inflammation - RSDP Valderramos Burroughs Wellcome Fund Stephanie Valderramos, MD, PhD Malaria, Immunology
UCSF-GIVI Center for AIDS Research (CFAR) Paul Volberding, MD HIV/AIDS, Tuberculosis, Malaria, Cancer/Oncology, Cardiovascular Disease, Drug and Diagnostics Development, Immunology, Pharmacology and Drug Treatment, Neurology and Mental Health, Trauma and PTSD, Women's Health, Pediatrics, Implementation and Behavioral Science, Training and Capacity Building, Training International Scholars and Clinicians
Optogenetic dissection of the growth and activation network in T cells Immunology
Oxygen Sensors and P450 Monooxygenases in Mycobacertium tuberculosis Tuberculosis, Immunology
HARC Center: HIV Accessory and Regulatory Complexes Alan Frankel, PhD Zoonosis, Emerging Disease, and Drug Resistance, HIV/AIDS, Immunology
Placental Malaria: The Role of Macrophages in Placental Inflammation - RSDP Valderramos Stephanie Valderramos, MD, PhD Malaria, Immunology
Mother-child genetic contributions to autoimmunity Immunology
Improve the Cho Expression of a ScFv Fragment by Optimizing the DNA Sequence of the ingle chain variable fragment ScFv and/or Leader Sequence Drug and Diagnostics Development, Immunology
Antigen Decoding by T cells Immunology
Vertical Transmission of Zika Virus: Histopathological Investigations at the Maternal- Fetal Interface Stephanie Valderramos, MD, PhD Infectious Disease, Drug and Diagnostics Development, Immunology
HIV cure with CCR5 negative human IPS hematopoietic stem cells HIV/AIDS, Drug and Diagnostics Development, Immunology
Mechanisms of Neutrophil Activation Immunology
Gilead Sciences Research Scholars Program in Cystic Fibrosis. Oren Rosenberg, MD, PhD Immunology
HINT: HIV Immune Networks Team Modeling Core Nevan Krogan, PhD, MSc HIV/AIDS, Immunology
Initiation of allergic immunity by parasites Richard Locksley, MD Immunology
ACTG A5335s Specialty Lab Diane Havlir, MD Drug and Diagnostics Development, Immunology, Genetics
BSL3 upgrading for Live-attenuated poliovirus testing Raul Andino-Pavlovsky, PhD Infectious Disease, Immunology
Enhancing Control of HIV by Inhibiting TRAIL Steven Deeks, MD HIV/AIDS, Drug and Diagnostics Development, Immunology
Pets and the Infant Microbiome: Effect on Immune Maturation and Atopic Asthma Occupational and Environmental Disease, Immunology
Allosteric Inhibition of a Family of Proteolytic Enzymes Charles Craik, PhD Immunology, Pharmacology and Drug Treatment
Proteomics Analysis of Host-Pathogen Interactions in Histoplasma Anita Sil, MD, PhD Opportunistic Infection, Immunology
Antigen Specificity of Regulatory T cells in Type 1 diabetes T1D Jeffrey Bluestone, PhD Diabetes, Immunology
Impact of interferon-alpha inhibition on immune function and viral persistence in HIV disease Steven Deeks, MD HIV/AIDS, Immunology
New ways of treating pancreatic cancer based on reversing K-Ras-mediated stemness Cancer/Oncology, Immunology
VEGF signaling in placental development and disease Susan Fisher, PhD Immunology, Labor and Delivery
Naturally acquired immunity to norovirus in a newborn cohort in Peru Caryn Bern, MD, MPH Infectious Disease, Immunology, Newborn and Infant Health
Host-Directed Strategies to Create Synergistic Antibacterial Therapies Zoonosis, Emerging Disease, and Drug Resistance, Tuberculosis, Drug and Diagnostics Development, Immunology
HIV-Specific T-Cell Responses in Rectal Mucosa Peter Hunt, MD Immunology
Generation of therapeutic antibodies for serotype F botulism (Continuation of A120963 from NIH G Pool to Subaccount) Immunology