The HIV/AIDS Division is globally engaged in research and education around the world. They have established partnerships that lead work to address the most pressing issues of the HIV epidemic in resource limited settings. They are committed and actively training the next generation of HIV researchers from countries most affected by HIV. Ongoing projects span from understanding disease pathogenesis to epidemiology to treatment to models of care delivery. The HIV/AIDS DIvision co-directs the Makerere University–UCSF research collaboration which has enrolled over 20,000 patients on clinical studies evaluating HIV, TB, malaria, and nutrition.

Major components of that collaboration include:

• ICEMR/PRISM  (International Center of Excellence for Malaria Research /Program for Resistance, Immunology, Surveillance and Modeling of Malaria in Uganda): a global network of independent research centers in malaria-endemic settings to provide knowledge, tools, and evidence-based strategies to support researchers working in a variety of settings, especially within governments and healthcare institutions. 
• SEARCH (Sustainable East Africa Research on Community Health): evaluating the health, education and economic outcomes of novel community based interventions in a "test and treat" approach that includes HIV as well as non-communicable diseases such as hypertension.
• UMSP (Uganda Malaria Surveillance Project): a multi-site surveillance system for monitoring antimalarial drug efficacy and safety, malaria related morbidity and mortality and building capacity for facility based management of malaria.