All Centers of Excellence (CoE) are designed to provide a comprehensive HIV care and support services, including primary HIV medical care, case management, outpatient mental health, outpatient substance abuse, and treatment advocacy. Some CoE have additional specialty services. CoE vary in terms of size, location and expertise in the needs of specific populations. Any qualifying client may receive services from the CoE of his/her choice. The San Francisco Centers of Excellence network forges a new type of "safety net" for severe need and special populations. Currently, HHS funds seven CoE.

 CHRONIC CARE HIV/AIDS MULTIDISCIPLINARY PROGRAM (CCHAMP)
This CoE focuses on services to men who have sex with men (MSM); Latino, African American and transgender women; immigrants with a focus on undocumented Spanish-speaking persons. Service locations include the Mission/Potrero Hill area, South of Market, Upper Van Ness and Castro districts. The lead agency is the University of California in San Francisco: Positive Health Program at San Francisco General Hospital.