ACE-Inhibitors to Decrease Lymphoid Fibrosis and the Size of the Latent Reservoir in Antiretroviral-Treated, HIV-infected Patients: A Randomized, Placebo-Controlled Study

Sponsor: Merck and Co., Inc.

Location(s): United States


The investigators propose a proof-of-concept, pathogenesis-oriented, randomized, placebo-controlled pilot study to assess whether the addition of an angiotensin converting enzyme (ACE) inhibitor to standard Highly Active Antiretroviral Therapy (HAART) reverses lymphoid fibrosis, and whether this leads to more effective HIV-specific host immune responses and an accelerated clearance of the latent reservoir.