Center for Discovery and Innovation in Parasitic Diseases (CDIPD)

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Location(s): Africa; China; Southern Asia; South-Eastern Asia; Western Asia; Central America; Mexico; Brazil; Caribbean; Palau

Description

The Center for Discovery and Innovation in Parasitic Diseases (CDIPD) is an interdisciplinary research center started at UCSF, and continuing with collaboarations at UCSD. CDIPD targets diseases affecting hundreds of millions of people worldwide, but which are largely ignored by traditional drug and vaccine discovery companies because they primarily affect the poor and underserved.

 

Archived Projects: 36

Project Investigator Topics Location Start End
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A Genome Wide Characterization of the Erythrocytic Cell Cycle of the Human Parasite Plasmodium Joseph Derisi, PhD Malaria United States
High Throughput Assay for Screening Compounds Against T. Brucei Zoonosis, Emerging Disease, and Drug Resistance, Neglected Tropical Diseases (NTDs), Drug and Diagnostics Development, Pharmacology and Drug Treatment United States
Optimization of Cysteine Protease Inhibitors Targeting Trypanosoma Brucei Zoonosis, Emerging Disease, and Drug Resistance, Neglected Tropical Diseases (NTDs), Drug and Diagnostics Development, Pharmacology and Drug Treatment United States
Schistosoma mansoni: Identification and Validation of New Targets for Therapy Using a siRNA Screen Zoonosis, Emerging Disease, and Drug Resistance, Neglected Tropical Diseases (NTDs) United States
Falcipain Cysteine Proteases of Malaria Parasites Philip J. Rosenthal, MD Malaria United States
Host Protein Degradation by Schistosome Parasites Zoonosis, Emerging Disease, and Drug Resistance, Neglected Tropical Diseases (NTDs), Drug and Diagnostics Development, Pharmacology and Drug Treatment United States
Transcriptional Responses of Parasite and Host during Intestinal Colonization and Invasion by Entamoeba histolytica Zoonosis, Emerging Disease, and Drug Resistance, Neglected Tropical Diseases (NTDs), Drug and Diagnostics Development, Pharmacology and Drug Treatment Mexico
Clinical and Molecular Studies of Drug Resistant Malaria [I] Philip J. Rosenthal, MD Malaria Uganda
Targeting Cysteine Proteases--Antiparasitic Chemotherapy Zoonosis, Emerging Disease, and Drug Resistance, Neglected Tropical Diseases (NTDs), Drug and Diagnostics Development, Pharmacology and Drug Treatment United States
Identification of Novel Small Molecule Therapeutics for Visceral Leishmaniasis Adam Renslo, PhD Zoonosis, Emerging Disease, and Drug Resistance, Neglected Tropical Diseases (NTDs) United States
Trypanosome Drug Development Consortium Zoonosis, Emerging Disease, and Drug Resistance, Neglected Tropical Diseases (NTDs), Drug and Diagnostics Development United States
Iron-Dependent Drug Delivery as a New Paradigm in Anti-Parasitic Chemotherapy and Prophylaxis Adam Renslo, PhD Zoonosis, Emerging Disease, and Drug Resistance, Neglected Tropical Diseases (NTDs), Drug and Diagnostics Development United States
Trial of T.cruzi DNA Vaccine in Experimental Model of Disease Challenge Infection Zoonosis, Emerging Disease, and Drug Resistance, Neglected Tropical Diseases (NTDs), Drug and Diagnostics Development
RNA Interference and High-Content Image Analysis to Discover New Drug Targets to Treat the Tropical Disease Schistosomiasis Neglected Tropical Diseases (NTDs), Drug and Diagnostics Development Mexico
Translational Studies of Antimalarial Drug Resistance Philip J. Rosenthal, MD Zoonosis, Emerging Disease, and Drug Resistance, Malaria Uganda
Identification of Novel Therapeutics Molecules against Old and New World Cutaneous Leishmaniasis Adam Renslo, PhD Drug and Diagnostics Development United States
A New Field Assay to Diagnose and Monitor Schistosomiasis Sexually Transmitted Infections (STIs), Zoonosis, Emerging Disease, and Drug Resistance, Drug and Diagnostics Development
Chemical Methods for Ferrous Iron Targeted Drug Delivery Adam Renslo, PhD Zoonosis, Emerging Disease, and Drug Resistance, Malaria United States
Novel Therapeutics for Class B Protozoa Neglected Tropical Diseases (NTDs)
Stanford Global Health Consortium: Innovation, Design, Evaluation and Action United States
K777 for the Treatment of Chagas' Disease, IND-enabling Studies and IND Submission Neglected Tropical Diseases (NTDs), Drug and Diagnostics Development United States
Trial of T.cruzi DNA Vaccine in Experimental Model of Disease Challenge Infection Neglected Tropical Diseases (NTDs) United States
Broad-UCSF Visceral Leishmania Screening Collaboration Neglected Tropical Diseases (NTDs) United States
Broad Spectrum Antivirals Targeting Envelope Proteolysis and Viral Uncoating Zoonosis, Emerging Disease, and Drug Resistance, Neglected Tropical Diseases (NTDs), Drug and Diagnostics Development United States
Chemicals with Potential Activity against Malaria Parasites Philip J. Rosenthal, MD Malaria, Drug and Diagnostics Development
Student and Postdoctoral Collaborations Travel Award Zoonosis, Emerging Disease, and Drug Resistance, Neglected Tropical Diseases (NTDs), Residencies, Fellowships, and Postdoctoral Training Brazil
Lead Identification to Clinical Candidate Selection: Drugs for Chagas' Disease Neglected Tropical Diseases (NTDs), Drug and Diagnostics Development Brazil
Structure and Engineering of Natural Product Cytochrome P450 Neglected Tropical Diseases (NTDs), Drug and Diagnostics Development United States
An Automated High Throughput Phenotypic Screen for Schistosomiasis Drug Discovery Infectious Disease, Neglected Tropical Diseases (NTDs), Drug and Diagnostics Development United States
Structure-Aided Design of CYP51 Inhibitors for Treatment of Parasitic Infections Zoonosis, Emerging Disease, and Drug Resistance, Neglected Tropical Diseases (NTDs), Drug and Diagnostics Development United States
Resistance of Malaria Parasites to Artemisinin-Based Combination Therapies Philip J. Rosenthal, MD Zoonosis, Emerging Disease, and Drug Resistance, Malaria Uganda; Burkina Faso
Schistosome Research Neglected Tropical Diseases (NTDs), Drug and Diagnostics Development United States
Exploring Statins As a Small Molecule Therapy for Treatment of Schistosomiasis Neglected Tropical Diseases (NTDs), Noncommunicable and/or Chronic Disease, Risk Reduction and Prevention United States
Developing a Macrofilaricidal Drug for Onchocerciasis Using Anacor's Novel Oxaborole Technology Neglected Tropical Diseases (NTDs), Drug and Diagnostics Development United States
Chemical Methods for Ferrous Iron Dependent Drug Delivery Adam Renslo, PhD Zoonosis, Emerging Disease, and Drug Resistance, Neglected Tropical Diseases (NTDs), Drug and Diagnostics Development United States
Evolution and Inhibition of Serine Beta-Lactamase Activity Adam Renslo, PhD Opportunistic Infection, Drug and Diagnostics Development United States