RNA Interference and High-Content Image Analysis to Discover New Drug Targets to Treat the Tropical Disease Schistosomiasis
Sponsor: University of California Institute for Mexico and the U.S. (UC MEXUS)
The possible emergence of resistance to the only available drug for schistosomiasis spurs drug discovery that has been recently incentivized by the availability of improved transcriptome and genome sequence information. Transient RNAi has emerged as a straightforward and important technique to interrogate that information through decreased or loss of gene function and identify potential drug targets. Developing this technology will facilitate larger scale screening of drugs.