We are pursing translational studies of antimalarial drug resistance. Aims include characterization of molecular mechanisms of drug resistance and elaboration of the selection of resistance by drugs used for the treatment of malaria, the prevention of malaria, or the treatment of HIV infection. Studies include molecular characterization of malaria parasites, in vitro evaluation of responsiveness to antimalarial drugs, and molecular studies to characterize the impacts of key parasite polymorphisms on antimalarial drug efficacy and parasite fitness. These studies are conducted both at UCSF and in Uganda. Contact: Philip Rosenthal, MD