Gestational Dating at Birth by Metabolic Profile: Translation into Hospital Settings

Investigator: Laura Jelliffe, PhD, MS
Sponsor: Bill & Melinda Gates Foundation

Location(s): United States


Accurate gestational dating is a critical component of obstetric and newborn care. In the absence of early ultrasound, many clinicians rely on less accurate measures, such as last menstrual period or symphysis-fundal height during pregnancy, or Dubowitz scoring or the Ballard (or New Ballard) method at birth. These measures often underestimate or overestimate gestational age and can lead to misclassification of babies as born preterm, which has both short- and long-term clinical care and public health implications.

We seek to evaluate whether metabolic markers in newborns measured as part of routine screening can be used to develop a population-level metabolic gestational dating algorithm that can be used when fetal ultrasound dating is not available.