Uncovering How Mycobacterium Tuberculosis Utilizes a Novel Protein Secretion System to Manipulate Host Response During Infection

Sponsor: William M. Keck Foundation

Location(s): United States


Bacterial pathogens trigger specialized virulence factor secretion systems on encountering host cells. The ESX-1 protein secretion system of Mycobacterium tuberculosis—the causative agent of the human disease tuberculosis—delivers bacterial proteins into host cells during infection and is critical for virulence, but how it is regulated is unknown.