Systems Pharmacology Approaches to Understanding Drug Induced Weight Gain

Sponsor: Burroughs Wellcome Fund

Location(s): United States


A systems pharmacological approach that capitalizes on the characterization of intracellular signaling networks can transform our understanding of human diseases and lead to therapy development. This study will apply this strategy to identify pharmacological targets for the treatment of drug-induced weight gain, a serious side effect of many commonly used drugs leading to noncompliance with therapy and to exacerbation of comorbid conditions related to obesity.