This project focuses the expertise of UCSF and HDFCCC in the area of global health on the problem of esophageal cancer (EC) and its suspected high incidence in Eastern Africa. In collaboration with colleagues in Tanzania, we will focus on the cancer burden from EC by carrying out the following aims:
(1) to determine the age-standardized incidence and age-adjusted survival rates for EC diagnosed between 2004 and 2008 in four urban area in Eastern Africa represented by population-based cancer registries;
(2) to perform a retrospective chart review of all cases of EC identified by the Tanzania Cancer Registry (TCR) in Dar es Salaam in 2012 and 2013 to determine distribution of disease stage at diagnosis; and
(3) to perform a case-control study to determine the potential etiologic effect of dietary, other lifestyle, and environmental factors in the development of EC in Dar es Salaam.