Streamlined TB Diagnosis

Investigator: Adithya Cattamanchi, MD
Sponsor: London School of Hygiene & Tropical Medicine

Location(s): Uganda


Smear-positive tuberculosis (TB) case detection rates are far below targets in most low-income countries. The standard approach to smear microscopy involves sputum collection over multiple days and examination of sputum smears by light microscopy (LM), an insensitive and time-consuming technique.

This project aims to  determine whether alternative approaches can increase smear-positive case detection by increasing the efficiency (single-specimen microscopy) or sensitivity (light-emitting diode [LED] fluorescence microscopy [FM]) of TB suspect evaluation.