The prevalence of chorioamnionitis among HIV infected and uninfected pregnant Ugandan women and its association with preterm birth

Investigator: John Ategeka
Sponsor: UCSF Preterm Birth Initiative (PTBi)

Location(s): Uganda


GBS is linked to chorioamnionitis, and incidence of neonatal infection with GBS has decreased significantly in countries that provide intrapartum antibiotic prophylaxis after screening as standard of care. This algorithm is not currently part of clinical practice in Uganda, and its potential benefit to the population is unknown. This study is designed to generate data that could lead to practice changes, especially GBS carrier testing and prophylaxis.

Methods include: histopathology from the placental membrane, umbilical cord and chorionic plate; immunohistochemistry for GBS; and confirmatory PCR for positive cases.