Nonlinear Mixed Effects Modeling of Rifapentine in Children
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Investigator: Rada Savic, PhD
Sponsor: National Foundation for the CDC and Prevention
Location(s): Kenya; South Africa; China; Viet Nam; Peru
Description
We will perform nonlinear mixed effects (NLME) modeling of TBTC Study data to evaluate:
– Autoinduction and its relationship to dose
– Drug/metabolite relationships
– Absorptionandclearance kinetics/saturability and relationship to dose