Nonlinear Mixed Effects Modeling of Rifapentine in Children

Investigator: Rada Savic, PhD
Sponsor: National Foundation for the CDC and Prevention

Location(s): Kenya; South Africa; China; Viet Nam; Peru


We will perform nonlinear mixed effects (NLME) modeling of TBTC Study data to evaluate:

– Autoinduction and its relationship to dose

– Drug/metabolite relationships

– Absorptionandclearance kinetics/saturability and relationship to dose