The scientific evidence linking environmental exposures to adverse health outcomes has yet to be compiled using systematic methods with the capacity to inform effective healthcare and policy decision-making. To bridge the gap between clinical and environmental health sciences, PRHE has undertaken an interdisciplinary collaboration to develop a systematic and transparent methodology to evaluate the quality of evidence and strength of recommendations about the relationship between the environment and reproductive health. The result of this collaboration---the Navigation Guide--- was published in the May 2011 issue of the journal Health Affairs.