Interventions for Improving Retention in Antiretroviral Therapy (ART) Programs (PO 200988865)

Investigator: George Rutherford, MD
Sponsor: World Health Organization (WHO)

Location(s): Burundi; Comoros; Djibouti; Eritrea; Ethiopia; Kenya; Madagascar; Malawi; Mauritius; Mozambique; Rwanda; Seychelles; Somalia; South Sudan; Uganda; Tanzania; Zambia; Zimbabwe; Angola; Cameroon; Central African Republic; Chad; Congo (Kinshasa); Congo (Brazzaville); Equatorial Guinea; Gabon; Sao Tome and Principe; Algeria; Egypt; Libya; Morocco; Sudan; Tunisia; Western Sahara; Botswana; Lesotho; Namibia; South Africa; Swaziland; Benin; Burkina Faso; Cape Verde; Ivory Coast; Gambia; Ghana; Guinea; Guinea-Bissau; Liberia; Mali; Mauritania; Niger; Nigeria; Senegal; Sierra Leone; Togo; Kazakhstan; Kyrgyzstan; Tajikistan; Turkmenistan; Uzbekistan; Mongolia; Afghanistan; Bangladesh; Bhutan; India; Iran; Maldives; Nepal; Pakistan; Sri Lanka; Brunei; Cambodia; Indonesia; Viet Nam; Laos; Malaysia; Myanmar; Thailand; Timor-Leste; Philippines; Armenia; Azerbaijan; Georgia; Iraq; Jordan; Lebanon; Syria; Turkey; Yemen; Albania; Bosnia and Herzegovina; Bulgaria; Croatia; Montenegro; Slovakia; Slovenia; Belize; Costa Rica; El Salvador; Guatemala; Honduras; Mexico; Nicaragua; Panama; Argentina; Bolivia; Brazil; Ecuador; Peru; Uruguay; Venezuela; Haiti; Jamaica


A systematic review (and follow-up review) of studies published or presented between 2002 and 2009 found that ART programs in sub-Saharan Africa retained an average of about 80% of patients after six months, about 70% after two years and about 65% after three years.Three additional systematic reviews have recently examined the evidence for interventions to improve retention in care between HIV diagnosis and ART initiation.

This project will systematically review the scientific literature and assess the efficacy of interventions for promoting retention in care for people with HIV infection in resource-limited settings who have already begun ART. We will define resource-limited settings as those countries identified by the World Bank as being low- or middle-income countries (LMIC)