The majority of patients with pre-diabetes develop overt diabetes and HCV infection is also associated with diabetes. We aimed to evaluate factors associated with pre-diabeticstates among at-risk Latinos with and without HCV infection, including direct measurement of insulin action.  One hundred twenty-three non-cirrhotic, non-diabetic, Latino subjects (52 with HCV infection) were enrolled. All subjects underwent clinical and metabolic evaluation, including oral glucose tolerance testing and measurement of insulin-mediated glucose uptake by steady-state plasma glucose (SSPG) concentration during the insulin suppression test.