Effects of the Chornobyl Accident on Thyroid Cancer and Leukemia & Related Diseases (NO1-CP-21178)

Investigator: Lydia Zablotska, MD, MPA, PhD
Sponsor: Columbia University

Location(s): Ukraine


The 1986 accident at the Chernobyl nuclear power plant remains the most serious nuclear accident in history, and excess thyroid cancers, particularly among those exposed to releases of iodine-131 remain the best-documented sequelae. Failure to take dose-measurement error into account can lead to bias in assessments of dose-response slope. Although risks in the Ukrainian-US thyroid screening study have been previously evaluated, errors in dose assessments have not been addressed hitherto. Dose-response patterns were examined in a thyroid screening prevalence cohort of 13,127 persons aged <18 at the time of the accident who were resident in the most radioactively contaminated regions of Ukraine.