Disease susceptibility and global distribution of genetic variation

Investigator: Mark Seielstad, PhD

Location(s): Philippines; Brazil


Epidemiology and population genetics. The main goal is to identify human genetic variation altering the risk of complex diseases involving immunity (e.g., autoimmunity and susceptibility to infectious diseases) and metabolism (e.g., type 2 diabetes). This puts an emphasis on technologies such as SNP genotyping, and next-generation sequencing to reveal and characterize polymorphisms in genome-scale data. Much of this work is carried out in geographically diverse human populations, which are also the subject of anthropological investigations that seek to characterize the global distribution of genetic variation.