Ceftobiprole vs. Daptomycin and Linezolid for Treatment of Experimental Staph. aureus Endocarditis in Rabbits

Investigator: Henry Chambers, MD
Sponsor: Johnson & Johnson

Location(s): United States


Beta lactam agents are the most active drugs for the treatment of streptococci and methicillin-susceptible Staphylococcus aureus endocarditis. However, methicillin-resistant S. aureus (MRSA) is resistant to all beta lactam agents licensed to date, and alternative treatments are limited. Ceftobiprole was compared to vancomycin, daptomycin, and linezolid in a rabbit model of MRSA aortic valve endocarditis caused by the homogeneously methicillin-resistant laboratory strain COL.