Cap Independent Translation of Dengue Virus
Investigator: Raul Andino-Pavlovsky, PhD
Sponsor: University of California Berkeley
Location(s): United States
An essential step for a productive infection by the dengue flavivirus (DEN) is translation of the m7G-capped, nonpolyadenylated positive-sense RNA genome. Sequences within the DEN 3′ untranslated region (UTR) modulate viral translation, manipulating those sequences can inhance translation.