HIV and Malaria Immunology- For both pathogens, empiric approaches to vaccine design have thus far failed. A better understanding of the correlates of immune control of natural infection are necessary to guide vaccine design. Our approach is to exploit variability in natural susceptibility to infection: to characterize in detail, and to contrast, immune responses that are associated with extremes of control.

The Infant Immune Response -The biological basis for differences in the immune response of infants and adults remains poorly understood. A more complete understanding of these differences and their biological mechanisms may lead to strategies that maximize vaccine efficacy in neonates.