Advanced Technology to Study Visual Function on a Cellular Scale
Location(s): United States
The Bioengineering Research Partnership proposes to develop three state-of-the-art systems that enable the study of vision in living eyes on a cellular level. By deploying and using these systems in three environments - vision testing in animal models, vision testing in healthy normal eyes and vision testing in patients - we outline an effective strategy for answering long-standing questions about foveal vision, and also provide a means for efficient translation of technology into clinical applicability.
Aim 1 : Develop and deploy state-of-the-art AOSLO systems at each site. Demonstrate performance by performing objective densitometry measures in monkeys and humans to map the three classes of cone photoreceptor that subserve color vision.
Aim 2 : Develop improved eye tracking and stimulus delivery capabilities in each system. Confirm performance by using subjective psychophysical tests to map the same three classes of cone photoreceptor as in Aim 1.
Aim 3 : Perform a series of experiments to map the connections and interactions within and between the retina and the brain and to study how we see the world as stable even though our eyes are in constant motion.
Aim 4 : Apply advanced vision testing methods in the clinic to discover mechanisms for cone death in different diseases, to monitor changes in cone function and structure during disease progression and to test the efficacy of treatments that aim to stop or slow disease progression.
Aim 5 : Make eye tracking and targeted stimulus delivery capabilities accessible to a wider audience by providing software, hardware designs and a forum for anyone interesting in building similar advanced systems.