We propose to continue and strengthen the UCSF-Kaiser BIRCWH by recruiting junior faculty Scholars with superb potential to become successful, independent translational or clinical researchers focused on chronic disease in women. We have organized our strengths in women's health into 10 Multidisciplinary Research Teams (breast cancer; cardiovascular disease; complementary and alternative medicine; dementia and cognitive dysfunction; HIV in women; menopause and hormone therapy; obesity; osteoporosis and osteoarthritis; screening for disease and urinary incontinence). Each team is lead by Senior Mentors (an experienced translational and clinical researcher) and includes Resource Faculty from multiple disciplines, Core Methodologists, extensive Research Resources and multiple Repositories of Biological Specimens or Images. Scholars will complete individualized didactic training in basic science or clinical research and practical experience mentored by senior scientists. In consultation with mentors, Scholars will prepare and annually revise a training program including a research agenda similar to NIH K-series proposals. Each plan will be built around milestones toward independence: presentations, publications and independent funding. A biweekly Core Seminar in Women's Health will cover a range of issues in women' health and a biweekly Works-in-Progress session will allow Scholars ample time for expert feedback on research projects.