Dr. Feeney's project will involve detailed longitudinal studies of the HIV-specific immune response and viral evolution during the early years following perinatal infection and will build upon the existing collaboration with Dr. Celia Christie's Perinatal AIDS Program in Kingston, Jamaica. The project compares the HIV-specific immune response during early HIV infection among adults and children, to elucidate developmental differences in the antiviral response of CD4 and CD8 T cells.