NIH National Institute of General Medical Sciences

20 Active Projects

Title Investigator Start End
Mitochondrial Uncoupling and Thermogenesis in Adipose Tissues Kirichok
Hedgehog signaling and signal transduction Kornberg
Gene regulation and function in early embryos Kornberg
Antigen Decoding by T cells Weiner
Mechanism of Gene Silencing Madhani
Physical and Genetic Interaction Landscape of the Tyrosine Kinome Krogan
Molecular Biophysics Training Grant (T32 GM008284) Jacobson
A Pharmacogenomics Study of HIV Latency: The Role of Anti-Programmed Cell Death-1 (PD-1) Signaling Lee
Research Training in Chemistry and Chemical Biology Craik
Design and Experimental Testing of New Docking Methods Shoichet
Maximizing Opportunities for Research Excellence Watkins
Structure and mechanism of the dyein motor Vale
Hepatic degradation of cytochrome P450 enzymes Correia
Structural and Functional Studies of HER Receptor Tyrosine Kinases Jura
Allosteric Regulation in the KDM5 Family of Histone Demethylases Galonic
Testosterone's role in sex-specific outcomes after early anesthesia Sall
Clinical Pharmacology, Drug Action and Pharmacogenetics Burchard
Mapping the conformational cycle of transmembrane transporters Stroud
Regulation by post-translation modifications in response to stress Toczyski
Molecular Basis for Transmembrane Conduction and Signaling Stroud

61 Archived Projects

Title Investigator Start End
Structural Biology and Targeted Drug Design for AIDS Ortiz De Montellano
Selective Destruction of Cytochrome P450 by Drugs Ortiz De Montellano
Biochemistry and Hepatic Toxicity of Carbon Radicals Ortiz De Montellano
Clinical Pharmacology, Drug Action and Pharmacogenetics Benowitz
Mechanism, Specificity, and Inhibition of Cytocchrome P450 Ortiz De Montellano
Global Genetic Interaction Profiling in Prokaryotes Gross
A Specific Mechanism for Non-Specific Inhibition Shoichet
Microtubule Nucleation: Structure & Mechanism Agard
A Web-Based Automatic Virtual Screening System Shoichet
Hypothermia, Anesthesia, and NMR Metabolomics in Ischemic Neonatal Brain Slices Litt
New Frontiers for Small RNA Therapies McManus
TGFBM2 In Development and Disease Akhurst
Genetic Analysis of the Nucleosome and RNA Polymerase II: a Systems Approach Krogan
Mechanisms of gene silencing Madhani
Characterizing Natural Product Permeability and Bioactivity Lexa
Structure, Function and Inhibition of Beta-Lactamases Shoichet
Resource for X-Ray Tomography of Whole Cells Larabell
Clinical Pharmacology, Drug Action and Pharmacogenetics Burchard
Regulating Proteolysis to Dissect Apoptosis Wells
Mutational Analysis of E. Coli Core RNA Polymerase Gross
Membrane Protein Expression Center Stroud
Molecular Mechanisms in Development Kornberg
A Toolkit for Light-Control of Molecular Processes in Living Cells Weiner
Enabling New Translational Discoveries Using a Genomic Data-Driven Nosology Butte
IMP: Software for Hybrid Determination of Macromolecular Assembly Structures Sali
Regulation and Function of a Bacterial Cytoskeleton Mullins
MicroRNA Based Pathway Discovery in Cellular Reprogramming Blelloch
Mechanism of Protein Translocation Across Membranes Walter
Cell Cycle Regulation by Ubiquitin Ligases Toczyski
A Web-Based Automatic Virtual Screening System Shoichet
Integrating computation and genetics to quantify specificity in protein networks Krogan
Exploring Design Principles of Cellular Control Circuits Lim
Medical Scientist Training Program Anderson
Mechanism, Specificity, and Inhibition of Cytochrome P450 Ortiz De Montellano
Center for the Structure of Membrane Proteins Stroud
Function and Pathway Analysis Using Systems-Level Approaches in Prokaryotes Gross
UCSF/UCB Joint Graduate Group in Bioengineering Desai
Modeling Contact Investigation and Rapid Response Porco
Pharmacogenomics of Membrane Transporters Giacomini
Global Analysis of Proteolysis in Apoptosis Wells
Protein Recognition in Signal Transduction Lim
Structural Basis of Protein Homestasis Walter
Microtubule Complexes Involved in Intracellular Transport Vale
Exploration of the Host Genetic Interactions Underlying HIV Infectivity Gordon
Regulation and Targets of the DNA Damage Checkpoint Toczyski
Creating an online resource center for training and professional development in the biomedical sciences Vale
Systematic Phenotypic Analysis of the Gram-positive Envelope Peters
Binding-Site Modeling with Multiple-Instance Machine-Learning Jain
Molecular Basis for Transmembrane Conduction and Signaling Stroud
Role of SOX2 O-GIcNAcylation in pluripotency Panning
Centrosome Structure and the Mechanism of Mt Nucleation by Y-Tubulin Complexes Agard
Research Training in Chemistry and Chemical Biology Craik
A Specific Mechanism for Non-Specific Inhibition Shoichet
Regulation of the Heat Shock Response in E. coli Gross
Signal Integration in Neutrophil Chemotaxis (2 R01 GM084040-06) Weiner
Research Training in Chemistry and Chemical Biology Craik
Pharmaceutical Sciences and Pharmacogenomics Kroetz
BMI Bioinformatics Training Grant Babbitt
Allosteric Inhibition of a Family of Proteolytic Enzymes Craik
Optogenetic dissection of the growth and activation network in T cells O'donoghue
HARC Center: HIV Accessory and Regulatory Complexes Frankel