Immunology

Active Projects: 63

Project Investigator All Topics Start date End date
University of California Global Health Institute Program for Fellows and Scholars Craig Cohen, MD, MPH Sexually Transmitted Infections (STIs), Zoonosis, Emerging Disease, and Drug Resistance, Neglected Tropical Diseases (NTDs), HIV/AIDS, Opportunistic Infection, Tuberculosis, Malaria, Noncommunicable and/or Chronic Disease, Surgery and Anesthesia, Cancer/Oncology, Cardiovascular Disease, Chronic Respiratory Disease, Diabetes, Occupational and Environmental Disease, Diet, Exercise, and Obesity, Malnutrition, Micronutrients, Food Insecurity, Eye Disease and Blindness, Oral Health, Drug and Diagnostics Development, Immunology, Genetics, Pharmacology and Drug Treatment, Neurology and Mental Health, Dementia and Cognitive Impairment, Trauma and PTSD, Women's Health, Aging, Labor and Delivery, Family Planning, Pediatrics, Newborn and Infant Health, Adolescent Health, Health Economics and Policy, Access or Barriers to Care, Immigration and Migration, Stigma and Discrimination, Smoking and Tobacco, International Health Policy, Systematic Reviews and Guideline Development, Epidemiology and Surveillance, Triangulation, Global Strategic Information, Implementation and Behavioral Science, Engagement in Care, Substance Abuse, Treatment Adherence, Health Systems Strengthening, Risk Reduction and Prevention, Residencies, Fellowships, and Postdoctoral Training
Genome Research in African American Scleroderma Patients (GRASP) Consortium Lindsey A. Criswell, MD, MPH Immunology
Defining critical events in early HIV infection-effects of alcohol and early ART J. Michael McCune, MD, PhD HIV/AIDS, Immunology, Substance Abuse
Allosteric Inhibition of a Family of Proteolytic Enzymes Charles S. Craik, PhD Immunology, Pharmacology and Drug Treatment
HARC Center: HIV Accessory and Regulatory Complexes Alan D. Frankel, PhD Zoonosis, Emerging Disease, and Drug Resistance, HIV/AIDS, Immunology
UCSF-GIVI Center for AIDS Research (CFAR) Paul A. Volberding, MD HIV/AIDS, Tuberculosis, Malaria, Cancer/Oncology, Cardiovascular Disease, Drug and Diagnostics Development, Immunology, Pharmacology and Drug Treatment, Neurology and Mental Health, Trauma and PTSD, Women's Health, Pediatrics, Implementation and Behavioral Science, Training and Capacity Building, Training International Scholars and Clinicians
Center for RNA Systems Biology Jonathan S. Weissman, PhD Immunology, Genetics, Pharmacology and Drug Treatment
Optogenetic dissection of the growth and activation network in T cells Immunology
Oxygen Sensors and P450 Monooxygenases in Mycobacertium tuberculosis Paul R. Ortiz De Montellano, PhD Tuberculosis, Immunology
Probing Tumor Metastasis through Chemical Cell Surface Engineering Valerie M. Weaver, PhD Cancer/Oncology, Immunology
Translational development of a novel antibody-drug conjugates against myeloma Bin Liu, PhD Cancer/Oncology, Immunology
Mother-child genetic contributions to autoimmunity Lindsey A. Criswell, MD, MPH Immunology
The gut microbiome: an unexpected contributor to cancer drug resistance Peter J. Turnbaugh, PhD Cancer/Oncology, Immunology, Pharmacology and Drug Treatment
New ways of treating pancreatic cancer based on reversing K-Ras-mediated stemness Frank McCormick, PhD, FRS Cancer/Oncology, Immunology
Cytoskeletal Regulation of T cell Motility and Synaptic Signaling Matthew F. Krummel, PhD Immunology, Epidemiology and Surveillance
Improve the Cho Expression of a ScFv Fragment by Optimizing the DNA Sequence of the ingle chain variable fragment ScFv and/or Leader Sequence James D. Marks, MD, PhD Drug and Diagnostics Development, Immunology
Antigen Decoding by T cells Orion D. Weiner, PhD Immunology
Gilead Sciences Research Scholars Program in Cystic Fibrosis. Oren S. Rosenberg, MD, PhD Immunology
HINT: HIV Immune Networks Team Modeling Core Nevan J. Krogan, PhD, MSc HIV/AIDS, Immunology
BSL3 upgrading for Live-attenuated poliovirus testing Raul Andino-Pavlovsky, PhD Infectious Disease, Immunology
Enhancing Control of HIV by Inhibiting TRAIL Steven G. Deeks, MD HIV/AIDS, Drug and Diagnostics Development, Immunology
UCSF Pediatric Rheumatology Fellowship Erica F. Lawson, MD Immunology, Residencies, Fellowships, and Postdoctoral Training
Physical and Genetic Interaction Landscape of the Tyrosine Kinome Nevan J. Krogan, PhD, MSc Cancer/Oncology, Diabetes, Immunology
A Pharmacogenomics Study of HIV Latency: The Role of Anti-Programmed Cell Death-1 (PD-1) Signaling Sulggi A. Lee, MD HIV/AIDS, Immunology
Randomized, Double-Blind, Placebo-Controlled, Multicenter, Clinical Study Evaluating the Impact of Serum-Derived Bovine Immunoglobulin Protein Isolate, a Medical Food, on Nutritional Status in HIV+ Subjects with HIV-Associated Enteropathy Ma Somsouk, MD, MAS Immunology, Pharmacology and Drug Treatment
Antigen Specificity of Regulatory T cells in Type 1 diabetes T1D Jeffrey A. Bluestone, PhD Diabetes, Immunology
Impact of interferon-alpha inhibition on immune function and viral persistence in HIV disease Steven G. Deeks, MD HIV/AIDS, Immunology
Affinity-Directed Tagging of Protein Binding Partners in Signaling James Wells, PhD Immunology
Impact of Low IL-10 Levels at Birth and Leukemia Risk Joseph Wiemels, PhD Cancer/Oncology, Immunology
Host-Directed Strategies to Create Synergistic Antibacterial Therapies Zoonosis, Emerging Disease, and Drug Resistance, Tuberculosis, Drug and Diagnostics Development, Immunology
Functional Manipulation of Memory Regulatory T cells in Skin Cancer/Oncology, Immunology
Microfluidic immunoprofiling for biomarker discovery in rheumatoid arthritis Adam Abate, PhD Immunology
Trefoil Factor Proteins Modulate Host Immunity against Hookworms Zoonosis, Emerging Disease, and Drug Resistance, Immunology
Microbial Pathogenesis and Host Defense Joanne N. Engel, MD, PhD Immunology, Residencies, Fellowships, and Postdoctoral Training
Racial/Ethnic and Socioeconomic Disparities in Biologic and Clinical Systemic Lupus Erythematosus (SLE) Outcomes Maria Dall'Era, MD Immunology, Access or Barriers to Care, Stigma and Discrimination
Allosteric Regulation in the KDM5 Family of Histone Demethylases Fujimori Danica Galonic, PhD Immunology
Integrative Program in Complex Biological System (ipCBS) Joseph L. Derisi, PhD Drug and Diagnostics Development, Immunology, Genetics, Residencies, Fellowships, and Postdoctoral Training
Structural and Functional Studies of HER Receptor Tyrosine Kinases Natalia Z. Jura, PhD Zoonosis, Emerging Disease, and Drug Resistance, Immunology
Selective AAK1 and GAK inhibitors for combating Dengue and other emerging viral infections Raul Andino-Pavlovsky, PhD Infectious Disease, Zoonosis, Emerging Disease, and Drug Resistance, Immunology
Innate Immune Mechanisms of Primary Graft Dysfunction after Lung Transplantation Mark R. Looney, MD Infectious Disease, Immunology
Timing of ART and homeostasis of the persistent HIV reservoir in the adult J. Michael McCune, MD, PhD HIV/AIDS, Immunology
Impact of Cannabis on Inflammation and Viral Persistence in Treated HIV/SIV Peter W. Hunt, MD HIV/AIDS, Immunology
Regulation of Innate Immune Signaling by Lyn Kinase Clifford A. Lowell, MD, PhD Immunology
Ubiquitin and Psoriasis Averil I. Ma, MD Immunology
Programming Long Term Durable HIV-1 Specific T cell Responses Steven G. Deeks, MD HIV/AIDS, Immunology
The impact of TB co-infection on the reservoir of persistent HIV in vivo J. Michael McCune, MD, PhD HIV/AIDS, Tuberculosis, Immunology
Multicenter Osteoarthritis Study (MOST) Second Renewal Michael C. Nevitt, PhD Immunology, Aging
Using human stem cell-derived thymic epithelium to remodel T1D immune tolerance Mark S. Anderson, MD, PhD Immunology
Immunology & epidemiology of intestinal infectious diseases Robert Owen, MD Zoonosis, Emerging Disease, and Drug Resistance, Immunology, Epidemiology and Surveillance
Biomedical simulation models describing how molecular level events effect changes in phenotype Anthony C. Hunt, PhD Immunology, Genetics
Elucidating mechanisms of tolerance to commensal skin bacteria Immunology
Innate immune regulation of stem cells in bone formation Immunology, Pediatrics
Cytoskeletal Regulation of T cell Motility and Synaptic Signaling Matthew F. Krummel, PhD Immunology
The cell and molecular mechanisms underlying CD28 costimulation Arthur Weiss, MD, PhD Immunology
Observational Study of Pediatric Rheumatic Disease: The CARRA Registry Emily Von Scheven, MD Immunology, Pediatrics
Effector and regulatory T cell responses and protection from clinical malaria Margaret E. Feeney, MD Malaria, Drug and Diagnostics Development, Immunology
Fine-tuning the Neutrophilic Response to Pneumonia Mark R. Looney, MD Immunology
Functional Testing of Host Genes that control HIV Latency in Primary Immune Cells Alexander Marson, MD, PhD HIV/AIDS, Immunology
Inner City Asthma consortium 3 (ICAC3) Susan Lynch, PhD Immunology
A Phase 2, In-Home, Safety and Efficacy Evaluation of Episodic Administration of Open-Label Palovarotene in Subjects with Fibrodysplasia Ossificans Progressiva (FOP) Drug and Diagnostics Development, Immunology
Immune Tolerance Network - OPTIMAL Sandy Feng, MD, PhD Surgery and Anesthesia, Immunology
Plastic States Associated with Cellular Stress and Malignancy: Insights for Prevention and Treatment of Lethal Metaplastic Cancers Thea D. Tlsty, PhD Cancer/Oncology, Immunology
747-303: A Phase 3, Double-Blind, Randomized, Long-Term, Placebo-Controlled, Multicenter Study Evaluating the Safety and Efficacy of beticholic Acid in Subjects with Nonalcoholic Steatohepatitis Mandana Khalili, MD Immunology

Active Projects: 103

Project Investigator All Topics Start date End date
Creating Polyketide Antibiotic Diversity by Engineering Cytochrome P450 Enzymes / UC Discovery Paul R. Ortiz De Montellano, PhD Immunology
Identification of the CD8+Cell Anti-HIV Factor (CAF) Jay A. Levy, MD HIV/AIDS, Immunology
UCSF Comprehensive Center for Immunologic Diseases (CCID) Jeffrey A. Bluestone, PhD Immunology
Use of r-hGh to Enhance Thymopoiesis and to Facilitate Immune Restoration in Individuals Infected with HIV-1 J. Michael McCune, MD, PhD HIV/AIDS, Immunology
Phase II Double Blinded, Placebo-Controlled, Efficacy and Safety Evaluation of Allergen Immunotherapy Co-Administered with Omalizumab, an Anti-IgE mAb Jeffrey A. Bluestone, PhD Immunology
Regulation of Human Thymic Function in Vivo J. Michael McCune, MD, PhD Immunology
NK and T-Cell Costimulation by NKG2D/DAP10 Lewis L. Lanier, PhD Noncommunicable and/or Chronic Disease, Immunology
T Regulatory Cells in HIV Infection Frederick M. Hecht, MD HIV/AIDS, Immunology
T Regulatory Cells and T Cell Activation in HIV Disease Steven G. Deeks, MD HIV/AIDS, Immunology
HIV Controllers: A Potential Model for HIV Eradication Steven G. Deeks, MD HIV/AIDS, Immunology
HIV Vaccine Trials Network - Laboratory Personnel Support Teri Liegler, PhD Immunology
Valganciclovir to Reduce T Cell Activation in HIV Infection Peter W. Hunt, MD HIV/AIDS, Drug and Diagnostics Development, Immunology
Elite Controllers Steven G. Deeks, MD HIV/AIDS, Immunology, Genetics
RAE-1 Family of Proteins in Innate and Adaptive Immunity Lewis L. Lanier, PhD Immunology
CORE B: Intracellular Pathogens and Innate Immunity Joseph L. Derisi, PhD Tuberculosis, Immunology
Examination of the Protective Effect of Pet Ownership on Asthma Development Through Bacterial Community Analysis of Household Dust and Infant Stool Susan Lynch, PhD Occupational and Environmental Disease, Immunology
Project 2: Effect of Humanized Anti Pcrv Antibody on Total Bacterial Community Composition of Adult Patients with Ventilator-Associated Pneumonia Susan Lynch, PhD Immunology
Chemoprophylaxis and HIV-Host Interactions [II] Douglas Nixon, MD, PhD HIV/AIDS, Immunology
Immunogenetic Studies of Autoimmune Disease Lindsey A. Criswell, MD, MPH Immunology
Immunological Targeting of APOBEC Proteins to Cure HIV Infection Douglas Nixon, MD, PhD HIV/AIDS, Immunology
Raltegravir Intensification in Antiretroviral-Treated Patients Exhibiting a Suboptimal CD4+T Cell Response Steven G. Deeks, MD HIV/AIDS, Immunology
NK Cell Receptors and Their Ligands Lewis L. Lanier, PhD Immunology, Genetics
Innate Effector Function and HIV-1 Control Steven G. Deeks, MD HIV/AIDS, Immunology
Testing novel adjuvants to enhance mucosal immunity elicited by inactivated poliovirus vaccine (IPV) Raul Andino-Pavlovsky, PhD Drug and Diagnostics Development, Immunology
Core B: Intracellular Pathogens and Innate Immunity Joseph L. Derisi, PhD Zoonosis, Emerging Disease, and Drug Resistance, Immunology
Inflammatory and Clinical Consequences of Low-Level Viremia in HIV-1 Infected Patients Hiroyu Hatano, MD, MHS HIV/AIDS, Immunology
HIV Entry Inhibitors: A New Therapeutic Option Steven G. Deeks, MD HIV/AIDS, Immunology
UCSF/Ragon Collaboration on HIV "Elite" Controllers Steven G. Deeks, MD HIV/AIDS, Drug and Diagnostics Development, Immunology, Genetics
CNS Immune / Inflammatory Biomarkers in HIV Controllers Richard W. Price, MD HIV/AIDS, Immunology
Siglec-F and Resolution of Allergic Inflammation Homer A. Boushey, MD Immunology, Genetics
Treating HIV-Infected Elite Controllers as a Model of HIV Remission Hiroyu Hatano, MD, MHS HIV/AIDS, Immunology
Preventing and Curing Persistent Infections with Transient FTY/720 Treatment Mary F. Premenko-Lanier, PhD HIV/AIDS, Noncommunicable and/or Chronic Disease, Immunology
Identification of the CD8+ Cell Anti-HIV Factor (CAF) Jay A. Levy, MD HIV/AIDS, Immunology
Characterizing the Role of Immune Activation in HIV Persistence Steven G. Deeks, MD HIV/AIDS, Immunology
13Th International Meeting of the Society for Natural Immunity April 20-24, 2012 Lewis L. Lanier, PhD Immunology, Training and Capacity Building, Training International Scholars and Clinicians
HLA-A Low Resolution Typing Surgery and Anesthesia, Immunology
Initiation of Allergic Immunity by Parasites Richard M. Locksley, MD Immunology
Development of Human mAbs to Target Cardiomyocytes and Cardiac Fibroblasts Cardiovascular Disease, Immunology
B Cells in Central Nervous System (CNS) Autoimmunity Scott Zamvil, MD, PhD Noncommunicable and/or Chronic Disease, Immunology
Childhood Arthritis and Rheumatology Research Alliance Registry (CARRA Registry): Lupus Nephritis Consensus Treatment Plan Maintenance Phase Emily Von Scheven, MD Immunology
Cytokine Signaling in Neurons: Inflammation, Pain and Pruritis Martin Steinhoff, MD, PhD Immunology
DNA methylation profiling in Rheumatoid Arthritis Lindsey A. Criswell, MD, MPH Immunology
Effects of CCR5 - delta-32 Heterozygosity on the HIV-1 Reservoir Steven G. Deeks, MD HIV/AIDS, Immunology, Genetics
Genomics of Lupus: Refining the complex HLA association with SLE across ethnic and phenotype subgroups Lindsey A. Criswell, MD, MPH Immunology
Global Innate Immune Responses to HIV-1 Infection Nevan J. Krogan, PhD, MSc HIV/AIDS, Immunology
Health Professional Research Preceptorship Lindsey A. Criswell, MD, MPH Immunology
Stem Cell differentiation to thymic epithelium for inducing immune tolerance to stem cells Mark S. Anderson, MD, PhD Immunology
Development of Regulatory T-Cells for Treatment of Autoimmune Disease Jeffrey A. Bluestone, PhD Immunology, Pharmacology and Drug Treatment
NKG2D Unresponsive to Responsive Pre-Stimulated State of Resting NK or CD8+ T Cells Lewis L. Lanier, PhD HIV/AIDS, Immunology
Development of Human mABs to CXCR1 and CXCR2 Immunology
Aquaporin-4 (AQP4)-specific T Cells in CNS autoimmunity Scott Zamvil, MD, PhD Immunology
Recent Thymic Emigrants of the CD4 T-Cell Lineage J. Michael McCune, MD, PhD Immunology
Massively Parallel Functioning Testing of Regulatory Elements in Vivo Nadav Ahituv, PhD Immunology, Genetics
A 6 month Multi-center, Open-label Safety Study of VIMOVO in Adolescents Emily Von Scheven, MD Immunology, Adolescent Health
Mechanisms of B Cell Responses in Autoimmune Disease: C12-ALE05-CSF Emily Von Scheven, MD Immunology
Regulation of Genomic Instability in Early Breast Cancer Thea D. Tlsty, PhD Cancer/Oncology, Immunology
Collaborative Network for Clinical Research on Immune Tolerance - Offcampus Portion Jeffrey A. Bluestone, PhD Diabetes, Immunology
Collaborative Network for Clinical Research on Immune Tolerance Jeffrey A. Bluestone, PhD Diabetes, Immunology
Gender-specific Differences Affecting Reactivation of Latent HIV in Treated Patients Steven G. Deeks, MD HIV/AIDS, Immunology, Women's Health
Transition to Independence: Optimizing Outcomes in Childhood-onset Lupus Erica F. Lawson, MD Immunology, Pediatrics
Development of Neuroprotective Molecule for the Treatment of Atophic Age-Related Macular Degeneration Matthew M. Lavail, PhD Eye Disease and Blindness, Immunology
Rheumatology Fellowship Training Award 2014 Erica F. Lawson, MD Immunology, Residencies, Fellowships, and Postdoctoral Training
Discovery of novel, ubiquitin-regulated mechanisms of TB control by macrophages Tuberculosis, Immunology
Ubiquitylation and the Regulation of Immune Homeostasis Averil I. Ma, MD Immunology
A Novel Myeloid Subset Mediating Tolerance to Malaria Mary F. Fontana, PhD Malaria, Immunology
Identifying and targeting HIV persistence in T Cell subsets during ART Steven G. Deeks, MD Drug and Diagnostics Development, Immunology, Genetics
Linking ABIN-1 to SLE Susceptibility Averil I. Ma, MD Immunology, Neurology and Mental Health
Health Professional Research Preceptorship Lindsey A. Criswell, MD, MPH Immunology, Residencies, Fellowships, and Postdoctoral Training
Health Professional Research Preceptorship Lindsey A. Criswell, MD, MPH Immunology, Residencies, Fellowships, and Postdoctoral Training
Understanding the role of treatment timing cells and human genetics to explain why HIV drugs do not cure HIV Frederick M. Hecht, MD HIV/AIDS, Drug and Diagnostics Development, Immunology
Genetic Diversity as a Determinant of Viral Adaptation and Pathogenesis Raul Andino-Pavlovsky, PhD Infectious Disease, Immunology
UCSF Cutaneous Immunology Core: OSM Project Opportunistic Infection, Cancer/Oncology, Immunology
Enabling New Translational Discoveries Using a Genomic Data-Driven Nosology Cancer/Oncology, Immunology
Mechanisms of B Cell Responses in Autoimmune Disease Maria Dall'Era, MD Oral Health, Immunology
The Inflammasome: a Novel Biomarker in ALI/ARDS Michael A. Matthay, MD Immunology
Interferon-independent mechanisms of malaria restriction by helper T cells J. Michael McCune, MD, PhD HIV/AIDS, Malaria, Immunology
Medical and Graduate Student Preceptorship - Mok Lindsey A. Criswell, MD, MPH Immunology, Residencies, Fellowships, and Postdoctoral Training
HIV-Specific T-Cell Responses in Rectal Mucosa Peter W. Hunt, MD Immunology
Immunomodulation of transplant rejection by anti-CD3 mAb Jeffrey A. Bluestone, PhD Immunology
Plasmodium Falciparum Infection and Interference with Effective B Cell Memory Bryan R. Greenhouse, MD Malaria, Immunology, Pediatrics
Human Natural Killer Cell Recognition of Cytomegalovirus Lewis L. Lanier, PhD HIV/AIDS, Immunology
A pilot study of DNA methylation and response to treatment in RA Lindsey A. Criswell, MD, MPH Immunology
Exploring the role of a novel, polymorphic protein family in M. tuberculosis pathogenesis Tuberculosis, Immunology
Trans-Synaptic Signaling during Neuromuscular Development Immunology, Neurology and Mental Health
Treatment of pulmonary fibrosis with inhibitors of integrin alphavbeta1. Dean Sheppard, MD Chronic Respiratory Disease, Drug and Diagnostics Development, Immunology
Pets and the Infant Microbiome: Effect on Immune Maturation and Atopic Asthma Susan Lynch, PhD Occupational and Environmental Disease, Immunology
Trefoil Factors Regulate Th2 Immunity Zoonosis, Emerging Disease, and Drug Resistance, Neglected Tropical Diseases (NTDs), Immunology
Reactivation of latent HIV using recombinant galectin-9 HIV/AIDS, Immunology
Proteomics Analysis of Host-Pathogen Interactions in Histoplasma Anita Sil, MD, PhD Opportunistic Infection, Immunology
Elucidating the Fundamental Biology of Memory Regulatory T cells in Skin Cancer/Oncology, Immunology
Preserving Renal Function and Protective Immunity Via Anti-LFA1-Based CNI Avoidance Peter G. Stock, MD, PhD Immunology
Investigating Mechanisms of HIV Persistence in the Gut Peter W. Hunt, MD HIV/AIDS, Immunology
Treatment of SLE with ajulemic acid,a non-psychoactive cannabinoid derivative Maria Dall'Era, MD Immunology
The ONE Study: A Unified Approach to Evaluating Cellular Immunotherapy in Solid Organ Transplantation Jeffrey A. Bluestone, PhD Immunology
Mechanism regulating ErbB signaling network in head and neck cancer Randall H. Kramer, PhD Cancer/Oncology, Immunology
Polyclonal Tregs to Promote Tolerance in Pediatric Liver Transplant Recipients Sandy Feng, MD, PhD Surgery and Anesthesia, Immunology
A Specific Mechanism for Non-Specific Inhibition Brian K. Shoichet, PhD Immunology
Immunologic determinants of age-related macular degeneration Peter W. Hunt, MD Eye Disease and Blindness, Immunology, Aging
HIV cure with CCR5 negative human IPS hematopoietic stem cells Jay A. Levy, MD HIV/AIDS, Drug and Diagnostics Development, Immunology
Mass Spectrometry Tools in Pursuit of Salivary Biomarkers of Sjogren Syndrome Steven C. Hall, PhD Oral Health, Immunology
HIV-Specific T-Cell Responses in Rectal Mucosa Elizabeth Sinclair, PhD HIV/AIDS, Immunology
Initiation of allergic immunity by parasites Richard M. Locksley, MD Immunology
NP25737 A Phase I Pharmacokinetic and Safety Study of Tocilizumab (TCZ) in Patients Less Than 2 Years Old With Active Systemic Juvenile Idiopathic Arthritis Emily Von Scheven, MD Noncommunicable and/or Chronic Disease, Immunology, Pediatrics