Several sustained-release drug delivery devices have been developed for treating front- and back-of-the-eye diseases. Typically, these systems are designed to achieve sustained theraputic drug concentartions in ocular target tissues that are generally inacessible by concentional means, or as a means of improving patient compliance. The first step in developing a new drug selivery device for the eye involves selecting a non immunigenic material with tunable characteristics. This study assess ocular tolerance and durability of micro and nana-structured thin films.