Identification of Novel Small Molecule Therapeutics for Visceral Leishmaniasis

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Investigator: Adam R. Renslo, PhD
Sponsor: University of Texas Health Science Center

Location(s): United States

Description

New drugs are needed to treat visceral leishmaniasis (VL) because the current therapies are toxic, expensive, and parasite resistance may weaken drug efficacy. We established a novel ex vivo splenic explant culture system from hamsters infected with luciferase-transfected Leishmania donovani to screen chemical compounds for anti-leishmanial activity.