Cardiovascular Disease

Active Projects: 31

Project Investigator All Topics Start date End date
Understanding How Non-Adherence to Hypertension Medication Affects Utilization of GAIA Mobile Health Clinic Services in Mulanje, Malawi Anna Muller, MS Cardiovascular Disease, Treatment Adherence
ENSURE in AF: Prospective, Randomized, Open-Label, Blinded Endpoint (PROBE) Parallel Group Study Comparing Edoxaban with Enoxaparin/Warfarin Followed by Warfarin Alone in Subjects Undergoing Planned electrical cardioversion of nonvalvular atrial fibrillat Cardiovascular Disease
In vivo diagnostics for cardiovascular disease Charles Craik, PhD Cardiovascular Disease
Patient Level Prediction of Clinical Outcomes and Cost-Effectiveness in SPRINT Valy Fontil, MD, MAS, MPH Cardiovascular Disease, Health Economics and Effectiveness, Policy and Standards of Care
Sentreheart project Vincanne Adams, PhD Cardiovascular Disease
Regulation of cardiovascular transcription Cardiovascular Disease, Genetics
HIV Viral Reservoirs and Monocyte Activation in HIV-Associated Atherosclerosis HIV/AIDS, Cardiovascular Disease
Mediators of Atherosclerosis in South Asians Living in America Alka Kanaya, MD Cardiovascular Disease, Immigration and Migration
AIDS Clinical Trials Group: REPRIEVE Trial (A5332 and A5333s) Diane Havlir, MD HIV/AIDS, Cardiovascular Disease
Sustainable approaches to care delivery in Uganda Gabriel Chamie, MD HIV/AIDS, Cancer/Oncology, Cardiovascular Disease, Chronic Respiratory Disease, Diet, Exercise, and Obesity, Implementation and Behavioral Science, Engagement in Care, Treatment Adherence
Epidemiology of stroke Anthony Kim, MD Cardiovascular Disease, Neurology and Mental Health, Dementia and Cognitive Impairment
NCDs in India Reena Gupta, MD Noncommunicable and/or Chronic Disease, Cancer/Oncology, Cardiovascular Disease, Diabetes, Occupational and Environmental Disease, Diet, Exercise, and Obesity, Malnutrition, Micronutrients, Food Insecurity
Enhancing Mexican Capacity for CVD Policy Research Alicia Fernandez, MD Cardiovascular Disease
Optimization of health care expenditures to maximize societal value Dhruv Kazi, MD, MSc, MS Cardiovascular Disease, Drug and Diagnostics Development, Health Economics and Effectiveness
The Impact of Cardiac Care Regionalization on Access, Treatment, and Outcomes Renee Hsia, MD Cardiovascular Disease
Mentoring patient-oriented research on the health consequences of polydrug use Elise Riley, PhD HIV/AIDS, Cardiovascular Disease, Women's Health, Access or Barriers to Care, Stigma and Discrimination, Substance Abuse, Training and Capacity Building
Protein Biomarkers for CVD Prediction in HIV-Infected and Uninfected Veterans HIV/AIDS, Cardiovascular Disease
Mentoring and research in applying digital technologies to prevent chronic Illnesses Yoshimi Fukuoka, RN, PhD Noncommunicable and/or Chronic Disease, Cardiovascular Disease, Diabetes
Training pediatric cardiac surgeons in South East Asia Shunji Sano, MD, PhD Surgery and Anesthesia, Cardiovascular Disease, Training International Scholars and Clinicians
Guideline development for rheumatic heart disease and endocarditis Ann Bolger, MD Cardiovascular Disease, Systematic Reviews and Guideline Development
Mindfulness-education intervention for atrial fibrillation symptom management Linda Ottoboni, RN, MS Cardiovascular Disease, Patient and Peer Education
Japan Trial - Prospective, Multi-Center, Single-Arm Clinical Evaluation of the AVJ-514 System for the Treatment of Symptomatic Chronic Severe Mitral Regurgitation Atif N. Qasim, MD Cardiovascular Disease, Pharmacology and Drug Treatment
International Clinical Research Fellowship Christopher Stewart, MD Zoonosis, Emerging Disease, and Drug Resistance, HIV/AIDS, Tuberculosis, Malaria, Cancer/Oncology, Cardiovascular Disease, Chronic Respiratory Disease, Diabetes, Occupational and Environmental Disease, Eye Disease and Blindness, Oral Health, Residencies, Fellowships, and Postdoctoral Training
Actelion - AC-065A304 Multicenter, open-label, single-group study to assess the tolerability and the safety of the TRANSITion from inhaled tresprostinil to oral selexipag in patients with pulmonary arterial hypertension 20150803 Cardiovascular Disease, Pharmacology and Drug Treatment
MitraClip China Trial CRD956 Atif N. Qasim, MD Cardiovascular Disease, Drug and Diagnostics Development
Pragmatic Trial Comparing Telehealth Care and Clinic-based Care for Uncontrolled High Blood Pressure Noncommunicable and/or Chronic Disease, Cardiovascular Disease
UCSF Career Development Program in Implementation Research in Heart and Lung Diseases Kirsten Bibbins-Domingo, MD, PhD Cardiovascular Disease, UCSF Professional Education
Effect of PCSK9 Inhibition on Cardiovascular Risk in Treated HIV Infection (EPIC-HIV Study) HIV/AIDS, Cardiovascular Disease, Aging
Bring it Down San Francisco: Harnessing cloud-based technology to improve hypertension management in a low-income underserved population Valy Fontil, MD, MAS, MPH Cardiovascular Disease, Engagement in Care, Treatment Adherence
Cardiovascular Inflammation Reduction Trial (CIRT) Cardiovascular Disease
Cognitive Function, Alzheimer's Disease and Related Disorders in the HAALSI Cohort Maria Glymour, ScD, MS Cardiovascular Disease, Dementia and Cognitive Impairment

Active Projects: 113

Project Investigator All Topics Start date End date
Thrombosis Gene Polymorphisms and Early CHD Risk in HERS Eric Vittinghoff, PhD Cardiovascular Disease, Women's Health
California Acute Stroke Prototype Registry (CASPR) / Development of Prototypes for the Paul Coverdell National Acute Stroke Registry Cardiovascular Disease
Warfarin Versus Aspirin in Reduced Cardiac Ejection Fraction (WARCEF) Study Cardiovascular Disease
Estrogen Receptor Variance and CHD Risk in HERS Eric Vittinghoff, PhD Cardiovascular Disease
Resynchronization Hemodynamic Treatment for Heart Failure Management Study (Rythm ICD) Cardiovascular Disease
Failure Time Methods for Family Disease Studies David Glidden, PhD Cardiovascular Disease
Heart Truth Asian & Pacific Islander Community Partnership Initiative Cardiovascular Disease
Molecular Mechanism of Post-myocardial Infarction Cardiac Regeneration by Novel Therapeutic Peptides Cardiovascular Disease
Optimizing Management of Transient Ischemic Attacks Cardiovascular Disease, Pharmacology and Drug Treatment
CASTIA Neurological Core Imaging Lab (NCIL) Cardiovascular Disease, Pharmacology and Drug Treatment, Neurology and Mental Health
Antiplatelet Therapy for Ischemic Stroke and Transient Ischemic Attack in U.S. Community Hospitals Cardiovascular Disease, Pharmacology and Drug Treatment
Closed-Chest Cell Injections into Mouse Mycardium Targeted by Ultrasound Cardiovascular Disease
Quality Improvement in Stroke Prevention (QUISP) Cardiovascular Disease, Neurology and Mental Health
Pharmacokinetics and Pharmacodynamics of Nicotine Neal Benowitz, MD Cardiovascular Disease, Smoking and Tobacco
Impact of Flavanols on Vascular Reactivity and Cardiac Function in Rodents Measured with High Resolution Ultrasound Cardiovascular Disease
Safety of Sports for Patients with Implantable Cardioverter-Defibrillators: A Multicenter Registrry Cardiovascular Disease
Metabolic Syndrome and Atherosclerosis in South Asians Alka Kanaya, MD Cardiovascular Disease, Diabetes
Pivotal Clinical Study of the CardioFocus Endoscopic Ablation System (CF-EAS) for the Treatment of Symptomatic Atrial Fibrillation (ENABLE-AF) Cardiovascular Disease
Pacemarker & Beta-Blocker Therapy Post-Myocardial Infarct Cardiovascular Disease
NSA Guidelines Cardiovascular Disease, Systematic Reviews and Guideline Development
Doris Duke Charitable Foundation International Clinical Research Fellowship Program Joel Palefsky, MD HIV/AIDS, Tuberculosis, Malaria, Cancer/Oncology, Cardiovascular Disease, Oral Health, Neurology and Mental Health, Women's Health, Pediatrics, Newborn and Infant Health, Immigration and Migration, Training and Capacity Building, Residencies, Fellowships, and Postdoctoral Training
Replace Registry Cardiovascular Disease
Body Surfacing Mapping to Guide Resynchronization Therapy for Congestive Heart Failure Cardiovascular Disease
Endothelial Function and Glucose Tolerance in South Asians Alka Kanaya, MD Cardiovascular Disease, Diet, Exercise, and Obesity
UCSF-Kaiser Building Interdisciplinary Research Careers in Women's Health Program Ruth Greenblatt, MD HIV/AIDS, Noncommunicable and/or Chronic Disease, Cancer/Oncology, Cardiovascular Disease, Diet, Exercise, and Obesity, Dementia and Cognitive Impairment, Women's Health, UCSF Professional Education
MAPS: Matrix And Platinum Science, A Prospective, Randomized, Multicenter, Trial Investigating Matrix2 tm and GDC? Coils for the treatment of intracranial saccular aneurysms Trial Cardiovascular Disease, Pharmacology and Drug Treatment
Bone Marrow Cell Therapy for Cardiac Disease: Impact of Donor Age and Infarction Cardiovascular Disease
Adapting of the Coronary Heart Disease Policy Model to U.S. Subpopulations Kirsten Bibbins-Domingo, MD, PhD Cardiovascular Disease
Therapeutic Effects of Pharmacological Manipulation of Intracellular Nitric Oxide Levels in Cardiovascular Disease Cardiovascular Disease, Pharmacology and Drug Treatment
NAAccord (CHK-UP on HIV Supplement) Jeffrey Martin, MD, MPH HIV/AIDS, Noncommunicable and/or Chronic Disease, Cancer/Oncology, Cardiovascular Disease
Neuroform Angiographic Analysis (Subset of MAPS study data) Cardiovascular Disease, Drug and Diagnostics Development
Developmental Regulation of Semilunar Valve and Ventricular Septum Formation Cardiovascular Disease
Development of Human mAbs to Target Cardiomyocytes and Cardiac Fibroblasts Cardiovascular Disease, Immunology
A Randomized Trial of Unruptured Brain Arteriovenous Malformation (ARUBA) Cardiovascular Disease
Perceived Discrimination, Stress Responses and Cardiovascular Regeneration among African Americans Cardiovascular Disease, Stigma and Discrimination
Angiogenesis in Moving Cardiac Tissue: Influence of Motion on Endothelial Pattern Formation and Gene Expression Cardiovascular Disease
Microrna Regulation of Cardiac Cell Polarity in Development and Disease Cardiovascular Disease
Stimulants and Childhood Stroke: a Population-Based Nested Case-Control Study Nancy Hills, PhD Cardiovascular Disease, Pediatrics
Outcomes Modeling for VA Return on Investment Analysis Kirsten Bibbins-Domingo, MD, PhD Noncommunicable and/or Chronic Disease, Cardiovascular Disease, Diet, Exercise, and Obesity, Health Economics and Effectiveness
Enhancing Mexican Capacity for Cardiovascular Policy Research Kirsten Bibbins-Domingo, MD, PhD Noncommunicable and/or Chronic Disease, Cardiovascular Disease, Health Economics and Effectiveness
Restorative Yoga for Therapy of the Metabolic Syndrome (RHYTHMS) Study Alka Kanaya, MD Cardiovascular Disease, Diabetes, Diet, Exercise, and Obesity
Cardiac Regeneration Through Growth Factor Eluting Microrod Scaffolds Tejal Desai, PhD Cardiovascular Disease
Evaluation of Harmful Effects of Cannabis Smoke on Vascular Endothelial Function Cardiovascular Disease, Occupational and Environmental Disease, Smoking and Tobacco
Protein Inhibitor of Galectin-3 to Limit Fibrosis after Myocardial Infarction Cardiovascular Disease
Epi4K: Gene discovery in 4,000 Epilepsy Genomes (4/7) Elliott Sherr, MD, PhD Cardiovascular Disease, Genetics
Teleconsultation by Emergency Medical Services For Acute Stroke Recognition: Feasibility Study Cardiovascular Disease
The cardiovascular impact of household air pollution in semi-urban and rural communities in Puno, Peru Cardiovascular Disease, Occupational and Environmental Disease
Myocardial Reconstruction for the Treatment of Congestive Heart Failure (CHF) Cardiovascular Disease
Myocardial Reconstruction for the Treatment of CHF Cardiovascular Disease
A Self-Care Intervention for Hispanic Patients with Heart Failure Cardiovascular Disease
Impact of Regionalization of Care in Acute Stroke Patients Cardiovascular Disease
Inflammation, Viral Replication, and Atherosclerosis in Treated HIV Infection HIV/AIDS, Cardiovascular Disease, Pharmacology and Drug Treatment
Administration of an ACE Inhibitor to Improve Endothelial Function in Treated, HIV-infected Individuals HIV/AIDS, Cardiovascular Disease
Transcriptional Control of Endothelial Cell Specification and Sub-specification Cardiovascular Disease
St. Jude EP Fellowship Program Cardiovascular Disease
Ethnic/Racial Variations of Intracerebral Hemorrhage (ERICH) Cardiovascular Disease, Neurology and Mental Health
Insulin Resistance Intervention after Stroke (IRIS) Trial Cardiovascular Disease, Diabetes
Effect of IL-1B inhibition on inflammation and cardiovascular risk in HIV HIV/AIDS, Cardiovascular Disease
Regulation of cardiovascular transcription Cardiovascular Disease, Newborn and Infant Health
Phase III Clinical Trial "Platelet Oriented Inhibition in New Tia" - Drug: Plavix Cardiovascular Disease, Pharmacology and Drug Treatment
An observational study assessing the management of gastrointestinal and urogenital bleeding events in patients with atrial fibrillation treated with dabigatran etexilate (PRADAXA) Cardiovascular Disease
Association of Occupational Noise Exposure with Cardiovascular Diseases among Career Firefighters Cardiovascular Disease, Occupational and Environmental Disease
SOCRATES - Acute Stroke Or Transient Ischaemic Attack Treated with Aspirin or Ticagrelor and Patient Outcomes Cardiovascular Disease, Pharmacology and Drug Treatment
Hypertension Treatment Adherence in a Low-Income Tribal Region of Rural Southern India. A Qualitative Study Kaylan Agnew, MS Cardiovascular Disease
VIPS: Vascular Effects of Infection in Pediatric Stroke Heather Fullerton, MD Cardiovascular Disease, Neurology and Mental Health, Pediatrics
Acute Cardiopulmonary Effects of Controlled Exposure to Wood Smoke Cardiovascular Disease, Chronic Respiratory Disease, Occupational and Environmental Disease
The Impact of Cardiac Care Regionalization on Access, Treatment, and Outcomes Renee Hsia, MD Cardiovascular Disease, Access or Barriers to Care
Effect of low dose methotrexate on endothelial function and inflammation in HIV HIV/AIDS, Cardiovascular Disease
Enhancing Mexican Capacity for Cardiovascular Disease (CVD) Policy Research Kirsten Bibbins-Domingo, MD, PhD Cardiovascular Disease, Training and Capacity Building
Addressing Disparities in Chronic Disease with a Teen and Young Adult Focus Kirsten Bibbins-Domingo, MD, PhD Cardiovascular Disease, Diabetes
Effects of Psychosocial Stress on Endothelial Progenitor Cells Cardiovascular Disease
Evaluating Perceptions of Cardiovascular Disease Risk and Prevention: A Qualitative Study in an UnderResourced Setting in Rural South India Joan Chang, MS Cardiovascular Disease
A Randomized, Double Blind Placebo-controlled Phase 2a Study to Assess the Effect of CCR2 Antagonism by MLN1202 on Atherosclerotic Inflammation in Subjects with Stable Atherosc Yerem Yeghiazarians, MD Cardiovascular Disease
University of California Global Health Institute Program for Fellows and Scholars Craig Cohen, MD, MPH Sexually Transmitted Infections (STIs), Zoonosis, Emerging Disease, and Drug Resistance, Neglected Tropical Diseases (NTDs), HIV/AIDS, Opportunistic Infection, Tuberculosis, Malaria, Noncommunicable and/or Chronic Disease, Surgery and Anesthesia, Cancer/Oncology, Cardiovascular Disease, Chronic Respiratory Disease, Diabetes, Occupational and Environmental Disease, Diet, Exercise, and Obesity, Malnutrition, Micronutrients, Food Insecurity, Eye Disease and Blindness, Oral Health, Drug and Diagnostics Development, Immunology, Genetics, Pharmacology and Drug Treatment, Neurology and Mental Health, Dementia and Cognitive Impairment, Trauma and PTSD, Women's Health, Aging, Labor and Delivery, Family Planning, Pediatrics, Newborn and Infant Health, Adolescent Health, Health Economics and Effectiveness, Access or Barriers to Care, Immigration and Migration, Stigma and Discrimination, Smoking and Tobacco, Policy and Standards of Care, Systematic Reviews and Guideline Development, Epidemiology and Surveillance, Triangulation, Global Strategic Information, Implementation and Behavioral Science, Engagement in Care, Substance Abuse, Treatment Adherence, Health Systems Strengthening, Risk Reduction and Prevention, Residencies, Fellowships, and Postdoctoral Training
Molecular and Cellular Basis of Cardiovascular Disease Cardiovascular Disease
UCSF-GIVI Center for AIDS Research (CFAR) Paul Volberding, MD HIV/AIDS, Tuberculosis, Malaria, Cancer/Oncology, Cardiovascular Disease, Drug and Diagnostics Development, Immunology, Pharmacology and Drug Treatment, Neurology and Mental Health, Trauma and PTSD, Women's Health, Pediatrics, Implementation and Behavioral Science, Training and Capacity Building, Training International Scholars and Clinicians
SEARCH (Sustained East Africa Research in Community Health) Study in Kenya and Uganda/ Gates Diane Havlir, MD HIV/AIDS, Tuberculosis, Malaria, Cardiovascular Disease, Diabetes
The Selective Marketing of Sugar-Sweetened Beverages (SSBs) to Children: An Analysis of Internal Industry Documents Laura Schmidt, PhD Cardiovascular Disease, Diabetes, Occupational and Environmental Disease, Diet, Exercise, and Obesity, Pediatrics
Predicting Stroke after Trauma (PSAT) Heather Fullerton, MD Cardiovascular Disease
Overcoming impairment of bone marrow cell therapy for myocardial infarction: Role of B cells Cardiovascular Disease
Endothelial Primary Cilia Protect Against Atherosclerosis Jeremy Reiter, MD, PhD Cardiovascular Disease
Genetic and molecular pathophysiology of ATS Louis Ptacek, MD Cardiovascular Disease, Genetics
ZERO AF Clinical Evaluation of the Blazer Open-Irrigated Ablation Catheter for the Treatment of Paroxysmal Atrial Fibrillation Cardiovascular Disease
AIDS Clinical Trials Group: REPRIEVE Trial Ancillary Study Diane Havlir, MD HIV/AIDS, Cardiovascular Disease
Prospective, Comparative, Randomized, Multi-Center, Double-Blinded, Placebo- Controlled, Phase 2a Study of the Safety and Efficacy of CMX-2043 for Periprocedural Injury Protection in Subjects Undergoing Coronary Angiography at Risk of Rad Yerem Yeghiazarians, MD Cardiovascular Disease
The distribution and determinants of Non-communicable Diseases in informal settlements (slums) in Northeastern Brazil Alon Unger, MD Noncommunicable and/or Chronic Disease, Cardiovascular Disease, Occupational and Environmental Disease
Impact of a novel multicomponent nutrition intervention on cardiovascular disease risk factors among food-insecure adults with HIV in the Dominican Republic Kartika Palar, PhD Cardiovascular Disease, Malnutrition, Micronutrients, Food Insecurity
Preventing Morbidity and Mortality and Heart Failure Among Persons with Chronic Renal Insufficiency Michael Shlipak, MD Noncommunicable and/or Chronic Disease, Cardiovascular Disease
Childhood SES Factors: Impact on age-related cognitive and vascular health Maria Glymour, ScD, MS Cardiovascular Disease
Ectopic fat and atherosclerosis in South Asians Alka Kanaya, MD Cardiovascular Disease
Ectopic Fat and Atherosclerosis in South Asians Alka Kanaya, MD Noncommunicable and/or Chronic Disease, Cardiovascular Disease
Effect of Pitavastatin on Kidney Function in HIV-infected Persons Diane Havlir, MD HIV/AIDS, Cardiovascular Disease
Role of Monocyte Oxidative Stress and Mineralocorticoid Receptor Signaling on Cardiovascular Disease and Persistent Inflammation in Antiretroviral-Treated HIV+ Persons HIV/AIDS, Cardiovascular Disease
Discrimination and biomarkers of cardiometabolic risk Thu Nguyen, ScD, MSPH Cardiovascular Disease
Prime: Signaling and Transcriptional Networks in Cardiac Patterning; Project 3 (UCSF, Black, BL): Regulation of cardiac gene expression by MEF2-Myocardin transcriptional complexes Cardiovascular Disease
Cardiovascular, Pulmonary & Hematological Disease in HIV: Prevention & Treatment Peter Hunt, MD HIV/AIDS, Cardiovascular Disease, Chronic Respiratory Disease, Aging
Impact of Health Literacy Interventions on Outcome of Patients with Diabetes and Hypertension in Latin America and the Caribbean: A Systematic Review Lucia Abascal, MD, MS Noncommunicable and/or Chronic Disease, Cardiovascular Disease, Diabetes
Implementation of Interventions to Improve the Uptake of Cardiovascular Disease Prevention Strategies in Sub-Saharan Africa: A Systematic Review and Meta-analysis Rah-Sha Al-Hassan, MS Noncommunicable and/or Chronic Disease, Cardiovascular Disease
DIADS Project 2: Racial Disparities in Ischemic Stroke and Atherosclerotic Risk Factors in the Young Heather Fullerton, MD Cardiovascular Disease, Neurology and Mental Health
Medtronic - 2015 EP Fellowship 20141212 RB Cardiovascular Disease, Residencies, Fellowships, and Postdoctoral Training
Advancing Sugary Beverage Reforms Through the Private Sector (Toolkit) Laura Schmidt, PhD Cardiovascular Disease, Diet, Exercise, and Obesity, Health Systems Strengthening
Social and Cultural Influences on cardiovascular risk factors in South Asians Alka Kanaya, MD Cardiovascular Disease
St Jude Medical - 2015 Electrophysiology Fellowship 20150226 Cardiovascular Disease, Residencies, Fellowships, and Postdoctoral Training
Predictors of Cardiomyopathy Progression in a Cohort of Bolivian Patients with Chagas Disease Caryn Bern, MD, MPH Zoonosis, Emerging Disease, and Drug Resistance, Neglected Tropical Diseases (NTDs), Cardiovascular Disease
Addressing Disparities in Chronic Disease with a Teen and Young Adult Focus Kirsten Bibbins-Domingo, MD, PhD Noncommunicable and/or Chronic Disease, Cardiovascular Disease, Diabetes, Diet, Exercise, and Obesity
Barber-Pharmacist Coordination to Improve Bldd Pressure Management in Black Men Kirsten Bibbins-Domingo, MD, PhD Cardiovascular Disease
Lifecourse Cardiovascular Risk, Depression and Cognition in Black & White Adults Eric Vittinghoff, PhD Cardiovascular Disease
Effect of low dose methotrexate on endothelial function and inflammation in HIV HIV/AIDS, Cardiovascular Disease
Measuring Relative Cardiovascular Health Risks of Inhaled Tobacco Products Cardiovascular Disease, Smoking and Tobacco
Randomized, Double-Blind Placebo-Controlled Phase 2a Study to Assess the Effect of CCR2 Antagonism by MLN1202 on Atherosclerotic Inflammation in Subjects with Stable Atherosclerotic Cardiovascular Disease Using FDG PET/CT Imaging Cardiovascular Disease
Controlled Thirdhand Smoke Exposure Core Cardiovascular Disease, Chronic Respiratory Disease, Occupational and Environmental Disease
Cardiovascular, Pulmonary & Hematological Disease in HIV: Prevention & Treatment Peter Hunt, MD HIV/AIDS, Cancer/Oncology, Cardiovascular Disease, Aging
Image-Based Numerical Predictions of Hemodynamics following Vascular Intervention David Saloner, PhD Cardiovascular Disease, Drug and Diagnostics Development, Neurology and Mental Health