NIH National Institute of Allergy and Infectious Disease

56 Active Projects

Title Investigator
Start End
Defining the unique properties of the distinct signaling machinery used by the TCR
Single-cell trancriptomic analysis of HIV infected CD4 cells in blood and lymphoid tissue using PCR activated cell sorting Abate
EV71 intra-host evolution, attenuation and vaccine development Andino-Pavlovsky
Insect adaptive immunity Andino-Pavlovsky
Biology of Infectious Diseases Training Program Chambers
UZ-UCSF Clinical Trials Unit Chirenje
Identification of diagnostic and prognostic host biomarkers of Zika virus infection by transcriptome profiling Chiu
The impact of antimalarials and insecticide resistance on malaria transmission in Uganda Conrad
Delaney AIDS Research Enterprise to Cure HIV Deeks
Therapeutic vaccination and PD-1 blockade in treated HIV disease Deeks
Program for Resistance, Immunology, Surveillance & Modeling of Malaria in Uganda (PRISM) Renewal Dorsey
Adapting to a changing environment: How surface contact induces virulence factor production in Pseudomonas aeruginosa Engel
Cellular and Bacterial Dynamics in Tuberculosis Ernst
Antigen export in M. tuberculosis evasion of CD4 T cells Ernst
Effector and regulatory T cell responses and protection from clinical malaria Feeney
Hair Extensions;: Using Hair Levels to Interpret Adherence, Effectiveness and Pharmacokinetics with Real-World Oral PrEP, the Vaginal Ring, and Injectables Gandhi
Point-of-care Urine Monitoring of Adherence (PUMA): Testing a Real-Time Urine Assay of Tenofovir in PrEP Gandhi
Mentoring Multidisciplinary Patient-Oriented Research in Engagement in HIV Care Geng
Statistical methods for clinical trials of novel PrEP agents Glidden
Mentoring translational scientists in international infectious disease research Greenhouse
Novel serologic assays of P. falciparum exposure for improved surveillance in control and elimination Greenhouse
Training in HIV Translational Research Havlir
Simplified Isoniazid Preventive Therapy (SPIRIT) Strategy to Reduce TB Burden Havlir
Targeting latent HIV-1 Reservoirs with the Antibody-Drug Conjugate, Brentuximab Vedotin Henrich
Single Cell Characterization of Latent HIV-1 Reservoirs Henrich
Impact of Chemotherapy and Stem Cell Transplant on HIV-1 Reservoir Dynamics Henrich
Microfluidic PCR Method to Identify and Characterize HIV-Infected Single Cells Henrich
HIV Viral Reservoirs and Monocyte Activation in HIV-Associated Atherosclerosis Hsue
Determinants of Functional Immune Defects in Treated HIV Infection and Aging Hunt
Improving the molecular diagnosis of drug resistant tuberculosis Kato-Maeda
HPMI: Host Pathogen Mapping Initiative Krogan
Host genetic predictors of plasma IL-1b levels and pharmacogenomics of in vivo IL-1b blockade during treated HIV disease Lee
Regulation of Innate Immune Signaling by Lyn Kinase Lowell
Evaluation of doxycycline post-exposure prophylaxis to reduce sexually transmitted infections in PrEP users and HIV-infected men who have sex with men Luetkemeyer
Childhood Tuberculosis Infection Among School-Age Children in Rural Uganda Marquez
Timing of ART and homeostasis of the persistent HIV reservoir in the adult McCune
The impact of TB co-infection on the reservoir of persistent HIV in vivo McCune
Novel methods of pharmacologic monitoring for multidrug resistant tuberculosis treatment in the setting of HIV infection Metcalfe
Sputum Transcriptomic Expression Profiling in Study 31: Express 31 Nahid
TB Surrogate Markers for Assessing Response to Treatment (TB SMART Study) Nahid
The Immunologic Impact of In Utero Malaria Exposure and Prenatal Chemoprevention Prahl
Chemical Methods for Ferrous Iron Dependent Drug Delivery Renslo
Discovery of Novel Antimalarial Leads Targeting Translational Repression in Plasmodium parasites Renslo
Protein secretion in bacterial pathogens Rosenberg
Resistance of Malaria Parasites to Artemisinin-Based Therapies Rosenthal
Pharmacodynamics of Antimalarial Chemoprevention Rosenthal
Novel Therapeutics for Treatment of River Blindness and Lymphatic Filariasis Sakanari
Identifying Optimal Treatment Strategies for Tuberculosis Treatment Savic
Gene circuits that control morphology in Histoplasma Sil
Elucidating the mechanism of macrophage death during infection with the AIDS-associated opportunistic pathogen Histoplasma capsulatum Sil
Using Genetics and Genomics to Dissect Coccidioides Spherulation Sil
Placental malaria: The role of inflammation at the maternal-fetal interface Valderramos
Recent Advances in AIDS and HIV Research Volberding
UCSF-Gladstone Center for AIDS Research Volberding
Mentoring in Patient Oriented Research on Food Insecurity, HIV and Aging, Weiser K24 Weiser
Redefining Tuberculosis Meningitis with Metagenomics and Host Transciptomics Wilson

240 Archived Projects

Title Investigator
Start End
Role of Innate Immunity in Controlling HIV Infection
Immunologic and Virologic Features of Early HIV Infection
Regulatory circuits and virulence in candida albicans
Dissecting the HLA contribution to Rheumatoid Arthritis
HIV cure with CCR5 (-) human IPS hematopoietic stem cells
Dissecting the HLA Contribution to Rheumatoid Arthritis
Tissue-Based Small Animal Model for HIV Drug Discovery
Role of Innate Immunity in Controlling HIV Infection
Role of Innate Immunity in Controlling HIV Infection
Regulatory Circuits That Link Cell Fate and Virulence in Histoplasma Capsulatum
UCSF AIDS Research Training Program
Heat Shock Protein 90 and HIV Persistence
Role of Innate Immunity in Controlling HIV Infection
Resequencing Microarray for Rapid Detection and Antimicrobial Resistance Profiling
HIV cure with CCR5 negative human IPS hematopoietic stem cells
Thymic Medullary Epithelial Cell Turnover and Control of Immune Tolerance
RNA Protein Interactions in Poliovirus Replication Andino-Pavlovsky
RNAi as an Intercellular Antiviral Defense Mechanism Andino-Pavlovsky
Recombinant Picornaviruses as AIDS Vaccines Andino-Pavlovsky
Genetic Diversity as a Determinant of Viral Adaptation and Pathogenesis Andino-Pavlovsky
Mechanism of enterovirus replication Andino-Pavlovsky
2013 NIH Workshop on Protein Homeostasis and Viral Infection Andino-Pavlovsky
Replication, Pathogenesis and Evolution of RNA Viruses, Including Dengue Andino-Pavlovsky
Protein homeostasis mechanisms underlying enterovirus replication and evolution Andino-Pavlovsky
Genetic Diversity as a Determinant of Viral Pathogenesis and Attenuation Andino-Pavlovsky
Mechansims of poliovirus replication Andino-Pavlovsky
Immunomodulation of transplant rejection by anti-CD3 mAb Bluestone
Spontaneous Autoimmune Model of Peripheral Neuropathy Bluestone
Spontaneous Autoimmune Model of Peripheral Neuropathy Bluestone
Role of Innate Lymphoid Cells in Autoimmunity Bluestone
Spontaneous Autoimmune Model of Peripheral Neuropathy Bluestone
Immunomodulation of Transplant Rejection by Anti-CD3 mAb Bluestone
Immunomodulation of Transplant Rejection by Anti-CD3 mAb Bluestone
Role of Notch 1 in Immunie Tolerance Bluestone
Collaborative Network for Clinical Research on Immune Tolerance Bluestone
Collaborative Network for Clinical Research on Immune Tolerance - Offcampus Portion Bluestone
Microarray-Based Detection and Typing of Rhinoviruses Boushey
Rhinoviruses, Epithelial Cells, and Airway Function Boushey
Exploring Statins As a Small Molecule Therapy for Treatment of Schistosomiasis Caffrey
An Automated High Throughput Phenotypic Screen for Schistosomiasis Drug Discovery Caffrey
TB Guideline Observation and Adherence in Low Income Countries (TB GOAL) Cattamanchi
A Clinical Trial for Uncomplicated Skin Infections in Areas of Epidemic Community-Associated Methicillin-Resistant Staphylococcus aureus (MRSA) Chambers
Biology of Infectious Diseases Training Program [III] Chambers
Novel Mechanisms of Beta-lactam Resistance in Staph Aureus, Continuation A120553 Chambers
Biology of Infectious Diseases Training Program [II] Chambers
Biology of Infectious Diseases Training Program Chambers
Novel Mechanisms of Beta-lactam Resistance in Staph Aureus Chambers
Penicillin Interactive Proteins of Staphylococcus Aureus Chambers
Biology of Infectious Diseases Training Program [I] Chambers
Novel Mechanisms of Beta-Lactam Resistance in Staph Aureus Chambers
Novel Mechanisms of Beta-Lactam Resistance in Staph aureus Chambers
Molecular Epidemiology and Geospatial Analysis of Tuberculosis Transmission in Uganda Chamie
The Zimbabwe-San Francisco HIV Prevention Trials Unit Chipato
The Bixby Center for Global Reproductive Health - Annual Research Day Conference Chirenje
UZ-UCSF Clinical Trials Unit Chirenje
University of Zimbabwe-UCSF Clinical Trials Unit Chirenje
Real-Time Unbiased Pathogen Detection in Febrile Illnesses by Nanopore Sequencing Chiu
Virus Detection Using Microarrays and Characterization of a Novel Cardiovirus Chiu
A Rapid Pan-Viral Microarray Diagnostic for Category A-C Biodefense Pathogens Chiu
Preclinical Development of MucoCept Cohen
Reproductive Infectious Disease (RID) Fellowship Cohen
Host-Directed Strategies to Create Synergistic Antibacterial Therapies Cox
Discovery of novel, ubiquitin-regulated mechanisms of TB control by macrophages Cox
Secretion of Virulence Factors by Mycobacterium tuberculosis Cox
Regulation of ESX-1 Secretion and Its Role in Mycobacterium tuberculosis Virulence Cox
Manipulation of Macrophage Responses by M. tuberculosis Cox
Regulation of ESX-1 secretion and its role in M. tuberculosis virulence Cox
Role of MmpL Transporters in M. Tuberculosis Virulence Cox
Targeting Allosteric Sites to Modulate Protein Interactions and Function Craik
A Novel Proteomic Approach to Tuberculosis Biomarker Discovery using Human Exosomes Davis
Oral Wash for Nucleic Acid Diagnosis and Prognosis of TB in HIV-Infected Ugandans Davis
Mobile Health for Implementation of Home-based TB Contact Investigation in Uganda Davis
Oral Wash for Nucleic Acid Diagnosis and Prognosis of TB in HIV-Infected Ugandans Davis
Oral Wash for Nucleic Acid Diagnosis and Prognosis of TB in HIV-infected Ugandans Davis
Preventing the Establishment of Enfuvirtide-Resistance in the Latent Reservoir Deeks
Treatment Intensification for Drug-Resistant HIV Deeks
T Regulatory Cells and T Cell Activation in HIV Disease Deeks
The Impact of Early Antiretroviral Therapy on HIV Persistence and Inflammation Deeks
The Impact of Early Antiretroviral Therapy on HIV Persistence and Inflammation Deeks
DARE: Delaney AIDS Research Enterprise to Find a Cure Deeks
Impact of HIV-Associated Inflammation on Disease Deeks
Population Genetics of the PO1 Locus of SIV and HIV-1 Delwart
Novel Anti-Malarials by Combinatorial Pharmacogenomics Derisi
Program for Resistance, Immunology, Surveillance, and Modeling of Malaria in Uganda (PRISM) Dorsey
Program for Resistance, Immunology, Surveillance & Modeling of Malaria in Uganda Dorsey
New approaches to study Pseudomonas-host interactions Engel
Novel approaches to identify host genes required for Chlamydia pathogenesis Engel
Microbial Pathogenesis and Host Defense Engel
Microbial Pathogenesis and Host Defense Engel
High throughput proteomics to dissect Chlamydia-host cell interactions Engel
Sputum M. tuberculosis DNA Kinetics during TB Treatment in Patients with HIV Everett
Utility of Contact Investigation of Drug Susceptible and Resistant Tuberculosis in Tanzania Fair
The Impact of CD8 T Cells on Viral Control and Evolution in HIV-Infected Infants Feeney
Mentoring Translational Researchers for Careers in Pediatric Global Health Feeney
Effector and Regulatory T Cell Responses and Protection from Clinical Malaria Feeney
Molecular Mechanisms of Plasmodium falciparum Adherence to the Human Placenta Fisher
Plugging Hair ARV Levels as Adherence Biomarkers into HIV Prevention Trials Gandhi
Plugging Hair ARV Levels as Adherence Biomarkers into HIV Prevention Trials Gandhi
Hair measures to assess adherence and explain outcomes in an HIV clinical trial Gandhi
Assessing Antiretroviral Exposure in Diverse Populations Gandhi
Early Mortality in HIV-Infected Patients Starting Antiretroviral Therapy in Africa Geng
Sexually Transmitted Infections Clinical Trials Group (STICTG) Giudice
Comparison of Pharmacologic Markers of Exposure to HIV Pre-Exposure Prophylaxis Glidden
Chemoprophylaxis for HIV Prevention: Analysis of Bone and Metabolic Effects Glidden
The Connie Wofsy Women's HIV Study Greenblatt
The Connie Wofsy Women's HIV Study Greenblatt
The Hair Trigger Study Greenblatt
The Connie Wofsy Women's HIV Study Greenblatt
Innovative Methods for Measuring Antiretroviral Exposure Greenblatt
The Connie Wofsy Women's HIV Study Greenblatt
WIHS Treatment Exposure and Viral Rebound Study / AIDS Research Greenblatt
The Connie Wofsy Womens' HIV Study Greenblatt
Plasmodium Falciparum Infection and Interference with Effective B Cell Memory Greenhouse
Translational Studies of Plasmodium Falciparum Infection Dynamics Greenhouse
Regulatory T Cell Influence on Infant and Adult Immune Responses to HIV Hartigan-O'Connor
Virologic and Host Factors Contributing to HIV Control in Elite Controllers Hatano
Adult AIDS Clinical Trials Unit (AACTU) Havlir
Clinical Studies of Interactions Between HIV and Malaria Havlir
Therapeutic Strategies for HIV Disease Havlir
Training in HIV Translational Research Havlir
Therapeutic Strategies for HIV Disease Havlir
UCSF HIV Clinical Trials Unit Havlir
Training in HIV Translational Research Havlir
Reducing Failure-to-Initiate ART: Streamlined ART Start Havlir
Reducing Failure-to-Initiate ART: Streamlined ART Start Strategy (START) Havlir
A Novel Microfluidic HIV-1 Co-Culture Assay to Quantify Latent Reservoirs Henrich
Trefoil Factors Regulate Th2 Immunity Herbert
Population-Based Molecular Epidemiology of Tuberculosis in San Francisco Hopewell
Population-Based Molecular Epidemiology of Tuberculosis Hopewell
Tuberculosis Epidemiology and Novel Transmission Routes in Rural Tanzania Hopewell
Effect of Drug Resistance on Transmissibility and Pathogenicity of M. Tuberculosis Hopewell
Utility of Rapid Diagnostic Tests for Malaria Hopkins
Evaluating Re-active Surveillance Strategies for Malaria Elimination in Swaziland Hsiang
IDO-induced Tryptophan Catabolism and Mortality in Treated HIV-infected Africans Hunt
Innate Immune Response Genetics and T cell Activation in Treated HIV Infection Hunt
The Determinants of T Cell Activation in HIV Infection Hunt
Inflammation, T Cell Senescence, and Mortality in Treated HIV Infection Hunt
Cervical Maturity, Mucosal Immunity, and Chlamydia trachomatis Infections Hwang
Immunologic Consequences of Highly Effective Antimalarial Chemoprevention Jagannathan
Global Health Comparative Effectiveness: A Data Synthesis Method Applied to HIV Kahn
Immunological Detection and Control of Experimental Uncomplicated Malaria Kim
Immunological Detection and Control of Experimental Uncomplicated Malaria Kim
Mechanisms of Bartonella Virulence in AIDS Patients Koehler
Bartonella: dissecting niche-specific adaptation in a human pathogen Koehler
Mechanisms of Bartonella Virulence in AIDS Patients Koehler
Bartonella: dissecting niche-specific adaptation in a human pathogen Koehler
Health Empowerment for MSM in South Africa Lane
Predicting Resistance: Validating Mathematical Models Lietman
An Intervention for Male STD Patients in India / HIV Related Lindan
Initiation of allergic immunity by parasites Locksley
CD4+ T Cell Receptors in Leishmaniasis Locksley
Parasite Immunity Orchestrated by Th2 Cells Locksley
Initiation of Allergic Immunity by Parasites Locksley
Initiation of allergic immunity by parasites Locksley
Mechanisms of Leukocyte Integrin Signaling Lowell
Signaling by Cytoplasmic Tyrosine Kinases in Leukocytes Lowell
Mechanisms of Neutrophil Activation Lowell
Mechanisms of Neutrophil Activation Lowell
Development of Botulinum Neurotoxin Immunotherapy, Serotypes C, D, F, and G Marks
Generation of Therapeutic Antibodies for Serotype F Botulism Marks
Trispecific Monoclonal Antibody for Botulinum Neurotoxin Intoxication Therapy Marks
Generation of therapeutic antibodies for serotype F botulism (Continuation of A120963 from NIH G Pool to Subaccount) Marks
Childhood Tuberculosis Infection Among School-Age Children in Rural Uganda Marquez
HIV Effects on the Central Hematolymphoid System McCune
Interruption of Maternal-Fetal Transmission of HIV McCune
Layering of the Human Immune System, Viral Infections, and Childhood Asthma McCune
Assessing Laboratory Correlates of Immune Protection McCune
Anti-Gag Antibodies and Enhancement of Lentiviral Disease Progression McCune
HIV Effects on the Central Hematolymphoid System McCune
Thymic Function in Adults With HIV-1 Disease McCune
Human Immune System Layering and the Neonatal Response to Vaccines McCune
The Impact of Tolerance in the Newborn on Lentiviral Infection McCune
Novel flow cytometry-based assay for HIV-infected cells McCune
Interferon-independent mechanisms of malaria restriction by helper T cells McCune
Bay Area Hepatitis C Cooperative Research Center McCune
Lead Identification to Clinical Candidate Selection: Drugs for Chagas' Disease McKerrow
Targeting Cysteine Proteases--Antiparasitic Chemotherapy McKerrow
Host Protein Degradation by Schistosome Parasites McKerrow
Improving Early Identification of Drug Resistant Tuberculosis in HIV Prevalent Settings Metcalfe
UZ-UCSF Collaborative Research Program Miller
TB Surrogate Markers for Assessing Response to Treatment (TB SMART Study) Nahid
Protective Immunity in HIV Highly Exposed but Uninfected Subjects Nixon
Innate NKT Cells in HIV Infection Nixon
Innate Natural Killer T (NKT) Cells in HIV Infection Nixon
T Regulatory Cells in HIV Infection Nixon
Human Endogenous Retroelements in HIV Immunopathogenesis Nixon
An Endogenous Retroelement Vaccine against HIV-1 Nixon
Protective immunity in HIV Highly Exposed but Uninfected Subjects Nixon
Innate NKT Cells in HIV Infection Nixon
A Novel APOBEC-Based Vaccine Approach for HIV Nixon
Viral Tropism and Immune Control in HIV Nixon
Cell Mediated Immunity in HIV-Infected Children Nixon
Interaction between Innate and Th2 Lymphocytes in Helminth Immunity Nussbaum
Oxygen Sensors and P450 Monooxgenases in Mycobacterium tuberculosis Ortiz De Montellano
Oxygen Sensors and P450 Monooxygenases in Mycobacertium tuberculosis Ortiz De Montellano
San Francisco STDs CRC Padian
STD Risks and Latino Adolescents' Sexual Networks Padian
Coming Together to Overcome HIV/AIDS in Zimbabwe and Zambia Padian
Phase 1/2 Trial of Pharmacological HIV-1 Prevention Page
Host Polymorphisms and Uncomplicated Malaria Parikh
Fetal Zika virus infection: role of the human placenta Pereira
Fetal HCMV Infection: Role of the Human Placenta Pereira
Fetal HCMV Infection: Role of the Human Placenta Pereira
HIV Status and Reproductive Aging Affect Liver Fibrosis in HIV/HCV Infected Women Peters
Structure-Aided Design of CYP51 Inhibitors for Treatment of Parasitic Infections Podust
Chemical Methods for Ferrous Iron Dependent Drug Delivery Renslo
Chemical Methods for Ferrous Iron Dependent Drug Delivery Renslo
Chemical Methods for Ferrous Iron Targeted Drug Delivery Renslo
HPV Epidemiology and Response to Screening (HEARTS) Riley
Structural and functional studies of M. tuberculosis type VII secretion Rosenberg
Discovery of Oxaboroles as New Antimalarial Agents Rosenthal
Resistance of Malaria Parasites to Artemisinin-Based Combination Therapies Rosenthal
Clinical and Molecular Studies of Drug Resistant Malaria [I] Rosenthal
Resistance of Malaria Parasites to Artemisinin-Based Combination Therapies Rosenthal
Discovery of Oxaboroles as New Antimalarial Agents Rosenthal
Falcipain Cysteine Proteases of Malaria Parasites Rosenthal
Evaluation of Falcipain as an Antimalarial Drug Target Rosenthal
Discovery of Oxaboroles as New Antimalarial Agents Rosenthal
Host-pathogen Interactions during Vertical Transmission of Listeria monocytogenes Ross
Quantitative mapping of interactions between dengue virus and its hosts Shah
A Chemical Map of T Cell Signaling Shokat
Proteomics Analysis of Host-Pathogen Interactions in Histoplasma Sil
Gene Circuits that Control Morphology in Histoplasma Sil
Molecular Dissection of Histoplasma-Induced Host-Cell Death Sil
Drug Resistant Malaria Clinical and Laboratory Studies Staedke
HIV, HCV, and gender effects on Liver, Bone, and Vascular Health Tien
HIV, HCV, and gender effects on Liver, Bone, and Vascular Health Tien
UCSF-Gladstone Center for AIDS Research (CFAR) Volberding
Recent Advances in AIDS and HIV Research Volberding
Recent Advances in AIDS and HIV Research Volberding
UCSF-GIVI Center for AIDS Research . Volberding
UCSF-GIVI Center for AIDS Research (CFAR) Volberding
Regulation of the Development of Trypanosoma brucei Wang
Regulation of the Development of Trypanosoma brucei Wang
Translation Regulation in Giardia lamblia Wang
Double-Stranded RNA Virus in Giardia Wang
Purine Metabolism in Trichomonas Vaginalis Wang
Regulation of the Development of Tryanosoma brucei Wang
Evaluation of Novel Tuberculosis Screening Strategies for People living with HIV Yoon
Point-of-care C-reactive protein-based tuberculosis screening among people living with HIV: planning a comparative effectiveness trial Yoon