Traumatic Brain Injury and The Aging Brain: Predictors of Clinical Trajectories

Sponsor: American Federation for Aging Research

Location(s): United States


A lifetime History of Traumatic Brain Injury (TBI) is extremely common and is an important risk factor for aging- related Neurodegenerative Diseases. It is unknown, however, why some patients with TBI remain resilient as they age while others experience devastating decline in cognition, motor, mood, and behavioral function. The proposed work will address this critical knowledge gap by studying Predictors of cognitive, motor, mood/behavior, and global function after acute and remote TBI in older adults.

TBI affects nearly 2 million American each year with The highest incidence in late life. While TBI is increasingly recognized as an important risk factor for a variety of Neurodegenerative Diseases, most notably dementia and Parkinson's disease, The etiology and pattern of cognitive, behavioral, motor, and functional Trajectories of older adults after acute or remote TBI as well as Clinical Predictorsof these Trajectories are largely unknown. This knowledge gap has stunted research on diagnosis, treatment, and prevention of post-TBI Neurodegenerative Diseases ofAging. The proposed research seeks to address this critical knowledge gap via The following 2 specific aims: (1) to define detailed Clinical Trajectories and Predictors ofTrajectories after acute TBI in older adults, (2) to define detailed Clinical trajectries and Predictors of Trajectories after remote TBI in older adults. This innovative work will lead to significant advances in The understanding of specific cognitive, behavioral, motor, and functional outcomes after acute and remote TBI in older adults, will identify potentially modifiable Clinical Predictors of these outcomes, and may generate new hypotheses regarding treatment strategies or biological underpinnings of these outcomes. Thus, The results from this research will directly guide Clinical assessment, prognostication, and risk-stratification of older adults wth acute or remote TBI and will advance research to treat or prevent post-TBI neurodegeneration.