Spinal Structure and Function after 90 Days Long-Duration Simulated Space Flight and Recovery

Investigator: Jeffrey C. Lotz, PhD
Sponsor: University of California San Diego (UCSD)

Location(s): United States


Test the hypotheses that

(1) simulated microgravity leads to supraphysiologic disc swelling and increased disc height that may stiffen the lumbar motion segment and cause abnormal segmental movement patterns,

(2) deconditioning of paraspinal muscles contributes to decrements in vertebral and intervertebral disc variables, and

(3) different mechanisms regulate the observed skull-calvaria bone growth during actual spaceflight as compared to simulated microgravity.