Recurrence of CIN2+ among HIV-infected women in Kisumu, Kenya two years after treatment with LEEP

Investigator: Keerthana Anand, MS
Sponsor: Global Health Sciences Education

Location(s): United States


Cervical cancer is an AIDS defining illness, demonstrating a higher incidence and more aggressive course in HIV positive women. Highly active anti-retroviral therapy (HAART) has not proven to be effective in preventing the progression of cervical lesions into invasive disease and in turn may increase the risk of developing invasive disease due to the prolonged lifespan achieved with HAART use. HIV-infected women are also more likely to have recurrence of cervical pre-cancerous lesions after treatment with loop electrosurgical excision procedure (LEEP). Kisumu Kenya has an HIV prevalence rate of 23% among women, placing them at an increased risk for cervical cancer. Therefore, knowledge about the rate and risk factors associated with an increased recurrence of cervical cancer could help formulate guidelines for prevention programs and reduce the burden of invasive cervical disease among HIV infected women in Kisumu, Kenya.

Mentor: Megan J. Huchko, MD, MPH