PBO Study: Impact of LLINs with and without PBO in Uganda: a cluster-randomised trial - Innovative Vector Control Consortium (IVCC)

Investigator: Grant Dorsey, MD
Sponsor: Liverpool School of Tropical Medicine

Location(s): Uganda


Long-lasting insecticidal nets (LLINs) are a key malaria control intervention, but their effectiveness is threatened by resistance to pyrethroid insecticides. Some new LLINs combine pyrethroids with piperonyl butoxide (PBO), a synergist that can overcome P450-based metabolic resistance to pyrethroids in mosquitoes. In 2017-2018, the Ugandan Ministry of Health distributed LLINs with and without PBO through a national mass-distribution campaign, providing a unique opportunity to rigorously evaluate PBO LLINs across different epidemiological settings.