PBO Study: Impact of LLINs with and without PBO in Uganda: a cluster-randomised trial - Innovative Vector Control Consortium (IVCC)
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Investigator: Grant Dorsey, MD
Sponsor: Liverpool School of Tropical Medicine
Location(s): Uganda
Description
Long-lasting insecticidal nets (LLINs) are a key malaria control intervention, but their effectiveness is threatened by resistance to pyrethroid insecticides. Some new LLINs combine pyrethroids with piperonyl butoxide (PBO), a synergist that can overcome P450-based metabolic resistance to pyrethroids in mosquitoes. In 2017-2018, the Ugandan Ministry of Health distributed LLINs with and without PBO through a national mass-distribution campaign, providing a unique opportunity to rigorously evaluate PBO LLINs across different epidemiological settings.