We are studying the mechanisms of immune response to hepatitis C therapy through the Bay Area Hepatitis C Cooperative Study. Through community and participatory research, we are also evaluating hepatitis B management and liver cancer screening practices in hepatitis B-infected underserved populations including the impact of liver cancer screening on mortality. Our focus on health services research involves evaluation of the impact of educational interventions on patient and provider knowledge, attitudes, and barriers to hepatitis C and hepatitis B care as well as primary care-specialist care coordination and access to care for viral hepatitis.