Patient Oriented Research in Kidney Disease

Investigator: Chi-Yuan Hsu, MD, MS
Sponsor: NIH National Institute of Diabetes and Digestive and Kidney Diseases

Location(s): United States


Acute deteriorations in kidney function are commonly encountered in clinical practice. But much remains unknown about the distribution of this disease entity on a population basis, its role in the transition from chronic to end-stage renal disease and the extent to which is it is associated with actual underlying kidney injury. The studies proposed by Dr. Hsu in this application will help advance knowledge and serve as a platform for rigorous training of young clinician-researchers committed to a career in kidney disease Patient-Oriented Research.

The underlying theme is to advance understanding of the significance and nature of acute deteriorations in kidney function on several fronts. The specific aims are: Aim 1: To determine the population incidence of acute renal failure (ARF)/acute kidney injury (AKI) overall and in clinically important subgroups and to determine potential driving forces behind this. Aim 2: To determine the importance of abrupt loss of renal function as a pathway leading directly from chronic kidney disease (CKD) to end-stage renal disease (ESRD). Aim 3: To determine the extent to which acute kidney function deterioration in the setting of acute heart failure is associated with elevated levels of markers of renal tubular injury.