Misoprotsol versus Placebo with Laminaria for Cervical Ripening before Late Second Trimester Abortion

Investigator: Philip Darney, MD, MS

Location(s): United States


A placebo-controlled, randomized trial used to determine the effectiveness of buccal misoprostol as an adjunct to cervical ripening before late second-trimester abortion by dilation and evacuation (D&E) by comparing to placebo. Misoprostol's effectiveness relative to placebo will be assessed in terms of procedure duration, cervical dilation, blood loss, morbidity, complications and patient acceptability in women undergoing pregnancy termination between 21-23 1/7 weeks gestation.