Mechanisms of Pulmonary Ischemia-Reperfusion Injury

Sponsor: NIH National Heart, Lung, and Blood Institute

Location(s): United States


Coronary heart disease is the leading global cause of death in the developed world, with myocardial infarction (MI) being associated with significant morbidity and mortality. Myocardial injury following MI can be either lethal or sub-lethal, depending on the duration and severity of ischaemia endured. The success of timely primary percutaneous coronary intervention (PCI) in those presenting with an acute MI has seen mortality rates fall to 6% [3], as the length of ischaemia is directly related to the final extent of infarction. ischaemia-reperfusion injury (IRI), with resultant apoptosis, necrosis and post-ischaemic dysfunction remains a key determinant of the final extent of infarction, degree of myocardial salvage and the overall associated morbidity and mortality of MI