International Case-Control Study of Malignant Glioma

Investigator: Margaret R. Wrensch, PhD
Sponsor: Baylor College of Medicine

Location(s): United States


Gliomas are a rare and understudied disease that is rapidly fatal. The proposed Case-Control Study of primary malignant Glioma (Gliogene Consortium) includes 13-centers, and will address the role of genetic susceptibility in sporadic cases. It will identify common genetic variants contributing to the risk of Glioma from a genome wide association Study.

Glioma comprises about 40% of all primary brain tumors accounting for as many as 26,000 U.S. and European deaths annually. Inherited Susceptibility plays a role with 2-fold increased risk of Glioma among first-degree relatives of Glioma cases.  "Genetic Epidemiology of Glioma International Consortium"  address the role of Inherited