Genetic Risk Factors for Pneumonia in SLE

Investigator: Lindsey A. Criswell, MD, MPH
Sponsor: Arthritis Foundation

Location(s): United States


Pneumonia causes substantial morbidity and mortality in systemic lupus erythematosus (SLE) and represents the most common lung disease in this population. The contribution of genetic risk factors to susceptibility to pneumonia in patients with SLE has not been thoroughly investigated. Recently, investigators have identified genetic polymorphisms associated with an increased risk of infection in healthy hosts and patients with autoimmune disease. Some of these same polymorphisms have also been associated with SLE itself and with specific disease manifestations, such as nephritis .