Genetic Analysis of the TNF Pathway in Psoriasis

Investigator: Wilson J. Liao, MD
Sponsor: NIH National Institute Arthritis and Musculoskeletal and Skin Diseases

Location(s): United States


This proposal describes a 5 year training program for the development of an academic career in the field of psoriasis genetics. Research will focus on the role of TNF pathway gene variants in psoriasis. Recent results from a large genome wide association study in psoriasis demonstrate that two genes in the TNF pathway, TNFAIP3 and TNIP1, are major risk factors for the development of psoriasis. The research project will perform fine mapping of these two genes to identify causal variants, and additionally examine other genes in this pathway for genetic association. High throughput genotyping, DNA sequencing, and copy number assays will be employed. The aggregate data will provide the first detailed picture of TNF pathway genes in psoriasis. The proposed training program draws on the combined resources of the UCSF Institute for Human Genetics, UCSF Department of Dermatology, and UCSF Psoriasis Center. Psoriasis is a common autoimmune condition affecting more than 7.5 million Americans. The psychological and economic burden of this disease on patients is enormous. The proposed research aims to help identify the cause of psoriasis and enhance the development of new treatments for this disease.