DoD-ADNI -Effects of TBI and PTSD on AD in Veterans using Imaging and Biomarkers in ADNI

Investigator: Howard J. Rosen, MD
Sponsor: University of California San Diego (UCSD)

Location(s): United States


Veterans with traumatic brain injury (TBI) and post-traumatic stress disorder (PTSD) appear to have a greater associated risk of Alzheimer’s disease and dementia. The purpose of DOD ADNI is to examine the possible connections between TBI and PTSD, and the signs and symptoms of Alzheimer’s disease on Veterans as they age. The results of the DOD ADNI study will lead to greater efforts to develop treatment and prevention studies to help reduce these long-term affects of TBI and PTSD injuries.

Funded by the Department of Defense (DOD), this study is a first step towards a larger, more comprehensive study of dementia risk factors in Veterans.


  • Optimize, standardize and validate imaging/biomarkers for AD clinical trials
  • Determine biomarkers with high sensitivity to detect change
  • Determine biomarkers which predict future change: identify AD pathology
  • Improve clinical AD trials
  • Provide data to all investigators
  • Create a world wide network for clinical trials