Airway Microbiome in Severe Asthma

Investigator: Homer Boushey, MD
Sponsor: Genentech, Inc.

Location(s): United States


The purpose of this research study is to find out if the microbiome in the lungs is different in healthy people without asthma compared to people with asthma. This study will also find out if the microbiome of the lungs changes when people with asthma take a daily "controller" medication called an inhaled corticosteroid.

Two broad specific aims of this study are: 1) to evaluate whether the microbiota of the bronchial airways in atopic asthmatics and atopic healthy controls differ in microbial diversity, richness, evenness, or composition of specific bacterial taxa and 2) to determine whether inhaled corticosteroid treatment alters bronchial microbial community composition in asthmatics.