Age-Dependent Immune Responses to Hepatitis B: a Mouse Model of Human Disease

Investigator: Jody L. Baron, MD, PhD
Sponsor: NIH National Institute of Allergy and Infectious Disease

Location(s): United States


Hepatitis B virus (HBV) is a small, partially double-stranded DNA virus that causes acute and chronic hepatitis. An estimated 400 million people are chronically infected worldwide, 125 million are people chronically infected in the United States, many suffering early death due to liver failure and primary liver cancer (HCC). There are at least one million deaths annually from HBV-related disease. This makes HBV one of the world¿s most common and serious human pathogens. Our proposed research will shed light on HBV disease pathogenesis and help identify new potential therapeutic targets to prevent the devastating consequences of chronic HBV infection.