ACTG: AIDS Clinical Trials Group; MASTER SUBCONTRACT -- U01AI068636
Investigator: Francesca Aweeka, PharmD
Sponsor: Social & Scientific Systems, Inc.
Location(s): Malawi; Zambia; Botswana; South Africa; India; Thailand; United States
The International Maternal Pediatric Adolescent AIDS Clinical Trials Network (IMPAACT) is a cooperative group of institutions, investigators, and other collaborators organized for the purpose of evaluating potential therapies for HIV infection and its sequelae in the infant, pediatric, adolescent and pregnant women populations.
IMPAACT has two components; one is funded by the National Institute for Allergy and Infectious Diseases (NIAID), and one by the National Institute of Child Health and Human Development (NICHD).
Pediatric HIV infection has been successfully transformed from a universally fatal infection of childhood to a manageable chronic disease requiring a lifetime of efficacious, tolerable and safe ART. The Primary Therapy Scientific Committee’s (PTSC) agenda aims to optimize antiretroviral management of children from infancy through adolescence and into young adulthood. A major emphasis of the PTSC work is to determine the efficacy, safety, tolerance, pharmacokinetics (PK) and drug: drug interactions of existing and novel ARV agents and formulations alone and in combination across the pediatric age and developmental spectrum.
Increasingly, pharmacokinetic studies of new formulations and new drugs are enrolling participants from IMPAACT sites in Africa, Asia, North and South America. Therapeutic and strategy trials are now designed to provide findings that will inform treatment practices and guidelines throughout the world.